Identification of molecular characteristics in serous carcinoma of Mullerian origin
Project/Area Number |
25293338
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Niigata University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
INOUE Iturou 国立遺伝学研究所, 総合遺伝研究系, 教授 (00192500)
NAKA Tetuji 国立研究開発法人医薬基盤, 健康・栄養研究所・医薬基盤研究所・免疫シグナルプロジェクト, 招へいプロジェクトリーダー (30303936)
YOSHINO Kiyoshi 大阪大学, 医学系研究科, 准教授 (90362730)
UEDA Yutaka 大阪大学, 医学系研究科, 助教 (10346215)
SEKINE Masayuki 新潟大学, 医歯学系, 准教授 (70345502)
ADACHI Sousuke 新潟大学, 医歯学総合病院, 助教 (50613147)
芹川 武大 新潟大学, 医歯学総合病院, 講師 (30361918)
吉田 邦彦 新潟大学, 医歯学総合病院, 特任助教 (20648589)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
|
Keywords | Translational research / microarray / genome / cancer / proteome / トランスレーショナルリサ ーチ / マイクロアレイ / ゲノム / 癌 / プロテオーム / トランスレーショナルリサーチ |
Outline of Final Research Achievements |
Our aim is to clarify the similarity of molecular characteristics in both ovarian and uterine endometrial serous carcinoma. We performed protein expression profiling on 14 cases of serous carcinomas (7 ovarian and 7 endometrial) and 18 endometrioid carcinomas (9 ovarian and 9 endometrial) using iTRAQ. Hierarchical clustering showed the similarity of protein expression profiles between ovarian and endometrial serous carcinomas. Using 45 statistically highly expressed proteins in serous carcinomas, protein ontology analysis detected two enriched terms and proteins composing each term: IMP2 and MCM2. Immunohistochemical analyses confirmed the higher expression of IMP2 and MCM2 in ovarian and endometrial serous carcinomas The knockdown of either IMP2 or MCM2 by siRNA interference significantly decreased the proliferation rate of ovarian serous carcinoma cell line. We suggest that increased IMP2 and MCM2 expression may underlie some of the rapid serous carcinoma growth observed clinically.
|
Report
(4 results)
Research Products
(28 results)
-
[Journal Article] Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas.2016
Author(s)
Hiramatsu K, Yoshino K, Serada S, Yoshihara K, Hori Y, Fujimoto M, Matsuzaki S, Egawa-Takata T, Kobayashi E, Ueda Y, Morii E, Enomoto T, Naka T, Kimura T.
-
Journal Title
Br J Cancer.
Volume: 114(5)
Issue: 5
Pages: 554-561
DOI
Related Report
Peer Reviewed
-
[Journal Article] Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus.2016
Author(s)
Nakaoka H, Gurumurthy A, Hayano T, Ahmadloo S, Omer WH, Yoshihara K, Yamamoto A, Kurose K, Enomoto T, Akira S, Hosomichi K,, Inoue I.
-
Journal Title
PLoS Genet.
Volume: 1
Issue: 4
Pages: 1-23
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Establishment and characterization of an in vitro model of ovarian cancer stem-like cells with an enhanced proliferative capacity.2016
Author(s)
Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi R, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K.
-
Journal Title
Cancer Research
Volume: 76
Issue: 1
Pages: 150-160
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.2015
Author(s)
Matsuo K, Hasegawa K, Yoshino K, Murakami R, Hisamatsu T, Stone RL, Previs RA, Hansen JM, Ikeda Y, Miyara A, Hiramatsu K, Enomoto T, Fujiwara K, Matsumura N, Konishi I, Roman LD, Gabra H, Fotopoulou C, Sood AK
-
Journal Title
Eur J Cancer
Volume: 51
Issue: 14
Pages: 1978-1988
DOI
Related Report
Peer Reviewed
-
[Journal Article] Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion.2015
Author(s)
Matsuo K, Yoshino K, Hasegawa K, Murakami R, Ikeda Y, Adachi S, Hiramatsu K, Yokoyama T, Nishimura M, Sheridan TB, Enomoto T, Fujiwara K, Matsumura N, Konishi I, Fotopoulou C, Roman LD, Sood AK.
-
Journal Title
Gynecol Oncol.
Volume: 136
Issue: 2
Pages: 198-204
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] CpG ODN potentiates the anti-tumor activity of anti-BST2 antibody.2015
Author(s)
Hiramatsu, K., Serada, S., Kobiyama, K., Nakagawa, S., Morimoto, A., Matsuzaki, S., Ueda,Y., Fujimoto, M., Yoshino, K., Ishii, K., Enomoto, T., Kimura, T., Naka, T.
-
Journal Title
Cancer Science
Volume: 106(10)
Issue: 10
Pages: 474-82
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Identification of novel exonic mobile element insertions in epithelial ovarian cancers.2015
Author(s)
Hayano,T., Yamada,S., Hosomichi,K., Nakaoka,H., Yoshihara,K., Adachi.S. Kashima,K., Tanaka, K and Enomoto,T.& Inoue,I.
