Epidemiology of frailty in older people
Project/Area Number |
25293141
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
三木 哲郎 京都大学, 医学(系)研究科(研究院), 教授 (00174003)
松田 文彦 京都大学, 医学(系)研究科(研究院), 教授 (50212220)
中山 健夫 京都大学, 医学(系)研究科(研究院), 教授 (70217933)
伊賀瀬 道也 愛媛大学, 医学部附属病院, 准教授 (90314955)
小原 克彦 愛媛大学, 医学(系)研究科(研究院), 准教授 (30260384)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
|
Keywords | 高齢者 / フレイルティ / サルコペニア / 循環器疾患 / オミックス解析 |
Outline of Final Research Achievements |
A most important health burden in an era of population aging is frailty in older people, a composite phenotype of physical fragility and impairment. Clarifying interrelationship among factors of frailty, as well as risk factors for being frailty including lifestyle habits, are required for successful aging. We analyzed a datasets of population-based cohort studies to clarify these issues. Results of this study, i.e., clarifying associations between blood pressure dysregulation and asymptomatic cerebrovascular diseases, postural instability and cognitive impairment etc., would be helpful to further understanding etiology of frailty in older people.
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Report
(5 results)
Research Products
(115 results)
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[Journal Article] Combined association of clinical and lifestyle factors with non-restorative sleep: The Nagahama Study.2017
Author(s)
Matsumoto T, Tabara Y, Murase K, Takahashi Y, Setoh K, Kawaguchi T, Muro S, Kadotani H, Kosugi S, Sekine A, Yamada R, Nakayama T, Mishima M, Matsuda F, Chin K.
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Journal Title
PLoS One.
Volume: 12
Issue: 3
Pages: e0171849-e0171849
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Risks and Cough-Aggravating Factors in Prolonged Cough: Epidemiological Observations from the Nagahama Cohort Study.2017
Author(s)
Matsumoto H, Izuhara Y, Niimi A, Tabara Y, Nagasaki T, Kanemitsu Y, Murase K, Oguma T, Ito I, Muro S, Sekine A, Matsuda F, Kosugi S, Nakayama T, Chin K, Mishima M; Nagahama Study Collaboration Group..
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Journal Title
Ann Am Thorac Soc.
Volume: Feb 10.
Issue: 5
Pages: 698-705
DOI
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Peer Reviewed / Open Access
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[Journal Article] Self-reported quality of sleep is associated with physical strength among community-dwelling young-old adults.2017
Author(s)
Malinowska KB, Ikezoe T, Ichihashi N, Arai H, Murase K, Chin K, Kawaguchi T, Tabara Y, Nakayama T, Matsuda F, Tsuboyama T.
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Journal Title
Geriatr Gerontol Int.
Volume: -
Issue: 11
Pages: 1808-1813
DOI
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on Plasma Resistin: Genotype and DNA Methylation.2017
Author(s)
Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Ohyagi Y, Kawamoto R, Kohara K, Miki T, Osawa H.
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Journal Title
J Clin Endocrinol Metab.
Volume: 102
Issue: 3
Pages: 884-892
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.2016
Author(s)
Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H.
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Journal Title
Physiol Genomics.
Volume: 48
Issue: 11
Pages: 874-881
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population: The Nagahama Study.2016
Author(s)
Muro S, Tabara Y, Matsumoto H, Setoh K, Kawaguchi T, Takahashi M, Ito I, Ito Y, Murase K, Terao C, Kosugi S, Yamada R, Sekine A, Nakayama T, Chin K, Mishima M, Matsuda F; Nagahama Study Group.
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Journal Title
Medicine (Baltimore).
Volume: 95(15)
Issue: 15
Pages: e3371-e3371
DOI
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Peer Reviewed / Open Access
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[Journal Article] Mouth Breathing, another Risk Factor for Asthma: the Nagahama Study.2016
Author(s)
Yumi I, Matsumoto H, Nagasaki T, Kanemitsu Y, Murase K, Ito I, Oguma T, Muro S, Asai K, Tabara Y, Takahashi K, Bessho K, Sekine A, Kosugi S, Yamada R, Nakayama T, Matsuda F, Niimi A, Chin K, Mishima M; Nagahama Study Group.
