Studies on developmental stage specific gene expression regulation and metacyclogenesis in African trypanosomes
Project/Area Number |
25292167
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Veterinary medical science
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Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
Principal Investigator |
Inoue Noboru 帯広畜産大学, 原虫病研究センター, 教授 (10271751)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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Keywords | アフリカトリパノソーマ / ライフサイクル / 細胞分化 / 遺伝子 / 転写翻訳制御 / ツェツェバエ |
Outline of Final Research Achievements |
In this research project, we have investigated in detail mechanisms of stage-specific gene expression regulation in African trypanosomes, which cause animal trypanosomoses, such as animal African trypanosomoses, Surra and Dourine. As a result, we have found that gene expression of congolense epimastigote specific protein (cesp) was regulated by cis-elements located in the 3UTR. In addition we found a novel epimastigote stage-specific hemoglobin receptor (TcEpHbR), which could be a novel target gene for development of trypanocidal drugs and vaccines against animal trypanosomoses.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Characterization of an epimastigote-stage-specific hemoglobin receptor of Trypanosoma congolense2016
Author(s)
Yamasaki, S., Suganuma, K., Yamagishi, J., Asada, M., Yokoyama, N., Kawazu, S., Inoue, N.
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Journal Title
Parasites & Vectors
Volume: in press
Issue: 1
Pages: 299-299
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Studies of trypanosomiasis in the Luangwa valley, north-eastern Zambia2015
Author(s)
Laohasinnarong D, Goto Y, Asada M, Nakao R, Hayashida K, Kajino K, Kawazu S, Sugimoto C, Inoue N, Namangala B
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Journal Title
Parasit Vectors
Volume: 8
Issue: 1
Pages: 497-497
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Application of crude and recombinant ELISAs and immunochromatographic test for serodiagnosis of animal trypanosomosis in the Umkhanyakude district of KwaZulu-Natal province, South Africa2015
Author(s)
Nguyen, T. T., Motsiri, M. S., Taioe, M. O., Mtshali, M. S., Goto, Y., Kawazu, S., Thekisoe, O. M. M., Inoue, N.
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Journal Title
Journal of Veterinary Medical Science
Volume: 77
Issue: 2
Pages: 217-220
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A TeGM6-4r antigen-based immunochromatographic test (ICT) for animal trypanosomosis2015
Author(s)
Nguyen, T. T., Ruttayaporn, N., Goto, Y., Kawazu, S., Sakurai, T., Inoue, N.
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Journal Title
Parasitology Research
Volume: 114
Issue: 11
Pages: 4319-4325
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Identification and Characterization of a <i>Trypanosoma congolense</i> 46 kDa Protein as a Candidate Serodiagnostic Antigen2014
Author(s)
Zhou, M., Suganuma, K., Ruttayaporn, N., Nguyen, T.T., Yamasaki, S., Igarashi, I., Kawazu, S., Suzuki, Y., Inoue, N.
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Journal Title
Journal of Veterinary Medical Science
Volume: 76
Issue: 6
Pages: 799-806
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Adenosine-uridine-rich element is one of the required cis-elements for epimastigote form stage-specific gene expression of the congolense epimastigote specific protein2013
Author(s)
Suganuma, K., Mochabo, K. M., Hakimi, H., Yamasaki, S., Yamagishi, J., Asada, M., Kawazu, S. and Inoue, N.
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Journal Title
Molecular and Biochemical Parasitology
Volume: 191
Issue: 1
Pages: 36-43
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression, immunolocalization and serodiagnostic value of Tc38630 protein from Trypanosoma congolense2013
Author(s)
Mochabo, K. M., Zhou, M., Suganuma, K., Kawazu, S., Suzuki, Y. and Inoue, N.
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Journal Title
Parasitology Research
Volume: 112
Issue: 9
Pages: 3357-3363
DOI
Related Report
Peer Reviewed
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