| Project/Area Number |
25293109
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Nagoya University |
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Principal Investigator |
Kimura Hiroshi 名古屋大学, 医学(系)研究科(研究院), 教授 (30303621)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yoshinori 名古屋大学, 大学院医学系研究科, 准教授 (20373491)
SETO Masao 久留米大学, 医学部, 客員教授 (80154665)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | ウイルス発がん / EBウイルス / 遺伝子解析 / ＥＢウイルス / ウイルス初がん |
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| Outline of Final Research Achievements |
Hydroa vacciniforme-like lymphoma is a newly defined EBV-positive T-cell lymphoma. We performed microarray-based comparative genomic hybridization (array CGH) on 5 patients with hydroa vacciniforme-like lymphoma, and found a potentially deleted gene and an amplified gene, respectively. Next, we tried multiplex ligation probe amplification to confirm the gene modifications, but could not find deletion nor amplification. Furthermore, reverse-transcriptase polymerase chain reaction was done to clarify the expression of the corresponding genes, but neither decrease or increase of them was recognized. These results indicate that potentially disease-associated genes, which had been selected by array CGH, were not associated with hydroa vacciniforme-like lymphoma.
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