Global search for molecular target in translocation associated and non-translocation associated soft tissue sarcoma
| Project/Area Number |
25293088
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
ODA YOSHINAO 九州大学, 医学研究院, 教授 (70291515)
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| Co-Investigator(Kenkyū-buntansha) |
孝橋 賢一 九州大学, 医学(系)研究科(研究院), 講師 (10529879)
山元 英崇 九州大学, 大学病院, 准教授 (30404073)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 軟部肉腫 / 染色体転座 / キメラ遺伝子 / 分子標的 / シグナル伝達 / 癌精巣抗原 / FOXM1 / 滑膜肉腫 / 癌胎児抗原 / 横紋筋肉腫 / MPHOSPH1 / 悪性末梢神経鞘腫瘍 / NF1 / MN1 / MPOSPH1 / HSP90 / Akt-mTOR / CIC-DUX4 / BCOR-CCNB3 / 軟部血管線維腫 / AHRR-NCOA2 / 軟部腫瘍 / 孤立性線維性腫瘍 / 脱分化型脂肪肉腫 / 粘液・円形細胞型脂肪肉腫 / チロシンキナーゼ型受容体 / Akt-mTOR経路 / ケモカインレセプター / 転座関連肉腫 / 非転座関連肉腫 / apoptosis / 隆起性皮膚線維肉腫 / Akt-mTORシグナル経路 |
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| Outline of Final Research Achievements |
In solitary fibrous tumor, activation of several tyrosin kinase receptors and signal pathways were suggested to be correlated with tumor progression and proliferation. In recently identified translocation associated soft tissue tumors, such as angiofibroma of soft tissue and CIC-DUX4/BCOR-CCNB3 positive sarcoma, detailed clinicopathological and immunohistochemical features were elucidated. The expression of transcription factor, FOXOM1, had correlation with histological grade, poor prognosis and anti-tumor drug resistance in several kinds of soft tissue sarcomas including synovial sarcoma, rhabdomyosarcoma, leiomyoma and angiosarcoma. FOXM1 may be potential molecular target in these sarcomas. In synovial sarcoma and myxoid liposarcoma, cancer-testis antigen, NY-ESO-1 and PRAME were frequently expressed. This results is suggestive that NY-ESO-1 and PRAME may be effective immunotherapy target in synovial sarcoma and myxoid liposarcoma.
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Report
(5 results)
Research Products
(140 results)
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[Journal Article] Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4 and MAGEA12017
Author(s)
Iura K, Maekawa A, Kohashi K, Ishii T, Hirofumi B, Otsuka H, Yamada Y, Yamamoto H, Harimaya K, Iwamoto Y, Oda Y
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Journal Title
Hum Pathol
Volume: 61
Pages: 130-139
Related Report
Peer Reviewed
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[Journal Article] Activation of the Akt-mTOR and MAPK pathways in dedifferentiated liposarcomas.2016
Author(s)
Ishii T, Kohashi K, Iura K, Maekawa A, Bekki H, Yamada Y, Yamamoto H, Nabeshima K, Kawashima H, Iwamoto Y, Oda Y
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Journal Title
Tumour Biol.
Volume: 37(4)
Pages: 4767-4776
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Histological Spectrum of Angiofibroma of Soft Tissue: Histological and genetic analysis of 13 cases.2016
Author(s)
Yamada Y, Yamamoto H, Kohashi K, Ishii T, Iura K, Maekawa A, Bekki H, Otsuka H, Yamashita K, Tanaka H, Hiraki T, Mukai M, Shirakawa A, Shinnou Y, Jinno M, Yanai H, Taguchi K, Maehara Y, Iwamoto Y, Oda Y
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Journal Title
Histopathology
Volume: 69(3)
Pages: 459-469
Related Report
Peer Reviewed
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[Journal Article] Comprehensive Characterization of FN1-FGFR1 and Novel FN1-FGF1 Fusion Genes in a Large Series of Phosphaturic Mesenchymal Tumors2016
Author(s)
Lee JC, Su SY, Changou CA, Yang RS, Tsai KS, Collins MT, Orwoll ES, Lin CY, Chen SH, Shih SR, Lee CH, Oda Y, Billings SD, Li CF, Nielsen GP, Konishi E, Petersson F, Carpenter TO, Huang HY, Folpe AL.
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Journal Title
Mod Pathol
Volume: 29(11)
Pages: 1335-1346
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Prognostic impact of the activation status of Akt/mTOR pathway in synovial sarcoma2013
Author(s)
Setsu N, Kohashi K, Fushimi F, Endo M, Yamamoto H, Takahashi Y, Yamada Y, Ishii T, Yokoyama K, Iwamoto Y, Oda Y.
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Journal Title
Hum Pathol
Volume: 119
Pages: 3504-13
DOI
Related Report
Peer Reviewed
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[Presentation] J-4: Malignant myoepithelial tumor2013
Author(s)
Iura K, Kohashi K, Yamada Y, Maekawa A, Takahashi Y, Yamamaoto H, Oda Y: J-4: Malignant myoepithelial tumor
Organizer
The 13th Japanese-Korean Conjoint Slide Conference of the Bone and Soft Tissue
Place of Presentation
Beppu, Japan
Related Report
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