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Journal Title
Allergy
Volume: 未定
Issue: 7
Pages: 1031-1036
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a general population: The Nagahama Study2016
Author(s)
Yasuharu Tabara, Yoshimitsu Takahashi, Kazuya Setoh, Takahisa Kawaguchi, Norimoto Gotoh, Chikashi Terao, Ryo Yamada, Shinji Kosugi, Akihiro Sekine, Takeo Nakayama, Fumihiko Matsuda, on behalf of the Nagahama Study group.
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Journal Title
M E T A B O L I S M C L I N I C A L A N D E X P E R I M E N T A L
Volume: 65
Issue: 1
Pages: 66-72
DOI
NAID
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Peer Reviewed / Open Access
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[Journal Article] Mapping the genetic diversity of HLA haplotypes in the Japanese populations.2015
Author(s)
W. Y. Saw, X. Liu, C. C. Khor, F. Takeuchi, T. Katsuya, R. Kimura, T. Nabika, T. Ohkubo, Y. Tabara, K. Yamamoto, M. Yokota, Japanese Genome Variation Consortium, Y. Y. Teo, and N. Kato
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 17855-17855
DOI
NAID
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Knee Pain and Low Back Pain Additively Disturb Sleep in the General Population: A Cross-Sectional Analysis of the Nagahama Study.2015
Author(s)
Murase K, Tabara Y, Ito H, Kobayashi M, Takahashi Y, Setoh K, Kawaguchi T, Muro S, Kadotani H, Kosugi S, Sekine A, Yamada R, Nakayama T, Mishima M, Matsuda S, Matsuda F, Chin K.
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Journal Title
PLoS One
Volume: 10
Issue: 10
Pages: e0140058-e0140058
DOI
NAID
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Peer Reviewed / Open Access
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[Journal Article] Descriptive epidemiology of spot urine sodium-to-potassium ratio clarified close relationship with blood pressure level: the Nagahama study.2015
Author(s)
Tabara Y, Takahashi Y, Kumagai K, Setoh K, Kawaguchi T, Takahashi M, Muraoka Y, Tsujikawa A, Gotoh N, Terao C, Yamada R, Kosugi S, Sekine A, Yoshimura N, Nakayama T, Matsuda F; Nagahama study group.
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Journal Title
J Hypertens
Volume: 33
Issue: 12
Pages: 2407-13
DOI
NAID
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Peer Reviewed / Open Access
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[Journal Article] Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis.2015
Author(s)
Terao C, Yamakawa N, Yano K, Markusse IM, Ikari K, Yoshida S, Furu M, Hashimoto M, Ito H, Fujii T, Ohmura K, Murakami K, Takahashi M, Hamaguchi M, Tabara Y, Taniguchi A, Momohara S, Raychaudhuri S, Allaart CF, Yamanaka H, Mimori T, Matsuda F.
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Journal Title
Arthritis Rheumatol.
Volume: 67
Issue: 12
Pages: 3113-3123
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Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.2015
Author(s)
146.Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels. Setoh K, Terao C, Muro S, Kawaguchi T, Tabara Y, Takahashi M, Nakayama T, Kosugi S, Sekine A, Yamada R, Mishima M, Matsuda F.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 7754-7754
DOI
NAID
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Peer Reviewed / Open Access
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[Journal Article] Association Between Genetic Variation in the <i>SCN10A</i> Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy2015
Author(s)
Iio C, Ogimoto A, Nagai T, Suzuki J, Inoue K, Nishimura K, Uetani T, Okayama H, Okura T, Shigematsu Y, Tabara Y, Kohara K, Miki T, Hamada M, Higaki J.
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Journal Title
International Heart Journal
Volume: 56
Issue: 4
Pages: 421-427
DOI
NAID
ISSN
1349-2365, 1349-3299
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Peer Reviewed / Open Access
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[Journal Article] Takayasu arteritis and ulcerative colitis -high concurrence ratio and genetic overlap.2015
Author(s)
Terao C, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K, Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, Matsuda F.
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Journal Title
Arthritis Rheumatol.
Volume: -
Issue: 8
Pages: 2226-2232
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Peer Reviewed
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[Journal Article] Association of postural instability with asymptomatic cerebrovascular damage and cognitive decline: the Japan Shimanami Health Promoting Program study.2015
Author(s)
Tabara Y, Okada Y, Ohara M, Uetani E, Kido T, Ochi N, Nagai T, Igase M, Miki T, Matsuda F, Kohara K.
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Journal Title
Stroke.
