| Project/Area Number |
25293302
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Okayama University |
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Principal Investigator |
Toyooka Shinichi 岡山大学, 医歯(薬)学総合研究科, 教授 (30397880)
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| Co-Investigator(Kenkyū-buntansha) |
SOH Junichi 岡山大学, 病院, 講師 (90559890)
MATSUDA Fumihiko 京都大学, 大学院医学研究科, 教授 (50212220)
YAMAMOTO Hiromasa 岡山大学, 病院, 助教 (40467733)
TSUKUDA Kazunori 岡山大学, 病院, 講師 (20346430)
ASANO Hiroaki 岡山大学, 病院, 助教 (70534775)
MIYOSHI Shinichiro 岡山大学, 大学院医歯薬学総合研究科, 教授 (00190827)
SHIEN Kazuhiko 岡山大学, 大学院医歯薬学総合研究科, 助教 (30708079)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 原発性肺癌 / 薬剤耐性 / 癌幹細胞 / 上皮成長因子受容体チロシンキナーゼ阻害剤 / 上皮間葉移行 / 上皮成長因子受容体チロシンキナーゼ阻害薬 |
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| Outline of Final Research Achievements |
In this study, we aimed to understand and overcome drug resistance to EGFR tyrosine kinase inhibitors (EGFR-TKI) for lung cancer. We established EGFR-TKI resistant lung cancer cell lines, and specified several resistant mechanisms to EGFR-TKI by using these cell lines. Among them, we identified that acquiring of stem-cell like characteristics led to EGFR-TKI resistance, and several novel drugs were still effective to EGFR-TKI resistant cells. It is important to select an appropriate drug to treat acquired EGFR-TKI resistant cells according to each resistant mechanism.
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