The development of a novel therapeutic strategies for chronic kidney disease by the targeting on the renal mitochondrial oxidative stress.

• Project/Area Number: 25293193
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: MORI TAKEFUMI 東北大学, 医学(系)研究科(研究院), 准教授 (40375001)
• Co-Investigator(Kenkyū-buntansha): ITO SADAYOSHI 東北大学, 大学院医学系研究科, 教授 (40271613) ; KIYOMOTO HIDEYASU 東北大学, メディカルメガバンク機構, 教授 (00304585) ; OHSAKI YUSUKE 東北大学, 大学院医学系研究科, 助教 (40509212)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 腎臓 / 酸化ストレス / ミトコンドリア / 蛍光イメージング / アンジオテンシンII / グルコース / 低酸素 / 虚血再灌流 / 腎臓髄質血流 / 腎障害 / ヘンレのループ太い上行脚 / ナトリウム再吸収 / カルボニルストレス

Outline of Final Research Achievements

The effects on the reactive oxygen species production of physiological stimuli were assessed in renal medullary thick ascending limb of loop of Henle (mTAL) in rats. Angiotensin II stimulation increased the intracellular ROS concentration through mitochondrial ROS production in mTAL. High concentration of glucose stimulated the mitochondrial ROS production via the glucose degradation products. Hypoxia also increased mitochondrial ROS production. The administration of mitoTEMPO, which is scavenger of mitochondrial ROS, attenuated the reduction of renal medullary blood flow and oxygen concentration induced by ischemia/reperfusion.

Research Products

• [Journal Article] Urinary angiotensinogen excretion is associated with blood pressure in obese young adults. (2016)
  • Author(s): Sato E, Mori T, Satoh M, Fujiwara M, Nakamichi Y, Oba I, Ogawa S, Kinouchi Y, Sato H, Ito S, Hida W.
  • Journal Title: Clin Exp Hypertens. Volume: 38 Issue: 2 Pages: 203-208
  • DOI: 10.3109/10641963.2015.1081219
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diuretic Usage for Protection against End-Organ Damage in Liver Cirrhosis and Heart Failure. (2016)
  • Author(s): Mori T, Osaki Y, Oba-Yabana I, Ito S.
  • Journal Title: Hepatol Res. Volume: 印刷中 Issue: 1 Pages: 11-22
  • DOI: 10.1111/hepr.12700
  • Peer Reviewed / Open Access
• [Journal Article] Glucose and Insulin Response to Peritoneal Dialysis Fluid in Diabetic and Nondiabetic Peritoneal Dialysis Patients. (2015)
  • Author(s): Oba I, Mori T, Chida M, Kurasawa N, Naganuma E, Sato E, Koizumi K, Sato S, Tsuchikawa M, Ito S.
  • Journal Title: Adv Perit Dial. Volume: 31 Pages: 11-16
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Home Blood Pressure and Body Composition by Bioimpedance Monitoring in Patients Undergoing Peritoneal Dialysis. (2015)
  • Author(s): Kurasawa N, Mori T, Naganuma E, Sato E, Koizumi K, Sato S, Oba I, Tsuchikawa M, Ito S.
  • Journal Title: Adv Perit Dial. Volume: 31 Pages: 38-44
  • Peer Reviewed / Open Access
• [Journal Article] Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron. (2015)
  • Author(s): Rong R, Ito O, Mori N, Muroya Y, Tamura Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M.
  • Journal Title: Peptides. Volume: 63 Pages: 156-62
  • DOI: 10.1016/j.peptides.2014.12.007
  • Peer Reviewed / Open Access
• [Journal Article] Association of aldosterone-to-renin ratio with hypertension differs by sodium intake: the Ohasama study. (2015)
  • Author(s): Satoh M, Kikuya M, Hosaka M, et al.