-
Journal Title
Human Genome Variation
Volume: 2
Issue: 1
Pages: 15030-15030
DOI
Related Report
Peer Reviewed
-
[Journal Article] Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma.2015
Author(s)
Okamoto A, Sehouli J, Yanaihara N, Hirata Y, Braicu I, Kim BG, Takakura S, Saito M, Yanagida S, Takenaka M, Yamaguchi N, Morikawa A, Tanabe H, Yamada K, Yoshihara K, Enomoto T, Itamochi H, Kigawa J, Matsumura N, Konishi I, Aida S, Aoki Y, Ishii N, Ochiai K, Akiyama T, Urashima M.
-
Journal Title
PLoS One
Volume: 10
Issue: 2
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Japan’s failure to vaccinate girls against human papillomavirus2015
Author(s)
Ueda , Y., Enomoto, T., Sekine ,M., Egawa-Takata, T., Morimoto, A., Kimura ,T.
-
Journal Title
American Journal of Obstetrics and Gynecology
Volume: 212(3)
Issue: 3
Pages: 405-406
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Evaluation of a Free-Coupon Program for Cervical Cancer Screening Among the Young: A Nationally Funded Program Conducted by a Local Government in Japan2015
Author(s)
Ueda,Y., Sobue,T., Morimoto,A., Egawa-Takata,T., Hashizume,C., Kishida,H., Okamoto,S., Yoshino,K., FUjita, M., Enomoto,T., Tomine,Y., Fujiyoshi, J., Kimura,T.
-
Journal Title
Journal of Epidemiology
Volume: 25
Issue: 1
Pages: 50-56
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed
-
[Journal Article] Molecular Characterization of an Intact p53 Pathway Subtype in High-Grade Serous Ovarian Cancer2014
Author(s)
Hayano,T., Yokota,Y., Hosomichi,K., Nakaoka,H., Yoshihara,K., Adachi,S., Kashima,K., Tsuda,H.,Moriya,T.,Tanaka,K., Enomoto,T., Inoue,I.
-
Journal Title
PLoS One
Volume: 9(12)
Issue: 12
Pages: 114491-114491
DOI
Related Report
Peer Reviewed
-
[Journal Article] Outcomes and Prognostic Factors for Adenocarcinoma/Adenosquamous Carcinomas Treated with Radical Hysterectomy and Adjuvant Therapy.2014
Author(s)
Yamaguchi,M., Yamagishi,Y., Nishikawa,N., Sekine,M., Serikawa,T., Kashima,K., Enomoto,T
-
Journal Title
Open J Obstet Gynecology
Volume: 4
Issue: 14
Pages: 909-915
DOI
Related Report
Peer Reviewed
-
[Journal Article] Preoperative Ultrasound- Guided Needle Biopsy of 63 Uterine Tumors Having High Signal Intensity Upon T2- Weighted Magnetic Resonance Imaging2014
Author(s)
Tamura,R., Kashima,K., Asatani,M., Nishino,K., Nishikawa,N., Sekine,M., Serikawa,T., and Enomoto,T.
-
Journal Title
Int J of Gynecological Cancer
Volume: 24(6)
Issue: 6
Pages: 1042-1047
DOI
Related Report
Peer Reviewed
-
[Journal Article] Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A2014
Author(s)
Matsuzaki S, Enomoto T, Serada S, Yoshino K, Nagamori S, Morimoto A, Yokoyama T, Kim A, Kimura T, Ueda Y, Fujita M, Fujimoto M, Kanai Y, Kimura T, Naka T
-
Journal Title
Int J Cancer
Volume: 134
Issue: 8
Pages: 1796-1809
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Prenatal molecular diagnosis of X-linked hydrocephalus via a silent C924T mutation in the L1CAM gene2014
Author(s)
Serikawa T, Nishiyama K, Tohyama J, Tazawa R, Goto K, Kuriyama Y, Haino K, Kanemura Y, Yamasaki M, Nakata K, Takakuwa K, Enomoto T.
-
Journal Title
Congenit Anom (Kyoto)
Volume: 54
Issue: 4
Pages: 243-245
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] A phase II study of combination chemotherapy using docetaxel and irinotecan for TC-refractory or TC-resistant ovarian carcinomas (GOGO-OV2 study) and for primary clear or mucinous ovarian carcinomas (GOGO-OV3 Study)2013
Author(s)
Ueda, Y. Miyatake, T. Nagamatsu, M. Yamasaki, M. Nishio, Y. Yoshino, K. Fujita, M. Tsutsui, T. Enomoto, T. Kimura, T.
-
Journal Title
Eur J Obstet Gynecol Reprod Biol
Volume: 170
Issue: 1
Pages: 259-263
DOI
Related Report
Peer Reviewed
-
[Journal Article] Plasma nlembrane proteonlics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer2013
Author(s)
Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T, Naka T
-
Journal Title
Int J Cancer
Volume: 132(2)
Issue: 2
Pages: 472-84
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] 子宮がんワクチン
Author(s)
榎本隆之
Organizer
第30回日本臨床細胞学会北陸支部連合学術集会
Place of Presentation
金沢市
Related Report
Invited
-
-