| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
|---|
| Outline of Final Research Achievements |
Vector-borne pathogens such as malaria parasite or filaria transit between biologically different hosts of mammals and arthropods. Host path conversion is an important event for pathogens and is essential for adapting to the parasitic environment and establishing transmission. Therefore, in this study, we aimed to clarify the host transformation adaptation mechanism in infection establishment. As a result of analyzing host transformation related genes identified by the applicants, it was revealed that the two host transformation points of the vector infectious stage and the host infectivity stage are controlled by the same gene. We also screened novel host transformation related genes and developed methods for producing genetically modified protozoa.
|
