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A study on semaphorin-regulated diverse cellular events

Research Project

Project/Area Number 25291044
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Cell biology
Research InstitutionNagoya University

Principal Investigator

Takagi Shin  名古屋大学, 理学(系)研究科(研究院), 准教授 (90171420)

Co-Investigator(Renkei-kenkyūsha) IHARA Kunio  名古屋大学, 遺伝子実験施設, 准教授 (90223297)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywordsセマフォリン / 表皮 / エンドサイトシス / シナプトタグミン / 線虫 / 器官形成 / 細胞形態制御 / 膜小胞 / 線虫C. elegans
Outline of Final Research Achievements

In this study we have studied regulation of vesicle transport by the semaphorin signal in the nematode C. elegans. Through genetic as well as cell-biological analyses, we have demonstrated that semaphorin negatively regulates endocytosis in ray epidermal cells. We also revealed that the synaptotagmin1/Stonin2 system, a well-known regulator of synaptic vesicle recycling in neurons, plays a critical role in vesicle transport in ray epidermal cells. Our study shows importance of participation of the semaphorin-regulated vesicle transport in regulation of the cell shape.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (10 results)

All 2017 2014 2013 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Astrocytic IP3Rs: Contribution to Ca2+ signalling and hippocampal LTP.2017

    • Author(s)
      Sherwood MW, Arizono M, Hisatsune C, Bannai H, Ebisui E, Sherwood JL, Panatier A, Oliet SH, Mikoshiba K.
    • Journal Title

      Glia

      Volume: 65 Issue: 1 Pages: 502-513

    • DOI

      10.1016/j.bbrc.2016.09.034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterizing Semaphorin Signaling in vivo using C. elegans2017

    • Author(s)
      Nukazuka A, Takagi S
    • Journal Title

      Methods in Molecular Biology

      Volume: 1493 Pages: 485-498

    • DOI

      10.1007/978-1-4939-6448-2_34

    • ISBN
      9781493964468, 9781493964482
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optical silencing of C. elegans cells with light-driven proton pumps2014

    • Author(s)
      Ayako Okazaki, Megumi Takahashi, Naoya Toyoda, Shin Takagi
    • Journal Title

      Methods

      Volume: 68 Issue: 3 Pages: 425-430

    • DOI

      10.1016/j.ymeth.2014.02.030

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulsed Irradiation Improves Target Selectivity of Infrared Laser-Evoked Gene Operator for Single-Cell Gene Induction in the Nematode C. elegans2014

    • Author(s)
      Suzuki M, Toyoda N, Takagi S
    • Journal Title

      PLoS ONE

      Volume: 9(1) Issue: 1 Pages: e85783-e85783

    • DOI

      10.1371/journal.pone.0085783

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IR Laser-induced gene expression in targeted single cells of C. elegans. Development2013

    • Author(s)
      Suzuki M,Toyoda N, Shimojyou M, Takagi S
    • Journal Title

      Growth and Differentiation

      Volume: 55(4) Issue: 4 Pages: 454-61

    • DOI

      10.1111/dgd.12061

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese studies on neural circuits and behavior of Caenorhabditis elegans.2013

    • Author(s)
      Sasakura, H., Tsukada, Y., Takagi, S. & Mori, I.
    • Journal Title

      Front. Neural Circuits

      Volume: 7 Pages: 187-187

    • DOI

      10.3389/fncir.2013.00187

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Analysis of morphological changes of epidermal cells producing sensory rays in the C. elegans male tail2014

    • Author(s)
      Shin Takagi, Hiroki Tanaka, Ayana Kobayashi
    • Organizer
      C. elegans Development, Cell Biology and Gene Expression Meeting.
    • Place of Presentation
      奈良市  (新公会堂)
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of morphological changes of epidermal cells producing C. elegans sensory rays2014

    • Author(s)
      Shin Takagi, Hiroki Tanaka, Ayana Kobayashi
    • Organizer
      日本発生生物学会
    • Place of Presentation
      名古屋市 (ウィンク名古屋)
    • Year and Date
      2014-05-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Efficient EGL-17/FGF secretion by epidermal cells in C. elegans requires components of the synaptic vesicle recycling machinery

    • Author(s)
      田中 洋樹,下条 真生、高木 新
    • Organizer
      日本発生生物学会大46回大会
    • Place of Presentation
      松江 Kunibiki-messe
    • Related Report
      2013 Annual Research Report
  • [Remarks] Development and Neurobiology of C. elegans

    • URL

      http://www.bio.nagoya-u.ac.jp/~zootwo/170313%20HP.htm

    • Related Report
      2016 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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