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Establishment of cancer diagnosis system by multi-platform metabolomics

Research Project

Project/Area Number 25293131
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionKobe University

Principal Investigator

YOSHIDA MASARU  神戸大学, 医学(系)研究科(研究院), 准教授 (00419475)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywordsメタボロミクス / 質量分析計 / バイオマーカー / がん
Outline of Final Research Achievements

In this study, we analyze serum from cancer patients by using gas chromatograph mass spectrometry and liquid chromatograph mass spectrometry, and then validated the possibility for the cancer profiling diagnosis system based on the alterations in the levels of blood metabolites. We established the four kinds of the analyzing platform for blood metabolites, and then analyzed serum from cancer patients by using these platforms. As a result, we could find the candidates for metabolite biomarkers, and furthermore could suggested the new diagnosis procedure called ‘2-phase screening’.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (14 results)

All 2016 2015 2014 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] Pancreatic cancer screening using a multiplatform human serum metabolomics system2016

    • Author(s)
      Sakai A., Suzuki M., Kobayashi T., Nishiumi S., Yamanaka K., Hirata Y., Nakagawa T., Azuma T., Yoshida M.
    • Journal Title

      Biomarkers in Medicine

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] LC-MS/MS-based metabolome analysis detected changes in the metabolic profiles of small and large intestinal adenomatous polyps in ApcMin/+ mice2016

    • Author(s)
      Suzuki M., Nishiumi S., Kobayashi T., Azuma T., Yoshida M.
    • Journal Title

      Metabolomics

      Volume: 12 Issue: 4 Pages: 1-9

    • DOI

      10.1007/s11306-016-0988-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Supercritical fluid extraction as a preparation method for mass spectrometry of dried blood spots.2014

    • Author(s)
      Matsubara A, Izumi Y, Nishiumi S, Suzuki M, Azuma T, Fukusaki E, Bamba T, Yoshida M.
    • Journal Title

      J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.

      Volume: 969 Pages: 199-204

    • DOI

      10.1016/j.jchromb.2014.08.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomics for Biomarker Discovery in Gastroenterological Cancer2014

    • Author(s)
      Nishiumi S., Suzuki M., Kobayashi T., Matsubara A., Azuma T., Yoshida M.
    • Journal Title

      Metabolites

      Volume: 4 Issue: 3 Pages: 547-571

    • DOI

      10.3390/metabo4030547

    • NAID

      120005619642

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Metabolome analysis for discovering biomarkers of gastroenterological cancer2014

    • Author(s)
      Suzuki M, Nishiumi S, Matsubara A, Azuma T, Yoshida M
    • Journal Title

      J Chromatogr B Analyt Technol Biomed Life Sci.

      Volume: 未定 Pages: 59-69

    • DOI

      10.1016/j.jchromb.2014.02.042

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Metabolome analysis for discovering Biomarkers of Gastrointestinal Cancers2015

    • Author(s)
      Masaru Yoshida
    • Organizer
      2015 Mass Spectrometry for Clinical Diagnosis
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メタボロミクスによるがん診断法の開発と自動化の試み2015

    • Author(s)
      吉田優
    • Organizer
      第15回日本質量分析学会北海道談話会・研究会
    • Place of Presentation
      北海同大学(北海道)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] メタボロミクスによる新しい臨床検査の展開2015

    • Author(s)
      吉田優
    • Organizer
      日本臨床検査自動化学会第47回大会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 血清メタボローム解析によるがんバイオマーカー探索2015

    • Author(s)
      吉田優
    • Organizer
      第28回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      長崎大学(長崎)
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] メタボロミクスによるがんバイオマーカー探索2015

    • Author(s)
      吉田優
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫、神戸)
    • Year and Date
      2015-03-25 – 2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Metabolomics analysis for medical research2014

    • Author(s)
      Masaru Yoshida
    • Organizer
      ISSX・JSSX CAMS2014
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-10-19 – 2014-10-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血清メタボロミクスによるがんバイオマーカー探索2014

    • Author(s)
      吉田優
    • Organizer
      第2回がんと代謝研究会
    • Place of Presentation
      東京理科大学(東京、葛飾区)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Remarks] 神戸大学大学院医学研究科内科系講座病因病態解析学分野

    • URL

      http://www.med.kobe-u.ac.jp/metabo/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 神戸大学大学院医学研究科内科学講座消化器内科学分野ホームページ

    • URL

      http://www.med.kobe-u.ac.jp/gi/index.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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