Investigation of brain tumor derived exosomes; the role in tumorigeneity and therapy
| Project/Area Number |
25293311
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO KOJI 九州大学, 大学病院, 講師 (70444784)
AMANO TOSHIYUKI 九州大学, 医学(系)研究科(研究院), 研究員 (70448413)
NAKAMIZO AKIRA 九州大学, 医学(系)研究科(研究院), 研究員 (80529800)
秦 暢宏 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, その他 (10596034)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | glioma / exosome / microRNA / 分子病理学 / バイオマーカー / 脳腫瘍 / グリオーマ / エクソソーム |
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| Outline of Final Research Achievements |
Depend on recent advances in molecular pathology of human glioma, more accurate analysis is required for novel therapies. We established more precise genetic analysis by HRM and more simple evaluation method based on gene expression. The correlation between the gene expression type and microRNA (miR-9, -10b) indicated the relevance of microRNA for the mesenchymal-proneural transition. Furthermore analysis of secretory microRNA has revealed the potential role of secretory microRNA (miR-127, -145, -31) for glioms invasion. In addition, based on the expression of serum (plasma) microRNA, we identified potential novel biomarkers (miR-4530, -4294, -4534) for glioma patients.
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Report
(4 results)
Research Products
(18 results)
