| Project/Area Number |
25293147
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Kokubo Yoshihiro 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Keywords | 心房細動 / リスクスコア－ / 疫学 / 危険因子 / リスクスコアー / 追跡研究 / 収縮期血圧 / body mass index / 過剰飲酒 / 喫煙 / 生活習慣 / リスクスコア― |
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| Outline of Final Research Achievements |
A total of 6,906 participants (30-84 years old) initially free of AF were prospectively followed up for incident AF in the Suita Study. Standard 12-lead ECGs were obtained from all subjects in the supine position. Participants were diagnosed with AF if AF or atrial flutter was present on ECGs obtained during a biannual routine health examination or if AF was indicated as a present illness by either annual questionnaires responses or participants' medical records during follow-up. Cox proportional hazard ratios were analyzed.
In 88,663 person-years of follow-up, 253 incident AF events occurred. Age, sex, body mass index and systolic blood pressure (systolic prehypertension with overweight or obesity, systolic hypertension with normal weight/overweight or obesity), valvular disease and/or heart murmur, ischemic heart disease, smoking, and excessive drinking were associated with incident AF (C-statistic 0.73; 95% confidence intervals, 0.70-0.75).
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