Volume: 46
Issue: 1
Pages: 16-22
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Central blood pressure relates more strongly to retinal arteriolar narrowing than brachial blood pressure: the Nagahama Study.2015
Author(s)
Kumagai K1, Tabara Y, Yamashiro K, Miyake M, Akagi-Kurashige Y, Oishi M, Yoshikawa M, Kimura Y, Tsujikawa A, Takahashi Y, Setoh K, Kawaguchi T, Terao C, Yamada R, Kosugi S, Sekine A, Nakayama T, Matsuda F, Yoshimura N; Nagahama Study group
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Journal Title
J Hypertens
Volume: 33
Issue: 2
Pages: 323-9
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Peer Reviewed / Open Access
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[Journal Article] The KSS 2011 reflects symptoms, physical activities, and radiographic grades in a Japanese population.2015
Author(s)
Taniguchi N, Matsuda S, Kawaguchi T, Tabara Y, Ikezoe T, Tsuboyama T, Ichihashi N, Nakayama T, Matsuda F, Ito H.
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Journal Title
Clin Orthop Relat Res.
Volume: 473
Pages: 70-75
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Missense variants of the alanine: glyoxylate aminotransferase 2 gene correlated with carotid atherosclerosis in the Japanese population.2014
Author(s)
Yoshino Y, Kohara K, Abe M, Ochi S, Mori Y, Yamashita K, Igase M, Tabara Y, Mori T, Miki T, Ueno S.
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Journal Title
J Biol Regul Homeost Agents.
Volume: 28
Pages: 605-614
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[Journal Article] Gastroesophageal reflux disease symptoms and dietary behaviors are significant correlates of short sleep duration in the general population: The Nagahama Study.2014
Author(s)
Murase, K., Tabara, Y., Takahashi, Y., Muro, S., Yamada, R., Setoh, K., Kawaguchi, T., Kadotani, H., Kosugi, S., Sekine, A., Nakayama, T., Mishima, M., Chiba, T., Chin, K., Matsuda, F
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Journal Title
Sleep
Volume: 37
Issue: 11
Pages: 1809-15
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[Journal Article] ffects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adultpopulation.2014
Author(s)
Terao C, Ohmura K, Ikari K, Kawaguchi T, Takahashi M, Setoh K, Nakayama T,Kosugi S, Sekine A, Tabara Y, Taniguchi A, Momohara S, Yamanaka H, Yamada R,Matsuda F, Mimori T; Nagahama Study Group
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Journal Title
Arthritis Care Res (Hoboken)
Volume: 66
Issue: 12
Pages: 1818-27
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[Journal Article] A genome-wide association study of serum levels of prostate specific antigen in the Japanese population.2014
Author(s)
Chikashi Terao, Naoki Terada, Keitaro Matsuo, Takahisa Kawaguchi, Koji Yoshimura, Norio Hayashi, Masakazu Shimizu, Norihito Soga, Meiko Takahashi, Nagahama Cohort Study Group, Yoshihiko Kotoura, Ryo Yamada, Osamu Ogawa, Fumihiko Matsuda.
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Journal Title
J Med Genet
Volume: 51
Issue: 8
Pages: 530-536
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[Journal Article] Postprandial hypotension as a risk marker for asymptomatic lacunar infarction.2014
Author(s)
Tabara Y, Okada Y, Uetani E, Nagai T, Igase M, Kido T, Ochi N, Ohara M, Takita R, Kohara K, Miki T.
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Journal Title
J Hypertens
Volume: 32
Issue: 5
Pages: 1084-1090
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Airflow limitation in smokers is associated with arterial stiffness: The nagahama study2014
Author(s)
Tabara, Y., Muro, S., Takahashi, Y., Setoh, K., Kawaguchi, T., Terao, C., Yamada, R.,. . . Nagahama Study Group
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Journal Title
Atherosclerosis
Volume: 232
Issue: 1
Pages: 59-64
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[Journal Article] Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy.2013
Author(s)
Nakata I, Yamashiro K, Kawaguchi T, Gotoh N, Nakanishi H, Akagi-Kurashige Y, Miyake M, Tsujikawa A, Oishi A, Saito M, Iida T, Yamada R, Matsuda F, Yoshimura N; Nagahama Study Group.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 54
Issue: 9
Pages: 6068-6073
DOI
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[Journal Article] Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population2013
Author(s)
Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I,
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Journal Title
American Journal of Human Genetics
Volume: 93
Issue: 2
Pages: 289-297
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[Journal Article] Mastication and risk for diabetes in a Japanese population: a cross-sectional study.2013
Author(s)
Yamazaki T, Yamori M, Asai K, Nakano-Araki I, Yamaguchi A, Takahashi K, Sekine A, Matsuda F, Kosugi S, Nakayama T, Inagaki N, Bessho K; Nagahama Study Collaboration Group.
