2015 Fiscal Year Final Research Report
Cellular and molecular bases for chronic GVHD
Project/Area Number |
25293113
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Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Immunology
|
Research Institution | The University of Tokyo |
Principal Investigator |
Matsushima Kouji 東京大学, 医学(系)研究科(研究院), 教授 (50222427)
|
Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Shinichi 金沢大学, 医学系, 教授 (00313099)
UEHA Satoshi 東京大学, 大学院医学系研究科, 講師 (00447385)
SHIMAOKA Takeshi 東京大学, 大学院医学系研究科, 助教 (90422279)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 移植免疫 / 造血幹細胞移植 / GVHD / T細胞 |
Outline of Final Research Achievements |
Both graft-derived T cells (gT) and HSC-derived reconstituted T cells have been implicated in chronic GVHD after hematopoietic stem cell transplantation. In a newly developed mouse model of chronic GVHD, gT with the potential to proliferate and produce cytokines were predominant in the target tissues during the observation period. Depletion of gT after transplantation increased the number of rT and did not ameliorate cGVHD, whereas depletion of rT activated gT and resulted in lethal exacerbation of cGVHD. Identification of the molecular mechanisms underlying the interaction between TG and THSC is likely to lead to novel therapeutic strategies for the prevention and treatment of cGVHD.
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Free Research Field |
医歯薬学
|