Analysis of the regulatory mechanisms of G protein-coupled receptor signaling
| Project/Area Number |
25293013
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Itoh Hiroshi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (10183005)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tetsuo 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (80433994)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | Gタンパク質 / GPCR / シグナル伝達 / 制御分子 |
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| Outline of Final Research Achievements |
We generated agonistic monoclonal antibodies against GPR56 and showed that the antibodies inhibit the migration of human glioma cells through Gq, Rho, and Rho kinase pathway. We found the possibility that GPR56 transmembrane region and latrophilin1 extracellular region forms a chimera receptor in GABAegic neurons, and latrotoxin, a latrophilin1 ligand, induces cell response mediated by the chimera receptor. We demonstrated that Ric-8 functions as a positive regulator for GPCR signaling system by regulating two post-translational modifications, ubiquitination and palmitoylation, on G proteins.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] Gαsユビキチン修飾を制御する分子機構の解析2015
Author(s)
鯉森貴行, 西村基喜, 竹田浩之, 多胡憲治, 小林 哲夫, 澤崎達也, 伊東 広
Organizer
第38回日本分子生物学会年会・第88回日本生化学大会
Place of Presentation
神戸ポートアイランド（兵庫県神戸市）
Year and Date
2015-12-01
Related Report
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[Presentation] Analysis of melecular mechanisms for Gαs ubiquitination2015
Author(s)
Koimori T, Nishimura M, Takeda H, Tago K, Kobayashi T, Sawazaki T, Itoh H
Organizer
Pontianak International Conference on Advanced Pharmaceutical Sciences (PICAPS) 2015 and the 6th Annual Symposium of Indonesian Society for Cancer Chemoprevention
Place of Presentation
Pontianak, Indonesia
Year and Date
2015-09-14
Related Report
Int'l Joint Research
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[Presentation] 膵管癌細胞における一次繊毛消失機構の解析2014
Author(s)
中薗 昴亮, 小林 哲夫, 徳田 澪, Brian David Dynlacht, 伊東 広
Organizer
第37回日本分子生物学会
Place of Presentation
パシフィコ横浜、神奈川県横浜市
Year and Date
2014-11-25 – 2014-11-27
Related Report
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