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Journal Title
PLoS One.
Volume: 8
Issue: 6
Pages: e64113-e64113
DOI
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[Journal Article] Association of longer QT interval with arterial waveform and lower pulse pressure amplification: the Nagahama Study.2013
Author(s)
Tabara Y, Takahashi Y, Kohara K, Setoh K, Kawaguchi T, Terao C, Igase M, Yamada R, Kosugi S, Sekine A, Miki T, Nakayama T, Matsuda F; Nagahama Study Group.
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Journal Title
Am J Hypertens
Volume: 26
Issue: 8
Pages: 973-980
DOI
NAID
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Peer Reviewed
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[Journal Article] Increased aortic wave reflection and smaller pulse pressure amplification in smokers and passive smokers confirmed by urinary cotinine levels: the Nagahama Study.2013
Author(s)
Yasuharu Tabara, Yoshimitsu Takahashi, Kazuya Setoh, Shigeo Muro, Takahisa Kawaguchi, Chikashi Terao, Shinji Kosugi, Akihiro Sekine, Ryo Yamada, Michiaki Mishima, Takeo Nakayama, and Fumihiko Matsuda, on behalf of the Nagahama Study Group
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Journal Title
International Journal of Cardiology
Volume: 168(3)
Issue: 3
Pages: 2673-2677
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Genotype-Phenotype Correlations in Dilated-Phase Hypertrophic Cardiomyopathy Patients with Cardiac Resynchronization Therapy or Left Ventricular Assist Device by Next Generation Sequencing.2016
Author(s)
Ogimoto A, Tokunaga N, Suzuki J, Inoue K, Nishimura K, Nagai T, Aono J, Uetani T, Higashi H, Ohkura T, Tabara Y, Higaki J
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台
Year and Date
2016-03-18
Related Report
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[Presentation] Targeted Next Generation Sequencing of 174 Genes in Patients with Cardiomyopathy for Future Clinical Utility2016
Author(s)
Ogimoto A, Tokunaga N, Suzuki J, Inoue K, Nishimura K, Nagai T, Aono J, Uetani T, Iio C, Ohkura T, Tabara T, Higaki J.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台
Year and Date
2016-03-18
Related Report
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[Presentation] Association of serum free fatty acid level with reduced reflection pressure wave magnitude and central blood pressure: The Nagahama Study.2015
Author(s)
Tabara Y, Takahashi Y, Kawaguchi T, Setoh K, Terao C, Yamada R, Kosugi S, Sekine A, Nakayama T, Matsuda F, on behalf of the Nagahama Study Group.
Organizer
25th European Meeting on Hypertension and Cardiovascular Protection.
Place of Presentation
ミラノ
Year and Date
2015-06-12
Related Report
Int'l Joint Research
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[Presentation] 高齢者フレイルの臨床的特徴2014
Author(s)
小原克彦・田原康玄・伊賀瀬道也・三木哲郎
Organizer
第37回日本高血圧学会総会
Place of Presentation
横浜
Year and Date
2014-10-17 – 2014-10-19
Related Report
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[Presentation] Increased aortic wave reflection and smaller pulse pressure amplification in smokers and passive smokers confirmed by urinary cotinine levels2014
Author(s)
Tabara Y, Takahashi Y, Setoh K, Muro S, Kawaguchi T, Terao C, Kosugi S, Sekine A, Yamada R, Mishima M, Nakayama T, Matsuda F
Organizer
Joint Meeting ESH-ISH Hypertension Athens 2014
Place of Presentation
アテネ
Year and Date
2014-06-13 – 2014-06-16
Related Report
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[Presentation] Relatively lower central aortic pressure in subjects with impaired insulin sensitivity and resistance: The Toon Health Study2014
Author(s)
Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
Organizer
Joint Meeting ESH-ISH Hypertension Athens 2014
Place of Presentation
アテネ
Year and Date
2014-06-13 – 2014-06-16
Related Report
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