  • Journal Title: Am J Hypertens. Volume: 28 Issue: 2 Pages: 208-215
  • DOI: 10.1093/ajh/hpu115
  • Peer Reviewed / Open Access
• [Journal Article] Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension. (2015)
  • Author(s): Cowley AW Jr, Abe M, Mori T, O'Connor PM, Ohsaki Y, Zheleznova NN
  • Journal Title: Am J Physiol Renal Physiol Volume: 308 Issue: 3 Pages: F179-F197
  • DOI: 10.1152/ajprenal.00455.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A functional (pro)renin receptor is expressed in human lymphocytes and monocytes. (2015)
  • Author(s): Narumi K, Hirose T, Sato E, Mori T, Kisu K, Ishikawa M, Totsune K, Ishii T, Ichihara A, Nguyen G, Sato H, Ito S.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 308 Issue: 5 Pages: F487-F499
  • DOI: 10.1152/ajprenal.00206.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline assessed by self-measurement of blood pressure at home : the Ohasama Study (2014)
  • Author(s): Satoh M, Hosaka M, et al.
  • Journal Title: Clin Exp Hypertens. Volume: 36 Issue: 2 Pages: 108-114
  • DOI: 10.3109/10641963.2014.892121
  • Peer Reviewed
• [Journal Article] 利尿薬抵抗性の病態と対策 (2014)
  • Author(s): 森 建文、大場郁子、小泉賢治、古庄正英、伊藤貞嘉
  • Journal Title: 呼吸と循環 Volume: 62 Pages: 410-416
• [Journal Article] Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats. (2013)
  • Author(s): Chen x, Mori T, Guo Q, Hu C, Ohsaki Y, Yoneki Y, Zhu W, Jiang Y, Endo S, Nakayama K, Ogawa S, Nakayama M, Miyata T, Ito S
  • Journal Title: Hypertens Res. Volume: (印刷中) Issue: 4 Pages: 361-367
  • DOI: 10.1038/hr.2012.204
  • Peer Reviewed
• [Journal Article] Identification of the Stages of Diabetic Nephropathy at Which Angiotensin II Receptor Blockers Most Effectively Suppress Albuminuria (2013)
  • Author(s): Ogawa S, Matsushima M, Mori T, Okamura M, Senda M, Sakamoto T, Nako K, Ito S
  • Journal Title: Am J Hypertens Volume: 26(9) Issue: 9 Pages: 1064-1069
  • DOI: 10.1093/ajh/hpt085
  • Peer Reviewed
• [Journal Article] Beneficial Role of Tolvaptan in the Control of Body Fluids Without Reductions in Residual Renal Function in Patients Undergoing Peritoneal Dialysis. (2013)
  • Author(s): Takefumi Mori, Ikuko Oba, Kenji Koizumi, Mayumi Kodama, Miwako Shimanuki, Mizuho Tanno, Makiko Chida, Mai Saito, Hideyasu Kiyomoto, Mariko Miyazaki, Susumu Ogawa, Hiroshi Sato, Sadayoshi Ito
  • Journal Title: Advances in Peritoneal Dialysis Volume: 29 Pages: 33-37
  • Peer Reviewed
• [Journal Article] Icodextrin-Based Continuous Ambulatory Peritoneal Dialysis Therapy Effectively Reduces Left Ventricular Mass Index and Protects Cardiac Function in Patients with End-Stage Renal Disease. (2013)
  • Author(s): Ikuko Oba, Michiya Shinozaki, Kenji Harada, Takefumi Mori, Hidetoshi Kanai
  • Journal Title: Advances in Peritoneal Dialysis Volume: 29 Pages: 14-18
  • Peer Reviewed
• [Journal Article] Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. (2013)
  • Author(s): Zhu WJ, Nakayama M, Mori T, Hao K, Terawaki H, Katoh J, Kabayama S, Ito S
  • Journal Title: Med Gas Res Volume: 3(1) Issue: 1 Pages: 26-26
  • DOI: 10.1186/2045-9912-3-26
  • Peer Reviewed
• [Journal Article] 血管構造から見る脳心腎連関 (2013)
  • Author(s): 大崎雄介、森建文、伊藤貞嘉
  • Journal Title: BIO Clinica Volume: 28 (8) Pages: 18-22
• [Journal Article] RASと腎酸化ストレス (2013)
  • Author(s): 大崎雄介、森建文、伊藤貞嘉
  • Journal Title: Angiotensin Research Volume: 10(4) Pages: 50-55
• [Presentation] Role of long-term treatment of tolvaptan on left ventricular mass index in patients undergoing peritoneal dialysis. (2016)
  • Author(s): Kenji Koizumi, Takefumi Mori, Yusuke Ohsaki, Ikuko Ohba, Shinichi Sato, Satoshi Shimada, Eri Naganuma, Naho Kurasawa, Mihoko Tsuchikawa, Sadayoshi Ito.
