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Molecular analysis and target exploration underlying progression of urologic cancers associated with obesity

Research Project

Project/Area Number 25293332
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Urology
Research InstitutionAkita University

Principal Investigator

HABUCHI Tomonori  秋田大学, 医学(系)研究科(研究院), 教授 (00293861)

Co-Investigator(Kenkyū-buntansha) OHYAMA Chikara  弘前大学, 医学系研究科, 教授 (80282135)
YUASA Takeshi  公益財団法人がん研究会有明病院, 泌尿器科, 副部長 (00314162)
NANJO Hiroshi  秋田大学, 医学部, 准教授 (70250892)
NUMAKURA Kazuyuki  秋田大学, 医学系研究科, 助教 (90566415)
土谷 順彦  山形大学, 医学部, 教授 (70282176)
鶴田 大  秋田大学, 医学部, 助教 (90466590)
Co-Investigator(Renkei-kenkyūsha) SASAKI Takehiko  秋田大学, 医学系研究科, 教授 (50333365)
NAKANISHI Hiroki  秋田大学, 生体情報センター, 助教 (10466740)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords前立腺癌 / 腎細胞癌 / 高脂肪食 / 肥満 / palmitic acid / fatty acid synthase / MIC-1 / 腎癌 / パルミチン酸 / 脂肪酸合成酵素 / AMPK / PI3K / miRNA / イノシトールリン脂質 / Fatty acid symthetase / リン脂質
Outline of Final Research Achievements

It is strongly suggested that recent remarkable increase in the incidence of urologic cancers may be caused by high-calorie or high-fat diet. In this study, we attempted to delineate the molecular mechanisms underlying the progression associated with high-fat diet or obesity and to find molecular therapeutic and preventive targets, using multi-modal analytical methods, such as animal experiments, molecular cellular biology, molecular epidemiology, clinical materials and metabolomics.
As the results, we showed that palmitic acid, which is the most abundant fatty acids in the body, plays an important role in the progression of prostate cancer via macrophage inhibitory factor 1 (MIC-1), and MIC-1 is a promising target in the cancer treatment. Furthermore, we showed that fatty acid synthase (FASN), which is the important enzymes involved in the production of palmitic acid, plays a significant role in the progression of prostate cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 Other

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 1 results) Remarks (3 results)

  • [Journal Article] Diet-induced alteration of fatty acid synthase in prostate cancer progression2016

    • Author(s)
      Huang M, Koizumi A, Narita S, Inoue T, Tsuchiya N, Nakanishi H, Numakura K, Tsuruta H, Saito M, Satoh S, Nanjo H, Sasaki T, Habuchi T
    • Journal Title

      Oncogenesis

      Volume: 5 Issue: 2 Pages: e195-e195

    • DOI

      10.1038/oncsis.2015.42

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of 1 year of androgen deprivation therapy on lipid and glucose metabolism and fat accumulation in Japanese patients with prostate cancer.2016

    • Author(s)
      Mitsuzuka K, Kyan A, Sato T, Orikasa K, Miyazato M, Aoki H, Kakoi N, Narita S, Koie T, Namima T, Toyoda S, Fukushi Y, Habuchi T, Ohyama C, Arai Y; Tohoku Evidence-Based Medicine Study Group; Michinoku Urological Cancer Study Group.
    • Journal Title

      Prostate Cancer Prostatic Dis.

      Volume: 19 Issue: 1 Pages: 57-62

    • DOI

      10.1038/pcan.2015.50

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor.2015

    • Author(s)
      Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T
    • Journal Title

      Cancer Discovery

      Volume: in press Issue: 7 Pages: 730-9

    • DOI

      10.1158/2159-8290.cd-14-1329

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci2015

    • Author(s)
      Amin Al Olama A, Ingles SA, Habuchi T, et al. Kote-Jarai Z, Eeles RA, Easton DF
    • Journal Title

      Cancer Epidemiol Biomarkers Prev

      Volume: 24 Issue: 7 Pages: 1121-1129

    • DOI

      10.1158/1055-9965.epi-14-0317

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of functional genetic polymorphisms in the CYP19A1 gene on prostate cancer risk and survival2015

    • Author(s)
      Kanda S, Tsuchiya N, Narita S, et al.
    • Journal Title

      Int J Cancer

      Volume: 136 Issue: 1 Pages: 74-82

    • DOI

      10.1002/ijc.28952

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lymphovascular invasion is significantly associated with biochemical relapse after radical prostatectomy even in patients with pT2N0 negative resection margin2014

