| Project/Area Number |
25293416
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUMITA Yoshinori 長崎大学, 医歯薬学総合研究科, 准教授 (50456654)
SHINOHARA Atsushi 松本歯科大学, 歯学部, 教授 (90196402)
渡辺 信和 東京大学, 医科学研究所, 准教授 (10334278)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 唾液腺 / 放射線障害 / 骨髄単核球細胞 / 骨髄間質細胞 / 臍帯由来間葉系幹細胞 / 再生医療 / 幹細胞 / 口腔乾燥症 / 細胞治療 |
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| Outline of Final Research Achievements |
Radiation for head and neck cancer induces salivary gland atrophy, which leads to xerostomia. Xerostomia affects various oral functions and causes masticatory dysfunction and swallowing problem. However, there is no treatment to regenerate damaged glands. In this study, we focused on cell-based regenerative medicine to explore the possibility to regenerate atrophic salivary gland and also its potent mechanisms. Not only bone marrow stromal cells but also monocytes from bone marrow aspirate and human umbilical cord-derived mesenchymal stem cells can induce recovery of saliva flow after radiation damage. From in vitro model study, it has been suggested that the molecules from transplanted cells induce the functional recovery of acinar cells, which may lead to the recovery of saliva flow from the damaged gland.
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