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Joint Cooperative Research for Endemic Diseases Control in Ghana

Research Project

Project/Area Number 25305008
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Parasitology (including sanitary zoology)
Research InstitutionOkayama University

Principal Investigator

KIM Hye-Sook  岡山大学, 医歯(薬)学総合研究科, 准教授 (70314664)

Co-Investigator(Kenkyū-buntansha) DOI Hiroyuki  岡山大学, 大学院医歯薬学総合研究科, 教授 (20452568)
KATO Nobuyuki  岡山大学, 大学院医歯薬学総合研究科, 教授 (40150883)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsマラリア / リーシュマニア症 / HCV / 遺伝子解析 / 創薬シーズ / 風土病 / 疫学 / リーシュマニア / 疫学調査
Outline of Final Research Achievements

The epidemiological study of Leishmaniasis was L. major only using lesion of several different parts of patients and major vector was S. Africana in the Volta region. In the genetic analysis of drug-resistant malaria, most of the patient samples collected after 2010 showed a drug-sensitive gene type and one of reason of the result was caused by Ghana government malaria treatment-polish was changed to Artemisinin-based combination therapy than other classical malaria drugs.To effective analysis of HCV patient in Ghana, the universal primer-set was determined in the 5'-untranslated region of HCV genome.
We found a new drug discovery seeds showing the ability to inhibit both of malaria and leishmaniasis using in Milletia Thonningii of Ghanaian natural products.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (25 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] ガーナ大学 野口研/ガーナ大学 理学部(ガーナ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Improvement of oral bioavailability of N-251, a novel antimalarial drug, by long-chain fatty acid-based self-microemulsifying drug delivery system2015

    • Author(s)
      Imada, C., Takahashi, T., Kuramoto, M., Masuda, K., Ogawara, K., Sato, A., Wataya, Y., Kim, H.-S. and Higaki, K
    • Journal Title

      Pharm. Res.,

      Volume: 32 (8) Pages: 2595-2608

    • DOI

      10.1007/s11095-015-1646-x

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 薬剤耐性マラリアに有望な新規抗マラリア薬開発の現況2015

    • Author(s)
      金 惠淑、片本 茜、佐藤 聡、綿矢有佑、土居弘幸
    • Journal Title

      岡山医学会雑誌

      Volume: 127 (12) Pages: 231-235

    • NAID

      130005116817

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum.2015

    • Author(s)
      Morita, M., Koyama, T., Sanai, H., Sato, K., hiramoto, A., Masuyama, A., Nojima, M., Wataya, Y. and Kim, H.-S
    • Journal Title

      Parasitol. Int.

      Volume: 64 Issue: 1 Pages: 113-117

    • DOI

      10.1016/j.parint.2014.10.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular dynamics and energetic perceptions of substrate recognition by thymidylate kinase2014

    • Author(s)
      Kandeel, M., Noguchia, Y., Oh-Hashic, K., Kim, H.-S. and Kitade, Y
    • Journal Title

      J. Thermal Analysis and Calorimetry

      Volume: 115 Issue: 3 Pages: 2089-2097

    • DOI

      10.1007/s10973-013-3319-5

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New preclinical antimalarial drugs potently inhibit hepatitis C virus genotype 1b RNA replication2013

    • Author(s)
      Ueda, Y., Takeda, M., Mori, K., Dansako, H., Wakita, T., Kim, H.-S., Sato, A., Wataya, Y., Ikeda, M. and Kato, N.
    • Journal Title

      PLosOne,

      Volume: 8 Pages: 1-11

    • NAID

      120005697275

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Applications of triphenylpyrylium salt-sensitized electron transfer photo-oxygenation reactions to the synthesis of benzo-fused 1,4-diaryl-2,3- dioxabicyclo[2.2.2]octanes as new antimalarial cyclic peroxides.2013

    • Author(s)
      Kamata, M., Hagiwara, J., Hokari,T., Suzuki,C., Fujino,R., Kobayashi,S., Kim,H.-S. and Wataya, Y
    • Journal Title

      Research on Chemical Intermediate

      Volume: 39 Pages: 127-137

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 経皮吸収型抗マラリア薬の開発研究2016

    • Author(s)
      槇田真千子,河本理沙、金 惠淑
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 経皮吸収型抗マラリア薬の開発研究2016

    • Author(s)
      金 惠淑、河本理沙、槇田真千子、綿矢有佑
    • Organizer
      第85回日本寄生虫学会大会
    • Place of Presentation
      宮崎市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 日本から発信する抗マラリア薬2016

