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Intracellular transprt of influenza virus genome

Research Project

Project/Area Number 25293107
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Virology
Research InstitutionKyoto University (2015)
The University of Tokyo

Principal Investigator

Noda Takeshi  京都大学, ウイルス研究所, 教授 (00422410)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsインフルエンザ / インフルエンザウイルス / ウイルス
Outline of Final Research Achievements

Influenza virus M2 protein plays an important role in the packaging of influenza virus ribonucleoprotein complexes (RNPs) into progeny virions. Our purpose of this study is to identify M2-interactiong host proteins that are involved in intracellular transport of M2 proteins and RNPs. First we identified that GBF1 interacted with M2 protein. Down regulation of GBF1 specifically inhibited the virus replication. Further experiments revealed that GBF1 is responsible for assembly and virus particle formation, but not for intracellular transport of RNPs.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Crystal structure of Marburg virus VP40: matrix assembly and immunosuppression.2015

    • Author(s)
      Oda SI, Noda T, Wijesinghe KJ, Halfmann P, Bornholdt ZA, Abelson DM, Armbrust T, Stahelin RV, Kawaoka Y, Saphire EO.
    • Journal Title

      J Virol

      Volume: 90 Issue: 4 Pages: 1839-48

    • DOI

      10.1128/jvi.01597-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region2015

    • Author(s)
      Koga R, Sugita Y, Noda T, Yanagi Y, Ohno S.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 20 Pages: 10524-10531

    • DOI

      10.1128/jvi.01819-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Influenza virus-host interactome screen as a platform for antiviral drug development.2014

    • Author(s)
      Watanabe T, Kawakami E, Shoemaker JE, Lopes TJ, Matsuoka Y, Tomita Y, Kozuka-Hata H, Gorai T, Kuwahara T, Takeda E, Nagata A, Takano R, Kiso M, Yamashita M, Sakai-Tagawa Y, Katsura H, Nonaka N, Fujii H, Fujii K, Sugita Y, Noda T, Goto H, Fukuyama S, Watanabe S, Neumann G, Oyama M, Kitano H, Kawaoka Y.
    • Journal Title

      Cell Host and Microbe

      Volume: 16 Issue: 6 Pages: 795-805

    • DOI

      10.1016/j.chom.2014.11.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The configuration of viral ribonucleoprotein complexes within the influenza A virion.2013

    • Author(s)
      Yukihiko Sugita, Hiroshi Sagara Takeshi Noda and Yoshihiro Kawaoka
    • Journal Title

      Journal of Virology

      Volume: 87(23) Issue: 23 Pages: 12879-12884

    • DOI

      10.1128/jvi.02096-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The genome-packaging signal of the influenza A virus genome comprises a genome incorporation signal and a genome-bundling signal.2013

    • Author(s)
      Goto H, Muramoto Y, Noda T, Kawaoka Y.
    • Journal Title

      J Virol.

      Volume: 87 Issue: 21 Pages: 11316-11322

    • DOI

      10.1128/jvi.01301-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of H7N9 influenza A viruses isolated from humans.2013

    • Author(s)
      Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida N, Shirakura M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y , Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y
    • Journal Title

      Nature

      Volume: 501(7468) Issue: 7468 Pages: 551-5

    • DOI

      10.1038/nature12392

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] インフルエンザウイルスのゲノムパッケージング機構2014

    • Author(s)
      野田岳志、河岡義裕
    • Organizer
      日本薬学会 第134年会(熊本)
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genome packaging mechanism of influenza A viruses2013

    • Author(s)
      Takeshi Noda, Yoshihiro Kawaoka
    • Organizer
      The 9th China-Japan Joint Laboratory Workshop, China
    • Place of Presentation
      北京、中国
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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