Host-microbe interaction mediated by intestinal M cells
| Project/Area Number |
25293114
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Keio University (2014-2015)
The University of Tokyo (2013) |
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Principal Investigator |
Hase Koji 慶應義塾大学, 薬学部, 教授 (20359714)
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| Co-Investigator(Renkei-kenkyūsha) |
MIMURO Hitomi 東京大学, 医科学研究所, 准教授 (80396887)
FURUSAWA Yukihiro 富山県立大学, 工学部, 講師 (80632306)
KIMURA Shunsuke 北海道大学, 医学研究科, 助教 (40444525)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 粘膜免疫 / M細胞 / 粘膜免疫学 / Ｍ細胞 / パイエル板 |
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| Outline of Final Research Achievements |
It remains unknown whether M-dependent antigen uptake also contributes to cellular immunity against mucosal pathogens. Here we investigated the contribution of M cells to Th17-dependent cellular immunity. Wild type (WT) and M-cell-null mice were orally infected with Citrobacter rodentium. After the infection, M-cell-null mice developed more severe infectious colitis compared to WT mice, as evidenced by exacerbation of body weight loss and fecal clinical scores. Importantly, colonic Th17 cells were decreased in M-cell-null mice compared to WT mice at the early phase of infection. In contrast, under the physiological conditions, there was no significant difference in the number of colonic Th17 cells between the two groups. Collectively, these results suggested that M-cell-dependent antigen uptake plays a key role in the protection against C. rodentium infection by facilitating antigen-specific Th17 induction.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity2016
Author(s)
1.Li, Y., Takahashi, Y., Fujii, S., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K., Wang, J.-Y.
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Journal Title
Nature Commun.
Volume: 7
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues2014
Author(s)
Yuuki Obata, Shunsuke Kimura, Gaku Nakato, Keito Iizuka, Yurika Miyagawa, Yutaka Nakamura, Yukihiro Furusawa, Machiko Sugiyama, Keiichiro Suzuki, Masashi Ebisawa, Yumiko Fujimura, Hisahiro Yoshida, Toshihiko Iwanaga, Koji Hase and Hiroshi Ohno.
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Journal Title
EMBO Reports
Volume: 12
Issue: 12
Pages: 1297-1304
DOI
Related Report
Peer Reviewed
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[Journal Article] The epigenetic regulator Uhrf1 facilitates proliferation and maturation of colonic regulatory T cells2014
Author(s)
Yuuki Obata*, Yukihiro Furusawa*, Takaho A. Endo, Jafar Sharif, Daisuke Takahashi, Koji Atarashi, Manabu Nakayama, Satoshi Onawa, Yumiko Fujimura, Masumi Takahashi, Tomokatsu Ikawa, Takeshi Otsubo, Yuki I. Kawamura, Taeko Dohi, Shoji Tajima, Osamu Ohara, Kenya Honda, Shohei Hori, Hiroshi Ohno, Haruhiko Koseki and Koji Hase. 【* : 筆頭筆者】
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Journal Title
Nature Immunology
Volume: 15
Issue: 6
Pages: 571-579
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Commensal microbe-derived butyrate induces colonic regulatory T cells2013
Author(s)
Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Takaho A. Endo, Gaku Nakato, Daisuke Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko N. Fukuda, Shinnosuke Murakami, Eiji Miyauchi, Shingo Hino, Koji Atarashi, Satoshi Onawa, Yumiko Fujimura, Trevor Lockett, Julie M. Clarke, David L. Topping, Masaru Tomita, Shohei Hori, Osamu Ohara, Tatsuya Morita, Haruhiko Koseki, J un Kikuchi, Kenya Honda, Koji Hase and Hiroshi Ohno
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Journal Title
Nature
Volume: 506
Issue: 7480
Pages: 446-450
DOI
Related Report
Peer Reviewed
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[Journal Article] AP-1B-Mediated Protein Sorting Regulates Polarity and Proliferation of Intestinal Epithelial Cells in Mice2013
Author(s)
Koji Hase, Fubito Nakatsu, Masumi Ohmae, Kahushi Sugihara, Noriko Shioda, Daisuke Takahashi, Yuuki Obata, Yukihiro Furusawa, Yumiko Fujimura, Taisuke Yamashita, Shinji Fukuda, Hiroshi Okamoto, Masahide Asano, Shigenobu Yonemura and Hiroshi Ohno.
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Journal Title
Gastroenterology
Volume: 145
Issue: 3
Pages: 625-635
DOI
Related Report
Peer Reviewed
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