    • Author(s)
      金 惠淑、綿矢有佑、河本理沙、槇田真千子、土居弘幸
    • Organizer
      医療展示会中央西日本メディカールイノベーション2016
    • Place of Presentation
      岡山市
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Current situation of antimalarial endoperoxides in Japan2015

    • Author(s)
      Hye-Sook Kim
    • Organizer
      Forum Cheju 17
    • Place of Presentation
      吹田市
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pharmacokinetic Study of Antimalarial-Endoperoxides2015

    • Author(s)
      Hye-Sook Kim, Risa Komoto, Makiko Makita, Yusuke Wataya, Yuji Kurosaki and Kazutaka Higaki
    • Organizer
      Forum Cheju 17
    • Place of Presentation
      吹田市
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本から発信する新しい抗マラリア薬2015

    • Author(s)
      金 惠淑
    • Organizer
      ライフサイエンスワールド2015(アカデミックフォーラム)
    • Place of Presentation
      東京都
    • Year and Date
      2015-05-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗マラリア候補・環状過酸化物の開発現況 (シンポジウム企画)2015

    • Author(s)
      金 惠淑
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      三鷹市
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Antimalarial Drug Development of Synthetic Endoperoxides as New Drug2014

    • Author(s)
      Hye-Sook Kim, Yuka Nakamura, Risa Komoto, Kaoru, Kanai, Akira Sato, Yuji Kuroaki, Kazutaka Higaki, Yusuke Wataya
    • Organizer
      大韓寄生虫学・熱帯医学会 第56回総会および学術大会
    • Place of Presentation
      釜山、大韓民国
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 難治性感染症制御に向けてー薬剤耐性マラリアに有望な新薬開発の現況ー2014

    • Author(s)
      ○ 金惠淑、中村由香、河本理沙、金井 薫、佐藤 聡、綿矢有佑、檜垣和孝、黒崎勇二
    • Organizer
      第70回日本寄生虫学会西日本支部大会
    • Place of Presentation
      神戸市
    • Year and Date
      2014-10-18 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Improvement of Oral Absorption Behavior of Antimalarial Candidate of N-251 by Self Micro-emulsifying Drug Delivery System (SMEDDS)2014

    • Author(s)
      Hye-Sook Kim, Chikako, Imada, Makoto Kuramoto, Ken-Ichi Ogawara, Akira Sato, Yusuke Wataya, Kazutaka Higaki
    • Organizer
      BA/BE 2014 Conference
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-10-06 – 2014-10-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Antimalarial Drug Development of Synthetic N-251 Compound as New Drug2014

    • Author(s)
      Hye-Sook Kim, Yuka Nakamura, Risa Komoto, Kaoru, Sato, Yusuke Wataya, Daniel Adjei Boakye
    • Organizer
      13th INTERNATIONAL CONGRESS OF PARASITOLOGY 2014
    • Place of Presentation
      MXico City, Mexico
    • Year and Date
      2014-08-10 – 2014-08-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非経口型抗マラリア薬の開発研究2014

    • Author(s)
      金 惠淑、中村由香、河本理沙、片本茜、佐藤聡、檜垣和孝、黒崎勇二、綿矢有佑
    • Organizer
      日本薬学会134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非経口型抗マラリア薬の開発現況2014

    • Author(s)
      金 惠淑、中村由香、河本理沙、片本茜、佐藤聡、綿矢有佑、檜垣和孝、黒崎勇二
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      松山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 経皮吸収型抗マラリア薬の開発研究2013

    • Author(s)
      中村 由香、片本 茜、佐藤 聡、檜垣 和孝、綿矢 有佑、金 惠淑
    • Organizer
      第69回日本寄生虫学会西日本支部大会
    • Place of Presentation
      香川
    • Related Report
      2013 Annual Research Report
  • [Presentation] New Candidates as Anti-Malarial Drugs2013

    • Author(s)
      Hye-Sook Kim, Masayuki Morita, Akane Katamoto, Hiroki Watanabe, Akira Sato, Kazutaka Higaki, and Yusuke Wataya
    • Organizer
      FORUM CHEJU 16
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗マラリア剤2015

    • Inventor(s)
      金 惠淑、綿矢 有佑、佐藤 聡、土居 弘幸
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗マラリア剤2014

    • Inventor(s)
      金 惠淑、綿矢 有佑、佐藤 聡、土居 弘幸
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-214605
    • Filing Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗マラリア剤2014

    • Inventor(s)
      金 惠淑、綿矢 有佑、佐藤 聡、土居 弘幸
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-214606
    • Filing Date
      2014-10-21
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-01  

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