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Detecting genetic component of schizophrenia

Research Project

Project/Area Number 25293253
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionFujita Health University

Principal Investigator

Iwata Nakao  藤田保健衛生大学, 医学部, 教授 (60312112)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Keywords遺伝学 / 精神科遺伝学
Outline of Final Research Achievements

A number of genome-wide association studies (GWASs) for schizophrenia have conducted, and now detected multiple susceptibility genes. However, as such locus cannot fully explain the heritability (i.e. missing heritability), rare variants may be the key factor to detect the whole range of the schizophrenia risk. In this study, we conducted a GWAS (for the common variants: SNP) and a target resequencing (for previously implicated loci) in the Japanese population, to detect the susceptibility genes for schizophrenia.
Approximately 5,000 subjects were genotyped, however, we could not find any significant association in SNP nor SNVs with schizophrenia.
Specifically, to examine the existence of the genetic risk within our samples, we conducted a polygenic component analysis: we did find significant enrichment of the risk alleles in our cases, implying accumulative genetic risk exists. Further sample size will be required to identify individual susceptibility SNP for schizophrenia.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results)

  • [Int'l Joint Research] Psychiatric GWAS Consortium(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population2016

    • Author(s)
      Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, Kawase K, Hashimoto S, Yamamori H, Yasuda Y, Fujimoto M et al
    • Journal Title

      Biol Psychiatry

      Volume: in press Issue: 8 Pages: 636-642

    • DOI

      10.1016/j.biopsych.2015.12.006

    • NAID

      120007129309

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide environment interaction between depressive state and stressful life events.2016

    • Author(s)
      Ikeda M, Shimasaki A, Takahashi A, Kondo K, Saito T, Kawase K, Esaki K, Otsuka Y, Mano K, Kubo M, Iwata N.
    • Journal Title

      J Clin Psychiatry

      Volume: 77(1) Issue: 01 Pages: e29-e30

    • DOI

      10.4088/jcp.15l10127

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic overlap between antipsychotic response and susceptibility to schizophrenia2015

    • Author(s)
      Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N.
    • Journal Title

      Journal of Clinical Psychopharmacology

      Volume: 35(1) Issue: 1 Pages: 85-88

    • DOI

      10.1097/jcp.0000000000000268

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants2015

    • Author(s)
      Hatano M, Ikeda M, Kondo K, Saito T, Shimasaki A, Esaki K, Umene-Nakano W, Yoshimura R, Nakamura J, Ozaki N, Iwata N
    • Journal Title

      J Hum Genet

      Volume: in press Issue: 6 Pages: 343-344

    • DOI

      10.1038/jhg.2015.21

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Replication and cross-phenotype study based upon schizophrenia GWASs data in the Japanese population: Support for association of MHC region with psychosis2014

    • Author(s)
      Saito T, Kondo K, Iwayama Y, Shimasaki A, Aleksic B, Yamada K, Toyota T, Hattori E, Esaki K, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 165 Issue: 5 Pages: 421

    • DOI

      10.1002/ajmg.b.32246

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population2014

    • Author(s)
      Kajio Y, Kondo K, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N.
    • Journal Title

      J Hum Genet

      Volume: 59 Issue: 1 Pages: 54

    • DOI

      10.1038/jhg.2013.116

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder. Nat Commun2013

    • Author(s)
      Lencz T, Guha S, Liu C, Rosenfeld J, Mukherjee S, Derosse P, John M, Cheng L, Zhang C, Badner JA, Ikeda M, Iwata N, Cichon S, Rietschel M, Nothen MM, Cheng AT, Hodgkinson C, Yuan Q, Kane JM, Lee AT, Pisante A, Gregersen PK, Pe'er I, Malhotra AK, Goldman D and Darvasi A
    • Journal Title

      Nat Commun

      Volume: 4) Issue: 5 Pages: 2739-2739

    • DOI

      10.1016/j.biopsych.2013.05.040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study2013

    • Author(s)
      Kondo K, Ikeda M, Kajio Y, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e70964-e70964

    • DOI

      10.1371/journal.pone.0070964

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia2013

    • Author(s)
      池田 匡志 他
    • Journal Title

      Neuropsychopharmacology

      Volume: 38 Issue: 10 Pages: 1864-1870

    • DOI

      10.1038/npp.2013.94

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed

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Published: 2013-05-21   Modified: 2022-01-27  

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