Involvement of PDGF in stem-cell based neural regeneration
Project/Area Number |
25293093
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | University of Toyama |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
石井 陽子 富山大学, 大学院医学薬学研究部(医学), 准教授 (00361949)
山本 誠士 富山大学, 大学院医学薬学研究部(医学), 助教 (10456361)
濱島 丈 富山大学, 大学院医学薬学研究部(医学), 助教 (80467092)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
|
Keywords | 血小板由来増殖因子 / 受容体 / 神経賦活因子 / 再生 / 虚血 / 髄鞘 / 稀突起膠細胞 / 幹細胞 / 増殖因子 / 間葉系幹細胞 / 血管周囲細胞 / 脱髄 |
Outline of Final Research Achievements |
Many of neurological diseases including stroke, trauma, and degenerative diseases are serious and incurable. In the present study, platelet-derived growth factor (PDGF) expressed in the brain was involved in the robust neurogenesis observed after experimentally induced stroke in mouse brain. Myelin is a crucial component of the brain for the neurological activities, and is often damaged in stroke, demyelinating diseases and in others. PDGF further mediated novel homeostatic control of myelin forming cells, in which, extensive cellular dynamics of myelin forming cells were induced by recruitment of new stem cells in a PDGF dependent manner in adult mouse brain. After all, the present project uncovered the involvement of PDGF in the novel regenerative mechanism of brain through multiple pathways. Therefore, PDGF is a hopeful target for regenerative medicine of the nervous system, and further studies are required to establish regenerative medicine of the nerve tissue.
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Report
(5 results)
Research Products
(137 results)
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[Journal Article] PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity2017
Author(s)
Y. Onogi, T. Wada, C. Kamiya, K. Inata, T. Matsuzawa, Y. Inaba, K. Kimura, H. Inoue, S. Yamamoto, Y. Ishii, D. Koya, H. Tsuneki, M. Sasahara, T. Sasaoka
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Journal Title
Diabetes
Volume: 4
Issue: 4
Pages: 1008-1021
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Overlapping memory trace indispensable for linking, but not recalling, individual memories.2017
Author(s)
Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M.,Watabe, A.M., Sasahara, M., Kato, F., Inokuchi, K.
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Journal Title
Science
Volume: 355
Issue: 6323
Pages: 398-403
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance.2016
Author(s)
Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
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Journal Title
Diabetes
Volume: 65(12)
Issue: 12
Pages: 3649-3659
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.2016
Author(s)
Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T.
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Journal Title
Endocrinology.
Volume: 157
Issue: 11
Pages: 4146-4157
DOI
Related Report
Peer Reviewed
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[Journal Article] Pericyte-fibroblast transition promotes tumor growth and metastasis.2016
Author(s)
Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, Hartman J, Religa P, Morikawa H, Ishii Y, Sasahara M, Larsson O, Cossu G, Cao R, Lim S, Cao Y.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 113(38)
Issue: 38
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice.2016
Author(s)
Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake, K, Takatsu K.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 23097-23097
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] PDGFR-β Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke.2016
Author(s)
Sato H, Ishii Y, Yamamoto S, Azuma E, Takahashi Y, Hamashima T, Umezawa A, Mori H, Kuroda S, Endo S, Sasahara M.
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Journal Title
Stem Cells.
Volume: 34
Issue: 3
Pages: 685-698
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Inflammation-induced endothelial cell-derived extracellukar vesicles modulate the cellular status of pericytes.2015
Author(s)
Yamamoto S., Niida S., Azuma E., Yanagibashi T., Muramatsu M., Huang TT., Sagara H., Higaki S., Ikutani M., Nagai Y., Takatsu K., Miyazaki K., Hamashima T., Mori H., Matsuda N., Ishii Y., Sasahara M.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 8505-8505
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] PDGFRα plays a crucial role in connective tissue remodeling.2015
Author(s)
Horikawa S, Ishii Y, Hamashima T, Yamamoto S, Mori H, Fujimori T, Shen J, Inoue R, Nishizono H, Itoh H, Majima M, Abraham D, Miyawaki T, Sasahara M.
