A study on semaphorin-regulated diverse cellular events
| Project/Area Number |
25291044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
Takagi Shin 名古屋大学, 理学(系)研究科(研究院), 准教授 (90171420)
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| Co-Investigator(Renkei-kenkyūsha) |
IHARA Kunio 名古屋大学, 遺伝子実験施設, 准教授 (90223297)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | セマフォリン / 表皮 / エンドサイトシス / シナプトタグミン / 線虫 / 器官形成 / 細胞形態制御 / 膜小胞 / 線虫C. elegans |
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| Outline of Final Research Achievements |
In this study we have studied regulation of vesicle transport by the semaphorin signal in the nematode C. elegans. Through genetic as well as cell-biological analyses, we have demonstrated that semaphorin negatively regulates endocytosis in ray epidermal cells. We also revealed that the synaptotagmin1/Stonin2 system, a well-known regulator of synaptic vesicle recycling in neurons, plays a critical role in vesicle transport in ray epidermal cells. Our study shows importance of participation of the semaphorin-regulated vesicle transport in regulation of the cell shape.
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Report
(5 results)
Research Products
(10 results)
