| Project/Area Number |
25292182
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Hidetoshi 酪農学園大学, 獣医学群, 教授 (00305905)
HASHIGUCHI Shuhei 鹿児島大学, 理工学研究科, 助教 (40295275)
HAGIWARA Katsuro 酪農学園大学, 獣医学群, 教授 (50295896)
MAEHARA Seiya 酪農学園大学, 獣医学群, 准教授 (50438363)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Yutaka 酪農学園大学, 獣医学群, 教授 (50382487)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 細菌感染症 / バクテリオファージ / 緑膿菌 / 黄色ブドウ球菌 / ファージセラピー / ワクチン / 薬剤耐性菌 / ウマ細菌性角膜炎 / 角膜炎 / 乳房炎 |
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| Outline of Final Research Achievements |
Antimicrobial resistance in bacteria is a concern not only in veterinary medicine, but also in general, worldwide. There is a demand for new strategies to treat bacterial infections. In this research, we investigated the ‘phage therapy for bacterial infection’ and ‘phage vaccine’. We examined the use of phage to treat horse bacterial keratitis as a research of phage therapy. We isolated phages toward P. aeruginosa causing horse keratitis. The phages in this study could completely prevent the keratitis caused by P. aeruginosa in a keratitis mouse model. In the phage vaccine, we constructed phage with surface antigen of Mycoplasma.
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