  • Organizer: APCM-ISPD 2015
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] Association between clinical parameters and upper arm circumference of the patients undergoing peritoneal dialysis. (2016)
  • Author(s): Mihoko Tuchikawa, Takefumi Mori, Makiko Chida, Naho Kurasawa, Ikuko Yabana, Kenji Koizumi, Shinichi Sato, Satoshi Shimada, Eri Naganuma, Sadayoshi Ito
  • Organizer: APCM-ISPD 2015
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] Physiological Evaluation of Renal Congestion to the Worsening Renal Function. (2016)
  • Author(s): Takefumi Mori, Yusuke Ohsaki, Anyi Wang, Yoshimi Yoneki, Chika Takahashi, Sadayoshi Ito
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2016-03-18
• [Presentation] うっ血による腎機能低下機序に関する生理学的検討 (2015)
  • Author(s): 大崎雄介、森 建文、王 安邑、高橋知香、伊藤貞嘉
  • Organizer: 第6回腎不全研究会
  • Place of Presentation: 全社協・灘尾ホール(東京)
  • Year and Date: 2015-12-12
• [Presentation] 腹膜透析における酸性オルガネラによる新規腹膜線維化機序の解明 (2015)
  • Author(s): 矢花郁子、森 建文、高橋知香、大崎雄介、佐藤恵美子、廣瀬卓男、Nguyen Geneviève、Piedagnel Rémi、Ronco Pierre M、伊藤貞嘉
  • Organizer: 第6回腎不全研究会
  • Place of Presentation: 全社協・灘尾ホール(東京)
  • Year and Date: 2015-12-12
• [Presentation] 腹膜中皮細胞障害における酸性オルガネラの意義と(プロ) レニン受容体 (2015)
  • Author(s): 矢花郁子、森建文、高橋知香、伊藤貞嘉
  • Organizer: 第21回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2015-11-28
• [Presentation] ブドウ糖およびGDPsはラット腹膜中皮細胞でミトコンドリア由来の活性酸素（ROS）を生じる (2015)
  • Author(s): 島田佐登志、森建文、大崎雄介、伊藤貞嘉
  • Organizer: 第21回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2015-11-28
• [Presentation] 腹膜中皮細胞におけるNrf2標的遺伝子活性化の効果 (2015)
  • Author(s): 矢花郁子、森建文、高橋知香、大崎雄介、佐藤恵美子、伊藤貞嘉
  • Organizer: 第21回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2015-11-28
• [Presentation] ポジトロン断層法を利用した残腎機能の評価 (2015)
  • Author(s): 大崎雄介、森建文、田代学、志田原美保、小泉賢治、矢花郁子、岩田錬、宮澤英充、伊藤貞嘉
  • Organizer: 第21回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2015-11-28
• [Presentation] ブドウ糖分解産物により上皮間葉形質転換(EMT）の誘導された腹膜中皮への細胞移植の可能性の検討 (2015)
  • Author(s): 高橋知香、森建文、大崎雄介、矢花郁子、伊藤貞嘉
  • Organizer: 第21回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2015-11-28
• [Presentation] QOLを意識した体液調節と腹膜透析 (2015)
  • Author(s): 森建文
  • Organizer: 第21回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2015-11-28
  • Invited
• [Presentation] 食塩負荷による腎尿細管酸化ストレス産生の増大と血圧上昇メカニズム (2015)
  • Author(s): 大崎雄介、森建文、芦毅、長澤将、Allen W. Cowley, Jr.、伊藤貞嘉
  • Organizer: 日本栄養・食糧学会東北支部(第49回大会) 北海道支部(第45回大会) 合同支部大会
  • Place of Presentation: 東北大学農学部(仙台)