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Journal Title
Scientific Reports
Volume: Dec 7;5
Issue: 1
Pages: 17948-17948
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity.2015
Author(s)
Sameshima A, Wada T, Ito T, Kashimura A, Sawakawa K, Yonezawa R, Tsuneki H, Ishii Y, Sasahara M, Saito S, Sasaoka T.
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Journal Title
Journal of Endocrinology
Volume: 227
Issue: 1
Pages: 25-36
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Discovery of power-law growth in the self-renewal of heterogeneous glioma stem cell populations.2015
Author(s)
Sugimori, M., Hayakawa, H., Boman, B.M., Fields, J.Z., Awaji, M., Kozano, H., Tamura, R., Yamamoto, S., Ogata, T., Yamada, M., Endo, S., Kurimoto, M. and Kuroda, S.
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Journal Title
PLoS ONE
Volume: 10
Issue: 8
Pages: e0135760-e0135760
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Aggressive transformation of anaplastic large cell lymphoma with increased number of ALK-translocated chromosomes.2015
Author(s)
Hoshino A, Nomura K, Hamashima T, Isobe T, Seki M, Hiwatari M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Takita J, Kanegane H.
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Journal Title
Int J Hematol.
Volume: 101
Issue: 2
Pages: 198-202
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multiple Colon Ulcers with Typical Small Intestinal Lesions Induced by Non-Steroidal Anti-Inflammatory Drugs2015
Author(s)
Akashi M, Ando T, Hamashima T, Yoshita H, Nanjo S, Mihara H, Fujinami H, Kajiura S, Nishikawa J, Miura Y, Hosokawa A, Sugiyama T.
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Journal Title
Internal Medicine
Volume: 54
Issue: 16
Pages: 1995-1999
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Journal Article] Review of small cell carcinoma of the kidney with focus on clinical and pathobiological aspects.2014
Author(s)
Kuroda N, Imamura Y, Hamashima T, Ohe C, Mikami S, Nagashima Y, Inoue K, Perez-Montiel D, Petersson F, Michal M, Hes O.
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Journal Title
Pol J Pathol
Volume: 65(1)
Pages: 15-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.2013
Author(s)
Ichikawa T, Hayashi R, Suzuki K, Imanishi S, Kambara K, Okazawa S, Inomata M, Yamada T, Yamazaki Y, Koshimizu Y, Miwa T, Matsui S, Usui I, Urakaze M, Matsuya Y, Sasahara M, Tobe K.
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Journal Title
Respirology
Volume: 18
Issue: 2
Pages: 332-339
DOI
Related Report
Peer Reviewed
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[Journal Article] Functional analysis of platelet-derived growth factor receptor-β in neural stem/progenitor cells.2013
Author(s)
Xu G, Shen J, Ishii Y, Fukuchi M, Dang TC, Zheng Y, Hamashima T, Fujimori T, Tsuda M, Funa K, Sasahara M.
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Journal Title
Neuroscience
Volume: 238
Pages: 195-208
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP1c Tg mice fed high-fat and high-fructose diet2013
Author(s)
Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kanasaki K, Kitada M, Koya D, Shimano H, Tsuneki H, Sasaoka
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 305
Issue: 11
Pages: E1415-E1425
DOI
Related Report
Peer Reviewed
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[Presentation] Depletion of platelet-derived growth factor receptor β prevented adipose tissue expansion and insulin resistance in diet-induced obesity.2015
Author(s)
Onogi Y, Wada T, Kamiya C, Inata K, Yamamoto S, Ishii Y, Sasahara M, Inaba Y, Kimura K, Inoue H, Nishizono H, Tsuneki H, Sasaoka T.
Organizer
Keystone Symposia: Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies
Place of Presentation
Kyoto, Japan
Year and Date
2015-10-25
Related Report
Int'l Joint Research
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[Presentation] Involvement of PDGFR-β in blood-brain barrier function after cerebral ischemia.2014
Author(s)
Shen J, Ishii Y, OuYang X , Yuan J , Zhu R , Xu G, Thanh Chung Dang , Hamashima T, Matsushima T, Yamamoto S, Sasahara M.
Organizer
The 18th International Vascular Biology Meeting
Place of Presentation
Kyoto
Year and Date
2014-04-14 – 2014-04-17
Related Report
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