    • Author(s)
      Mitsuzuka K, Narita S, Koie T, Kaiho Y, Tsuchiya N, Yoneyama T, Kakoi N, Kawamura S, Tochigi T, Ohyama C, Habuchi T, Arai Y
    • Journal Title

      Prostate Cancer Prostatic Dis

      Volume: ePub Issue: 1 Pages: 25-30

    • DOI

      10.1038/pcan.2014.40

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum tri-and tetra-antennary N-glycan is a potential predictive biomarker for castration-resistant prostate cancer.2014

    • Author(s)
      Ishibashi Y, Tobisawa Y, Hatakeyama S, Ohashi T, Tanaka M, Narita S, Koie T, Habuchi T, Nishimura S, Ohyama C, Yoneyama T
    • Journal Title

      Prostate

      Volume: 74 Issue: 15 Pages: 1521-1529

    • DOI

      10.1002/pros.22869

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measurement of aberrant glycosylation of prostate specific antigen can improve specificity in early detection of prostate cancer.2014

    • Author(s)
      Yoneyama T, Ohyama C, Hatakeyama S, Narita S, Habuchi T, Koie T, Mori K, Hidari KI, Yamaguchi M, Suzuki T, Tobisawa Y
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 448 Issue: 4 Pages: 390-396

    • DOI

      10.1016/j.bbrc.2014.04.107

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reassessment of prognostic heterogeneity of pT3 renal pelvic urothelial carcinoma: analysis in terms of proposed pT3 subclassification systems.2014

    • Author(s)
      Park J, Habuchi T, Arai Y, Ohyama C, Inoue T, Hatakeyama S, Jeon SS, Kwon GY, Kwak C, Moon KC, Kim CS, Ahn H.
    • Journal Title

      J Urol.

      Volume: 192 Issue: 4 Pages: 1064-1071

    • DOI

      10.1016/j.juro.2014.04.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional mononucleotide repeat polymorphism in the promoter region of HGF is associated with risk and malignant aggressiveness of bladder cancer.2014

    • Author(s)
      Chiba S, Tsuchiya N, Horikawa Y, Narita S, Inoue T, Akihama S, Saito M, Numakura K, Tsuruta H, Huang M, Satoh S, Habuchi T
    • Journal Title

      Int J Oncol

      Volume: 44 Issue: 3 Pages: 678-84

    • DOI

      10.3892/ijo.2013.2221

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression2014

    • Author(s)
      Huang M, Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T.
    • Journal Title

      Endocr Relat Cancer

      Volume: 21 Issue: 1 Pages: 39-50

    • DOI

      10.1530/erc-13-0227

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum N-glycan alteration associated with renal cell carcinoma detected by high-throughput glycan analysis.2014

    • Author(s)
      Hatakeyama S, Amano M, Tobisawa Y, Yoneyama T, Tsuchiya N, Habuchi T, Nishimura SI, Ohyama C
    • Journal Title

      J Urol.

      Volume: 191 Issue: 3 Pages: 805-813

    • DOI

      10.1016/j.juro.2013.10.052

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct cancer-specific survival in metastatic prostate cancer patients classified by a panel of single nucleotide polymorphisms of cancer-associated genes.2013

    • Author(s)
      Tsuchiya N, Matsui S, Narita S, Kamba T, Mitsuzuka K, Hatakeyama S, Horikawa Y, Inoue T, Saito S, Ohyama C, Arai Y, Ogawa O, Habuchi T.
    • Journal Title

      Genes Cancer.

      Volume: 4 Issue: 1-2 Pages: 54-60

    • DOI

      10.1177/1947601913481354

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of body mass index on clinicopathological outcome and biochemical recurrence after radical prostatectomy2013

    • Author(s)
      Narita S, Mitsuzuka K, Yoneyama T, Tsuchiya N, Koie T, Kakoi N, Kawamura S, Kaiho Y, Ohyama C, Tochigi T, Yamaguchi T, Habuchi T, Arai Y
    • Journal Title

      Prostate Cancer Prostatic Dis

      Volume: 16 Issue: 3 Pages: 271-276

    • DOI

      10.1038/pcan.2013.16

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis2013

    • Author(s)
      Tsuchiya N
    • Journal Title

      BMC Cancer

      Volume: 13 Issue: 1 Pages: 150-150

    • DOI

      10.1186/1471-2407-13-150

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] MiR-130a modulates high-fat diet-induced prostate cancer progression through the activation of MET2016

    • Author(s)
      Taketoshi Nara, Shintaro Narita, Huang Mingguo, Toshiaki Yoshioka, Koichiro Takayama, Kazuyuki Numakura, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Shigeru Satoh, Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2016
    • Place of Presentation
      米国、カルフォルニア州、SanDiego
    • Year and Date
      2016-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diet induced alteration of fatty acid synthase is involved in prostate cancer progression2014