  • Year and Date: 2015-10-24
  • Invited
• [Presentation] PLASMA FREE AMINO ACIDS IN PATIENTS UNDERGOING PERITONEAL DIALYSIS. (2015)
  • Author(s): Naho Kurasawa, Takefumi Mori, Kenji Koizumi, Shinichi Sato, Ikuko Yabana, Satoshi Shimada, Yusuke Ohsaki, Emiko Sato, Eri Naganuma, Mihoko Tuchikawa, Sadayoshi Ito
  • Organizer: EURO PD 2015
  • Place of Presentation: Krakow, Poland
  • Year and Date: 2015-10-02
  • Int'l Joint Research
• [Presentation] ANGIOTENSIN INDEPENDENT ROLE OF (PRO)RENIN RECEPTOR IN HUMAN PERITONEAL MESOTHELIAL CELLS. (2015)
  • Author(s): Ikuko Yabana, Takefumi Mori, Chika Takahashi, Yusuke Ohsaki, Emiko Sato, Takuo Hirose, Geneviève Nguyen, Rémi Piedagnel, Pierre Ronco, Sadayoshi Ito
  • Organizer: EURO PD 2015
  • Place of Presentation: Krakow, Poland
  • Year and Date: 2015-10-02
  • Int'l Joint Research
• [Presentation] The effects of V2 receptor antagonist treatment on the renal medullary circulation and urinary sodium excretion in rat. (2015)
  • Author(s): Yusuke Ohsaki, Takefumi Mori, Kento Akao, Yoshimi Nakamichi, Chika Takahashi1, Sadayoshi Ito.
  • Organizer: Hypertension 2015 Scientific Sessions
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] ブドウ糖分解産物による腹膜傷害と腹膜中皮細胞移植の検討 (2015)
  • Author(s): 高橋知香，大崎雄介，森建文，大場郁子，伊藤貞嘉
  • Organizer: 第60回日本透析医学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2015-06-26
• [Presentation] 腹膜透析における(プロ)レニン受容体の動態と意義 (2015)
  • Author(s): 矢花郁子、森建文、高橋知香、佐藤恵美子、大崎雄介、鳴海かほり、伊藤貞嘉
  • Organizer: 第58回日本腎臓学会学術集会
  • Place of Presentation: 名古屋国際会議所(名古屋)
  • Year and Date: 2015-06-07
• [Presentation] ヒト免疫細胞に発現する(プロ)レニン受容体の機能検討 (2015)
  • Author(s): 鳴海かほり、廣瀬卓男、佐藤恵美子、佐藤博、森建文、伊藤貞嘉
  • Organizer: 第58回日本腎臓学会学術集会
  • Place of Presentation: 名古屋国際会議所(名古屋)
  • Year and Date: 2015-06-07
• [Presentation] ラットを用いた腎血行動態ならびにナトリウム排泄にV2受容体拮抗薬が及ぼす影響の検討 (2015)
  • Author(s): 大崎雄介、森建文、赤尾研人、中道淑美、高橋知香、伊藤貞嘉
  • Organizer: 第58回日本腎臓学会学術集会
  • Place of Presentation: 名古屋国際会議所(名古屋)
  • Year and Date: 2015-06-07
• [Presentation] ラットにおけるV2 受容体拮抗薬がナトリウム排泄に及ぼす影響の解析 (2015)
  • Author(s): 大崎雄介、森建文、赤尾研人、中道淑美、高橋知香、伊藤貞嘉
  • Organizer: 第5回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2015-03-21
• [Presentation] Glucose and Insulin Response to Peritoneal Dialysis Fluid in Diabetic and Non-diabetic Peritoneal Dialysis Patients (2015)
  • Author(s): Takefumi Mori, Makiko Chida, Ikuko Oba, Kenji Koizumi, Shinichi Sato, Eri Naganuma, Naho Kurasawa, Sadayoshi Ito.
