Taget molecule of antimicrobial peptides and disease control
| Project/Area Number |
25292178
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Tohoku University |
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Principal Investigator |
Isogai Emiko 東北大学, (連合)農学研究科(研究院), 教授 (80113570)
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| Co-Investigator(Kenkyū-buntansha) |
福田 智一 東北大学, (連合)農学研究科(研究院), 准教授 (40321640)
奥村 一彦 北海道医療大学, 歯学部, 准教授 (60194510)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 抗菌ペプチド / 薬剤耐性菌 / 腫瘍 / メタボローム解析 / アポトーシス / 自然免疫 / 抗菌活性 / 抗癌活性 / miRNA / 多剤耐性菌 / 分子標的 / 抗腫瘍活性 / 分子改変 / カセリシジン / 抗菌 / 抗癌 / 疾病予防 |
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| Outline of Final Research Achievements |
Antimicrobial peptides (AMPs) are host defense molecules of the innate immune system of all life forms. Recently, they have been characterized as multifunctional peptides.
In this study, we predicted the structure of persulcatusin (IP), which is an AMP derived from the tick. The structural integrity of IP is maintained by the S-S bond. IP showed strong antimicrobial activity against drug-resistant S. aureus but not toxic against mammalian and human cells such as fibroblasts, colon epithelial cells and erythrocytes. In particular against MRSA and VRSA, we found that IP had similar or stronger antimicrobial activity than VCM
We revealed that human cathelicidin antimicrobial peptide and its analogue, suppress the proliferation of colon cancer cells via apoptotic cell death.Large-scale metabolic profiling demonstrated remarkable differences between colon cancer cell lines treated with functional AMP and controls.
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Report
(5 results)
Research Products
(47 results)
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[Journal Article] miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway2017
Author(s)
Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E
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Journal Title
BMC Cancer
Volume: Jan 7;17(1):33
Issue: 1
Pages: 33-33
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Effective activity of synthetic antimicrobial peptides to antibiotic resistant Staphylococcus aureus.2016
Author(s)
Isogai E, Miyoshi N, Morozumi I, Kuroda K, Ihara K, Narita M, Isogai H, Hiramatsu K, Sasaki T
Organizer
21th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine
Place of Presentation
Greece, Athens, Metropolitan Hotel
Year and Date
2016-10-06
Related Report
Int'l Joint Research
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[Presentation] Mannose-binding lectine inhibits the motility of Salmonella through the alteration of membrane potential2015
Author(s)
Xu J, Nakamura S, Guo Y, Ihara K, Tomioka R, Masuda M, Yoneyama H, Kudo S, Isogai E
Organizer
MEEGID
Place of Presentation
Pastuer Institute, Paris, France
Year and Date
2015-10-21
Related Report
Int'l Joint Research
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