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Identification of molecular characteristics in serous carcinoma of Mullerian origin

Research Project

Project/Area Number 25293338
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNiigata University

Principal Investigator

ENOMOTO Takayuki  新潟大学, 医歯学系, 教授 (90283754)

Co-Investigator(Kenkyū-buntansha) INOUE Iturou  国立遺伝学研究所, 総合遺伝研究系, 教授 (00192500)
NAKA Tetuji  国立研究開発法人医薬基盤, 健康・栄養研究所・医薬基盤研究所・免疫シグナルプロジェクト, 招へいプロジェクトリーダー (30303936)
YOSHINO Kiyoshi  大阪大学, 医学系研究科, 准教授 (90362730)
UEDA Yutaka  大阪大学, 医学系研究科, 助教 (10346215)
SEKINE Masayuki  新潟大学, 医歯学系, 准教授 (70345502)
ADACHI Sousuke  新潟大学, 医歯学総合病院, 助教 (50613147)
芹川 武大  新潟大学, 医歯学総合病院, 講師 (30361918)
吉田 邦彦  新潟大学, 医歯学総合病院, 特任助教 (20648589)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
KeywordsTranslational research / microarray / genome / cancer / proteome / トランスレーショナルリサ ーチ / マイクロアレイ / ゲノム / 癌 / プロテオーム / トランスレーショナルリサーチ
Outline of Final Research Achievements

Our aim is to clarify the similarity of molecular characteristics in both ovarian and uterine endometrial serous carcinoma. We performed protein expression profiling on 14 cases of serous carcinomas (7 ovarian and 7 endometrial) and 18 endometrioid carcinomas (9 ovarian and 9 endometrial) using iTRAQ. Hierarchical clustering showed the similarity of protein expression profiles between ovarian and endometrial serous carcinomas. Using 45 statistically highly expressed proteins in serous carcinomas, protein ontology analysis detected two enriched terms and proteins composing each term: IMP2 and MCM2. Immunohistochemical analyses confirmed the higher expression of IMP2 and MCM2 in ovarian and endometrial serous carcinomas The knockdown of either IMP2 or MCM2 by siRNA interference significantly decreased the proliferation rate of ovarian serous carcinoma cell line. We suggest that increased IMP2 and MCM2 expression may underlie some of the rapid serous carcinoma growth observed clinically.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (28 results)

All 2016 2015 2014 2013 Other

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 22 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas.2016

    • Author(s)
      Hiramatsu K, Yoshino K, Serada S, Yoshihara K, Hori Y, Fujimoto M, Matsuzaki S, Egawa-Takata T, Kobayashi E, Ueda Y, Morii E, Enomoto T, Naka T, Kimura T.
    • Journal Title

      Br J Cancer.

      Volume: 114(5) Issue: 5 Pages: 554-561

    • DOI

      10.1038/bjc.2016.27

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus.2016

    • Author(s)
      Nakaoka H, Gurumurthy A, Hayano T, Ahmadloo S, Omer WH, Yoshihara K, Yamamoto A, Kurose K, Enomoto T, Akira S, Hosomichi K,, Inoue I.
    • Journal Title

      PLoS Genet.

      Volume: 1 Issue: 4 Pages: 1-23

    • DOI

      10.1371/journal.pgen.1005893

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment and characterization of an in vitro model of ovarian cancer stem-like cells with an enhanced proliferative capacity2016

    • Author(s)
      Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi R, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K.
    • Journal Title

      Cancer Research

      Volume: 76 Issue: 1 Pages: 150

    • DOI

      10.1158/0008-5472.can-15-0361

    • URL

      https://localhost/en/publications/72ae941f-9bf1-4237-bcbc-0368f1b8b005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.2015

    • Author(s)
      Matsuo K, Hasegawa K, Yoshino K, Murakami R, Hisamatsu T, Stone RL, Previs RA, Hansen JM, Ikeda Y, Miyara A, Hiramatsu K, Enomoto T, Fujiwara K, Matsumura N, Konishi I, Roman LD, Gabra H, Fotopoulou C, Sood AK
    • Journal Title

      Eur J Cancer

      Volume: 51 Issue: 14 Pages: 1978-1988

    • DOI

      10.1016/j.ejca.2015.07.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion.2015

    • Author(s)
      Matsuo K, Yoshino K, Hasegawa K, Murakami R, Ikeda Y, Adachi S, Hiramatsu K, Yokoyama T, Nishimura M, Sheridan TB, Enomoto T, Fujiwara K, Matsumura N, Konishi I, Fotopoulou C, Roman LD, Sood AK.
    • Journal Title

      Gynecol Oncol.