  • Organizer: 35th Annual Dialysis Conference
  • Place of Presentation: Louisiana, NO, USA
  • Year and Date: 2015-02-02
• [Presentation] Association Between Home Blood Pressure and Body Composition by Bio-impedance Monitoring in Patients Undergoing Peritoneal Dialysis. (2015)
  • Author(s): Naho Kurasawa, Takefumi Mori, Eri Naganuma, Emiko Sato, Ikuko Oba, Kenji Koizumi, Shinichi Sato, Sadayoshi Ito.
  • Organizer: 35th Annual Dialysis Conference
  • Place of Presentation: Louisiana, NO, USA
  • Year and Date: 2015-02-02
• [Presentation] The Effects of Sodium Glucose Transporter Type 2 (SGLT2) Inhibitions on the Renal Medullary Circulation. (2014)
  • Author(s): Yusuke Ohsaki, Takefumi Mori, Kento Akao, Yoshimi Nakamichi, Chika Takahashi, Sadayoshi Ito.
  • Organizer: Kidney week 2014
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2014-11-14
• [Presentation] CKDにおける臓器連関と体液調節機序 (2014)
  • Author(s): 森 建文、大場 郁子、小泉 賢治、大崎 雄介、伊藤 貞嘉
  • Organizer: 第44回日本腎臓学会東部学術大会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2014-10-24
  • Invited
• [Presentation] V2受容体拮抗薬が腎血行動態に及ぼす影響の解析 (2014)
  • Author(s): 大崎雄介、森建文、赤尾研人、中道淑美、高橋知香、王安邑、伊藤貞嘉
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2014-10-17
• [Presentation] 心不全を伴う腹膜透析におけるV2受容体拮抗薬による残腎機能を保持した体液調整と左心室重量係数に対する効果 (2014)
  • Author(s): 小泉賢治、森建文、大場郁子、伊藤貞嘉
  • Organizer: 第20回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 山形国際ホテル(山形)
  • Year and Date: 2014-09-06
• [Presentation] 二次性高血圧の鑑別 (2014)
  • Author(s): 森 建文
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2014-07-06
  • Invited
• [Presentation] 慢性腎臓病における脳腎連関のメカニズム (2014)
  • Author(s): 森 建文
  • Organizer: 第59回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2014-06-13
  • Invited
• [Presentation] Solubleform of (pro)renin receptor is excreted from mesothelial cells to peritoneal dialysis effluent of peritoneal dialysis patients. (2014)
  • Author(s): I. Oba, T. Mori, C. Takahashi, Y. Ohsaki, E. Sato, K. Koizumi, M. Furusho, M. Chida, E. Naganuma and S. Ito.
