| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Both graft-derived T cells (gT) and HSC-derived reconstituted T cells have been implicated in chronic GVHD after hematopoietic stem cell transplantation. In a newly developed mouse model of chronic GVHD, gT with the potential to proliferate and produce cytokines were predominant in the target tissues during the observation period. Depletion of gT after transplantation increased the number of rT and did not ameliorate cGVHD, whereas depletion of rT activated gT and resulted in lethal exacerbation of cGVHD. Identification of the molecular mechanisms underlying the interaction between TG and THSC is likely to lead to novel therapeutic strategies for the prevention and treatment of cGVHD.
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