      Volume: 136 Issue: 2 Pages: 198-204

    • DOI

      10.1016/j.ygyno.2014.12.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel kinase fusion transcripts found in endometrial cancer.2015

    • Author(s)
      Tamura R, Yoshihara K, Yamawaki K, Suda K, Ishiguro T, Adachi S, Okuda S, Inoue I, Verhaak RG, Enomoto T.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 18657-18657

    • DOI

      10.1038/srep18657

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CpG ODN potentiates the anti-tumor activity of anti-BST2 antibody.2015

    • Author(s)
      Hiramatsu, K., Serada, S., Kobiyama, K., Nakagawa, S., Morimoto, A., Matsuzaki, S., Ueda,Y., Fujimoto, M., Yoshino, K., Ishii, K., Enomoto, T., Kimura, T., Naka, T.
    • Journal Title

      Cancer Science

      Volume: 106(10) Issue: 10 Pages: 474-82

    • DOI

      10.1111/cas.12738

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of novel exonic mobile element insertions in epithelial ovarian cancers.2015

    • Author(s)
      Hayano,T., Yamada,S., Hosomichi,K., Nakaoka,H., Yoshihara,K., Adachi.S. Kashima,K., Tanaka, K and Enomoto,T.& Inoue,I.
    • Journal Title

      Human Genome Variation

      Volume: 2 Issue: 1 Pages: 15030-15030

    • DOI

      10.1038/hgv.2015.30

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma.2015

    • Author(s)
      Okamoto A, Sehouli J, Yanaihara N, Hirata Y, Braicu I, Kim BG, Takakura S, Saito M, Yanagida S, Takenaka M, Yamaguchi N, Morikawa A, Tanabe H, Yamada K, Yoshihara K, Enomoto T, Itamochi H, Kigawa J, Matsumura N, Konishi I, Aida S, Aoki Y, Ishii N, Ochiai K, Akiyama T, Urashima M.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: 1-13

    • DOI

      10.1371/journal.pone.0116977

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Japan’s failure to vaccinate girls against human papillomavirus2015

    • Author(s)
      Ueda , Y., Enomoto, T., Sekine ,M., Egawa-Takata, T., Morimoto, A., Kimura ,T.
    • Journal Title

      American Journal of Obstetrics and Gynecology

      Volume: 212(3) Issue: 3 Pages: 405-406

    • DOI

      10.1016/j.ajog.2014.11.037

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complex chromosomal rearrangements in couples affected by recurrent spontaneous abortion.2015

    • Author(s)
      Nonaka,T., Ooki,I., Enomoto,T., Takakuwa,K.
    • Journal Title

      nt J Gynaecol and Obstet

      Volume: 128(1) Issue: 1 Pages: 36-9

    • DOI

      10.1016/j.ijgo.2014.07.018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a Free-Coupon Program for Cervical Cancer Screening Among the Young: A Nationally Funded Program Conducted by a Local Government in Japan2015

    • Author(s)
      Ueda,Y., Sobue,T., Morimoto,A., Egawa-Takata,T., Hashizume,C., Kishida,H., Okamoto,S., Yoshino,K., FUjita, M., Enomoto,T., Tomine,Y., Fujiyoshi, J., Kimura,T.
    • Journal Title

      Journal of Epidemiology

      Volume: 25 Issue: 1 Pages: 50-56

    • DOI

      10.2188/jea.JE20140080

    • NAID

      130004694369

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Characterization of an Intact p53 Pathway Subtype in High-Grade Serous Ovarian Cancer2014

    • Author(s)
      Hayano,T., Yokota,Y., Hosomichi,K., Nakaoka,H., Yoshihara,K., Adachi,S., Kashima,K., Tsuda,H.,Moriya,T.,Tanaka,K., Enomoto,T., Inoue,I.
    • Journal Title

      PLoS One

      Volume: 9(12) Issue: 12 Pages: 114491-114491

    • DOI

      10.1371/journal.pone.0114491

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes and Prognostic Factors for Adenocarcinoma/Adenosquamous Carcinomas Treated with Radical Hysterectomy and Adjuvant Therapy.2014

    • Author(s)
      Yamaguchi,M., Yamagishi,Y., Nishikawa,N., Sekine,M., Serikawa,T., Kashima,K., Enomoto,T
    • Journal Title

      Open J Obstet Gynecology

      Volume: 4 Issue: 14 Pages: 909-915

    • DOI

      10.4236/ojog.2014.414128

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative Ultrasound- Guided Needle Biopsy of 63 Uterine Tumors Having High Signal Intensity Upon T2- Weighted Magnetic Resonance Imaging2014

    • Author(s)
      Tamura,R., Kashima,K., Asatani,M., Nishino,K., Nishikawa,N., Sekine,M., Serikawa,T., and Enomoto,T.
    • Journal Title