  • Organizer: Experimental Biology 2014 (EB2014)
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-04-30
• [Presentation] Overexpression of glyoxalase 1 attenuates methylglyoxal-induced peritoneal injury with suppression of epithelial mesenchymal transition pathway and neovascularization in Wistar rats. (2013)
  • Author(s): Ikuko Oba, Takefumi Mori, Yusuke Ohsaki, Emiko Sato, Yoshimi Nakamichi, Toshio Miyata, and Sadayoshi Ito
  • Organizer: EB2013
  • Place of Presentation: Boston, MA, US
• [Presentation] The effects of low energy extracorporeal shock wave (SW) for renal ischemia reperfusion injury in rats. (2013)
  • Author(s): Mai Yoshida, Takashi Nakamichi, Takefumi Mori, Kenta Ito, Hiroaki Shimokawa, Sadayoshi Ito
  • Organizer: World congress of Nephrology 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] Specific role of carbonyl stress on peritoneal neovascularization and function in Wistar rats. (2013)
  • Author(s): Ikuko Oba, Takefumi Mori, Yusuke Ohsaki, Emiko Sato, Yoshimi Yoneki, Toshio Miyata, Sadayoshi Ito
  • Organizer: World congress of Nephrology 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] Functional (pro)renin receptor in human lymphocytes and monocytes. (2013)
  • Author(s): Kaori Narumi, Takuo Hirose, Emiko Sato, Takefumi Mori, Yusuke Ohsaki, Kiyomi Kisu, Mayuko Ishikawa, Tomonori Ishii, Hiroshi Sato, Sadayoshi Ito
  • Organizer: World congress of Nephrology 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] Urinary angiotensinogen and carbonyl compounds excretion associate with blood pressure in community health checkup – Kawasaki study. (2013)
  • Author(s): Wan An Yi, Emiko Sato, Takefumi mori, Yoshimi Nakamichi, Ikuko Ooba, Mai Yoshida, Takashi Nakamichi, Takeshi Fukushi, Sadayoshi Ito
  • Organizer: World congress of Nephrology 2013
  • Place of Presentation: Hong Kong, China
• [Presentation] Low energy extracorporenal shock wave (SW) ameliorates renal tubular injury in a rodent acute kidney injury (AKI) model. (2013)
  • Author(s): Mai Yoshida, Takashi Nakamichi, Takefumi Mori, Kenta Ito, Hiroaki Shimokawa, Sadayoshi Ito
  • Organizer: Kidney week 2013
  • Place of Presentation: Atlanta, GA, US
• [Presentation] V2 receptor antagonist tolvaptan ameliorates left ventricular mass index (LVMI) and urinary output without reduction in residual renal function in patients on peritoneal dialysis (PD). (2013)
  • Author(s): Kenji Koizumi, Takefumi Mori, Ikuko Oba, Sadayoshi Ito
  • Organizer: Kidney week 2013
  • Place of Presentation: Atlanta, GA, US
• [Presentation] 地域健康診断における尿中アンジオテンシノージェンと血圧の関連～Kawasaki Study～ (2013)
  • Author(s): 佐藤恵美子、森建文、中道淑美、大場郁子、吉田舞、中道崇、佐藤博、伊藤貞嘉
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] V2受容体拮抗薬の魅力～新たな体液調節メカニズムと内分泌医の役割～ (2013)
  • Author(s): 森建文
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] ヒトリンパ球および単球に存在する(プロ)レニン受容体の機能について (2013)
