Joint Cooperative Research for Endemic Diseases Control in Ghana
Project/Area Number |
25305008
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Parasitology (including sanitary zoology)
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Research Institution | Okayama University |
Principal Investigator |
KIM Hye-Sook 岡山大学, 医歯(薬)学総合研究科, 准教授 (70314664)
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Co-Investigator(Kenkyū-buntansha) |
DOI Hiroyuki 岡山大学, 大学院医歯薬学総合研究科, 教授 (20452568)
KATO Nobuyuki 岡山大学, 大学院医歯薬学総合研究科, 教授 (40150883)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | マラリア / リーシュマニア症 / HCV / 遺伝子解析 / 創薬シーズ / 風土病 / 疫学 / リーシュマニア / 疫学調査 |
Outline of Final Research Achievements |
The epidemiological study of Leishmaniasis was L. major only using lesion of several different parts of patients and major vector was S. Africana in the Volta region. In the genetic analysis of drug-resistant malaria, most of the patient samples collected after 2010 showed a drug-sensitive gene type and one of reason of the result was caused by Ghana government malaria treatment-polish was changed to Artemisinin-based combination therapy than other classical malaria drugs.To effective analysis of HCV patient in Ghana, the universal primer-set was determined in the 5'-untranslated region of HCV genome. We found a new drug discovery seeds showing the ability to inhibit both of malaria and leishmaniasis using in Milletia Thonningii of Ghanaian natural products.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Improvement of oral bioavailability of N-251, a novel antimalarial drug, by long-chain fatty acid-based self-microemulsifying drug delivery system2015
Author(s)
Imada, C., Takahashi, T., Kuramoto, M., Masuda, K., Ogawara, K., Sato, A., Wataya, Y., Kim, H.-S. and Higaki, K
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Journal Title
Pharm. Res.,
Volume: 32 (8)
Pages: 2595-2608
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum.2015
Author(s)
Morita, M., Koyama, T., Sanai, H., Sato, K., hiramoto, A., Masuyama, A., Nojima, M., Wataya, Y. and Kim, H.-S
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Journal Title
Parasitol. Int.
Volume: 64
Issue: 1
Pages: 113-117
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] New preclinical antimalarial drugs potently inhibit hepatitis C virus genotype 1b RNA replication2013
Author(s)
Ueda, Y., Takeda, M., Mori, K., Dansako, H., Wakita, T., Kim, H.-S., Sato, A., Wataya, Y., Ikeda, M. and Kato, N.
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Journal Title
PLosOne,
Volume: 8
Pages: 1-11
NAID
Related Report
Peer Reviewed
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[Journal Article] Applications of triphenylpyrylium salt-sensitized electron transfer photo-oxygenation reactions to the synthesis of benzo-fused 1,4-diaryl-2,3- dioxabicyclo[2.2.2]octanes as new antimalarial cyclic peroxides.2013
Author(s)
Kamata, M., Hagiwara, J., Hokari,T., Suzuki,C., Fujino,R., Kobayashi,S., Kim,H.-S. and Wataya, Y
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Journal Title
Research on Chemical Intermediate
Volume: 39
Pages: 127-137
Related Report
Peer Reviewed
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