      Int J of Gynecological Cancer

      Volume: 24(6) Issue: 6 Pages: 1042-1047

    • DOI

      10.1097/igc.0000000000000189

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A2014

    • Author(s)
      Matsuzaki S, Enomoto T, Serada S, Yoshino K, Nagamori S, Morimoto A, Yokoyama T, Kim A, Kimura T, Ueda Y, Fujita M, Fujimoto M, Kanai Y, Kimura T, Naka T
    • Journal Title

      Int J Cancer

      Volume: 134 Issue: 8 Pages: 1796-1809

    • DOI

      10.1002/ijc.28526

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal molecular diagnosis of X-linked hydrocephalus via a silent C924T mutation in the L1CAM gene2014

    • Author(s)
      Serikawa T, Nishiyama K, Tohyama J, Tazawa R, Goto K, Kuriyama Y, Haino K, Kanemura Y, Yamasaki M, Nakata K, Takakuwa K, Enomoto T.
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: 54 Issue: 4 Pages: 243-245

    • DOI

      10.1111/cga.12069

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: a phase II trial.2013

    • Author(s)
      Miyatake T.
    • Journal Title

      Jounal of Cancer Research and Clinical Oncology

      Volume: 139 Issue: 3 Pages: 457-463

    • DOI

      10.1007/s00432-012-1348-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase II study of combination chemotherapy using docetaxel and irinotecan for TC-refractory or TC-resistant ovarian carcinomas (GOGO-OV2 study) and for primary clear or mucinous ovarian carcinomas (GOGO-OV3 Study)2013

    • Author(s)
      Ueda, Y. Miyatake, T. Nagamatsu, M. Yamasaki, M. Nishio, Y. Yoshino, K. Fujita, M. Tsutsui, T. Enomoto, T. Kimura, T.
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 170 Issue: 1 Pages: 259-263

    • DOI

      10.1016/j.ejogrb.2013.06.035

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma nlembrane proteonlics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer2013

    • Author(s)
      Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T, Naka T
    • Journal Title

      Int J Cancer

      Volume: 132(2) Issue: 2 Pages: 472-84

    • DOI

      10.1002/ijc.27679

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Taxane-sensitivity of ovarian carcinomas previously treated with paclitaxel and carboplatin2013

    • Author(s)
      Ueda, Y. Enomoto, T. Matsuzaki, S. Kobayashi, E. Toshihiro Kimura Yoshino, K. Fujita, M. Tsutsui, T. Kimura, T.
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 71 Issue: 6 Pages: 1411-1416

    • DOI

      10.1007/s00280-013-2138-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salvage chemotherapy for recurrent or persistent clear cell carcinoma of the ovary: a single-institution experience for a series of 20 patients2013

    • Author(s)
      Yoshino K, Enomoto T, Fujita M, Ueda Y, Kimura T, Kobayashi E, Tsutsui T, Kimura T
    • Journal Title

      Int J Clin Oncol

      Volume: 18 Issue: 1 Pages: 148-53

    • DOI

      10.1007/s10147-011-0357-5

    • NAID

      10031176248

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] A proteomic analysis demonstrates similar expression pattern between ovarian and endometrial high-grade serous carcinoma beyond an organ2015

    • Author(s)
      Kosuke Hiramatsu, Kiyoshi Yoshino, Satoshi Serada, Kosuke Yoshihara, Minoru Fujimoto, Yutaka Ueda, Eiichi Morii, Takayuki Enomoto, Tetsuji Naka, Tadashi Kimura
    • Organizer
      24th Asian and Oceanic Congress of Obstetrics and Gynaecology
    • Place of Presentation
      Borneo Convention Centre Kuching(Malaysia)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 卵巣および子宮体部のhigh- grade serous carcinoma の類似性の証明2015

    • Author(s)
      平松宏祐、榎本隆之、吉原弘祐、上田豊、吉野潔、森井英一、仲哲治、木村正
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 卵巣および子宮体部のhigh-grade serous carcinoma の類似性の証明2015

    • Author(s)
      平松宏祐、榎本隆之、吉原弘祐、上田豊、吉野潔、森井英一、仲哲治、木村正
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2015-04-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮がんワクチン

    • Author(s)
      榎本隆之
    • Organizer
      第30回日本臨床細胞学会北陸支部連合学術集会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Association between Endometriosis and Ovarian Cancer: A Review of Epidemiologic, Pathologic, Genetic, and Clinical Data2013

    • Author(s)
      Yokoyama, T. Yoshino, K. Ueda, Y. Enomoto, T
    • Total Pages
      33
    • Publisher
      Endometriosis: Risk Factors, Symptoms and Management
    • Related Report
      2013 Annual Research Report
  • [Book] Molecular Biology of Endometriosis2013

    • Author(s)
      Adachi,S. Enomoto, T
    • Total Pages
      5
    • Publisher
      Endometriosis: Risk Factors, Symptoms and Management Nova science publishers,Inc
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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