| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
|---|
| Outline of Final Research Achievements |
The effects on the reactive oxygen species production of physiological stimuli were assessed in renal medullary thick ascending limb of loop of Henle (mTAL) in rats. Angiotensin II stimulation increased the intracellular ROS concentration through mitochondrial ROS production in mTAL. High concentration of glucose stimulated the mitochondrial ROS production via the glucose degradation products. Hypoxia also increased mitochondrial ROS production. The administration of mitoTEMPO, which is scavenger of mitochondrial ROS, attenuated the reduction of renal medullary blood flow and oxygen concentration induced by ischemia/reperfusion.
|