  • Author(s): 鳴海かほり、廣瀬卓男、森建文、佐藤恵美子、石井智徳、伊藤貞嘉
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 体外衝撃波はラット虚血腎の尿細管障害を改善する (2013)
  • Author(s): 吉田舞、中道崇、森建文、伊藤健太、下川宏明、伊藤貞嘉
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] 心腎不全におけるV2 受容体拮抗薬の意義 (2013)
  • Author(s): 森建文
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] 腹膜透析における上皮間葉形質転換を介した腹膜傷害機序の解明 (2013)
  • Author(s): 大場郁子、森 建文、大崎雄介、佐藤恵美子、中道淑美、赤尾研人、宮田敏男、伊藤貞嘉
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] 腹膜透析導入期患者のたんぱく制限と生体インピーダンス法を用いた栄養評価 (2013)
  • Author(s): 千田真貴子、丹野瑞穂、森建文、大場郁子、島貫美和子、小泉賢治、大崎雄介、伊藤貞嘉
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] 体重8Kgの乳児におけるPEとCHDF同時併用の経験 (2013)
  • Author(s): 佐々木俊一、小松亜紀、山本多恵、菅原克幸、村田弥栄子、菊池昭二、宮崎真理子、森建文
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] 透析患者の栄養評価と適正管理におけるインピーダンス法の有用性と問題点 (2013)
  • Author(s): 山本多恵、宮崎真理子、村田弥栄子、櫛引信子、立花佐友里、小松亜紀、佐々木俊一、菅原克幸、丹野瑞穂、森建文、佐藤博、伊藤貞嘉
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] 強皮症腎クリーゼの5例 (2013)
  • Author(s): 村田弥栄子、山本多恵、中山恵輔、中道崇、城田祐子、藤井博司、石井智徳、佐藤博、伊藤貞嘉、森建文、宮崎真理子
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] 腹膜透析排液における（プロ）レニン受容体の検討 (2013)
  • Author(s): 大場郁子、森建文、大崎雄介、鳴海かほり 、佐藤恵美子、小泉賢治、丹野瑞穂、島貫美和子、千田真貴子、堀内孝、伊藤貞嘉
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] V2受容体拮抗薬による腹膜透析患者の体液管理と残腎機能維持 (2013)
  • Author(s): 森建文、大場郁子、小泉賢治、丹野瑞穂、島貫美和子、千田真貴子、大崎雄介、伊藤貞嘉
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] 腹膜透析におけるカルボニルストレス抑制による腹膜保持メカニズムの解明 (2013)
  • Author(s): 大場郁子，森建文, 大崎雄介，佐藤恵美子, 中道淑美, 福士武, 宮田敏男, 伊藤貞嘉
  • Organizer: 第13回日本抗加齢医学会総会
  • Place of Presentation: 横浜
• [Presentation] 末期腎不全患者における残腎機能に対するV2受容体拮抗薬の役割 (2013)
  • Author(s): 森建文、大場郁子、小泉賢治、丹野瑞穂、児玉真由美、千田真貴子、大崎雄介、伊藤貞嘉
  • Organizer: 第13回日本抗加齢医学会総会
  • Place of Presentation: 横浜
• [Presentation] 糖尿病合併腹膜透析患者の持続血糖測定システムを用いた血糖変動の症例報告 (2013)
  • Author(s): 千田真貴子、森建文、大場郁子、丹野瑞穂、小泉賢治、古庄正英、児玉真由美、新沼美喜、伊藤貞嘉
  • Organizer: 第19回腹膜透析学会
  • Place of Presentation: 大阪
• [Presentation] 当科における腹膜透析患者の血清アルブミン値に影響を及ぼす因子 (2013)
  • Author(s): 丹野瑞穂、森建文、古庄正英、千田真貴子、小泉賢治、大場郁子、児玉真由美、新沼美喜、伊藤貞嘉
  • Organizer: 第19回腹膜透析学会
  • Place of Presentation: 大阪
• [Presentation] 腹膜透析関連感染症の現状から見る課題~2年間の診療評価~ (2013)
  • Author(s): 児玉真由美、森建文、大場郁子、小泉賢治、古庄正英、丹野瑞穂、千田真貴子、新沼美喜、伊藤貞嘉
  • Organizer: 第19回腹膜透析学会
  • Place of Presentation: 大阪
• [Presentation] 当院において示指矯正法手術を行った腹膜透析カテーテル閉塞症例の検討 (2013)
  • Author(s): 森建文、大場郁子、小泉賢治、古庄正英、丹野瑞穂、児玉真由美、千田真貴子、新沼美喜、大崎雄介、宮崎真理子、佐藤博、伊藤貞嘉
  • Organizer: 第43回日本腎臓学会東部学術大会
  • Place of Presentation: 東京
• [Presentation] 横隔膜交通症に対して自己血胸膜癒着術後に再発し保守的に経過をみている重症心不全の一例 (2013)
  • Author(s): 小泉賢治、森建文、大場郁子、古庄正英、丹野瑞穂、千田真貴子、児玉真由美、新沼美喜、大崎雄介、宮崎真理子、佐藤博、伊藤貞嘉
  • Organizer: 第43回日本腎臓学会東部学術大会
  • Place of Presentation: 東京
• [Presentation] 腹膜透析排液における（プロ）レニン受容体の検討 (2013)
  • Author(s): 大場郁子、森建文、高橋知香、大崎雄介、鳴海かほり、佐藤恵美子、千田真貴子、 小泉賢治、古庄正英、丹野瑞穂、永沼絵理、伊藤貞嘉
  • Organizer: 第4回腎不全研究会
  • Place of Presentation: 東京