    • Author(s)
      Mingguo Huang, Shintaro Narita, Norihiko Tsuchiya, Takamitsu Inoue, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi
    • Organizer
      American Urological Association Annual Meeting 2014
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Measurement of Prostate Cancer-Associated Aberrant Glycosylation of Prostate Specific Antigen can improve diagnostic accuracy2014

    • Author(s)
      Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Shintaro Narita, Tomonori Habuchi, Takuya Koie, Chikara Ohyama
    • Organizer
      American Urological Association Annual Meeting 2014
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inverse relationship between insulin receptor expression and favorable outcomes in patients who underwent radical nephrectomy for renal cell carcinoma2014

    • Author(s)
      Makoto Takahashi, Takamitsu Inoue, Mingguo Huang, Mitsuru Saito, Hiroshi Tsuruta, Kazuyuki Numakura, Susumu Akihama, Shintaro Narita, Norihiko Tsuchiya, Tomonori Habuchi
    • Organizer
      American Urological Association Annual Meeting 2014
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of factors associated with improvement of metabolic disorders following laparoscopic adrenalectomy in patients with Cushing's syndrome2014

    • Author(s)
      Kazuyuki Numakura, Norihiko Tsuchiya, Hiroshi Tsuruta, Susumu Akihama, Mitsuru Saito, Takamitsu Inoue, Shintaro Narita, Mingguo Huang, Shigeru Satoh, Tomonori Habuchi
    • Organizer
      American Urological Association Annual Meeting 2014
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Measurement of Prostate Cancer-Associated Aberrant Glycosylation of Prostate Specific Antigen can improve diagnostic accuracy2014

    • Author(s)
      Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Shintaro Narita, Tomonori Habuchi, Takuya Koie, Chikara Ohyama
    • Organizer
      American Urological Association Annual Meeting 2014
    • Place of Presentation
      Orland, Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inverse relationship between insulin receptor expression and favorable outcomes in patients who underwent radical nephrectomy for renal cell carcinoma2014

    • Author(s)
      Makoto Takahashi, Takamitsu Inoue, Mingguo Huang, Mitsuru Saito, Hiroshi Tsuruta, Kazuyuki Numakura, Susumu Akihama, Shintaro Narita, Norihiko Tsuchiya, Tomonori Habuchi
    • Organizer
      American Urological Association Annual Meeting 2014
    • Place of Presentation
      Orland, Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diet induced alteration of fatty acid synthase is involved in prostate cancer progression2014

    • Author(s)
      Mingguo Huang, Shintaro Narita, Norihiko Tsuchiya, Takamitsu Inoue, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi
    • Organizer
      American Urological Association Annual Meeting 2014
    • Place of Presentation
      Orland, Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Candidate microRNAs involved in high-fat diet induced tumor progression in prostate cancer2013

    • Author(s)
      Taketoshi Nara; Shintaro Narita; Huang Mingguo; Toshiaki Yoshioka; Kazuyuki Numakura; Susumu Akihama; Mitsuru Saito; Takamitsu Inoue; Norihiko Tsuchiya; Shigeru Satoh; Tomonori Habuchi
    • Organizer
      American Urological Association Annual Meeting 2013
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Common Genetic Variants Based Risk Prediction Model for Prostate Cancer is Highly Reproducible in Japanese, and Compensates for Prostate Specific Antigen at Gray-zone2013

    • Author(s)
      Shusuke Akamatsu; Ryo Takata; Atsushi Takahashi; Michiaki Kubo; Christopher Haiman; Brien Henderson; Tomoaki Fujioka; Tomonori Habuchi; Yusuke Nakamura; Osamu Ogawa; Hidewaki Nakagawa
    • Organizer
      American Urological Association Annual Meeting 2013
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Aberrant glycosylation of N-glycan on Immunoglobulin closely relates survival of the patients with in renal cell carcinoma2013

    • Author(s)
      Hatakeyama; Yuki Tobisawa; Tohru Yoneyama; Yuichiro Suzuki; Hayato Yamamoto; Kazuyuki Mori; Takahiro Yoneyama; Yasuhiro Hashimoto; Takuya Koie; Norihiko Tsuchiya; Tomonori Habuchi; Maho Amano; Shin-Ichiro Nishimura; Chikara Ohyama
    • Organizer
      American Urological Association Annual Meeting 2013
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科 腎泌尿器科学講座 - 秋田大学医学部

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科 腎泌尿器科学

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 秋田大学大学院 腎泌尿器科学講座 - 秋田大学医学部

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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