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Studies on Lassa fever which is endemic in South-east area of Nigeria

Research Project

Project/Area Number 25305016
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Virology
Research InstitutionNagasaki University

Principal Investigator

YASUDA Jiro  長崎大学, 熱帯医学研究所, 教授 (10282518)

Co-Investigator(Renkei-kenkyūsha) KUROSAKI Yohei  長崎大学, 熱帯医学研究所, 助教 (40415443)
URATA Shuzo  長崎大学, 熱帯医学研究所, 助教 (20614449)
Research Collaborator Uche Sonny Unigwe  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsラッサ熱 / ラッサウイルス / ナイジェリア / 次世代シーケンサー / 国際研究者交流 / ウイルス / 感染症
Outline of Final Research Achievements

Lassa fever caused by Lassa virus with high virulence is serious problem in West Africa, especially in Nigeria. In this study, we collected 121 serum samples from suspected patients in South-east area of Nigeria during 2012-2016 and analyzed. RT-PCR assay showed that 32 samples were positive for Lassa virus. Genetic analyses for virus genes revealed that Lassa virus has been genetically conserved without any positive selection for long time in this area. In addition, analysis with a next generation sequencer suggested that E. coli O157:H7 may be involved in the increased lethality of Lassa virus infection in this area.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (2 results)

All 2014 2013

All Presentation (2 results) (of which Invited: 1 results)

  • [Presentation] ナイジェリアのラッサ熱疑い患者血清対する次世代シーケンサーを用いた病原体解析2014

    • Author(s)
      宮崎 幸子、浦田 秀造、Unigwe Sonny Uche、安田 二朗
    • Organizer
      日本ウイル学会九州支部会
    • Place of Presentation
      鹿児島(城山観光ホテル)
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Emerging Infectious Disease Research in Connection with Plans for a BSL-4 Facility2013

    • Author(s)
      安田二朗
    • Organizer
      2013 US-Japan Medical Biosecurity and Biodefense Research Symposium
    • Place of Presentation
      Bethesda, MD, USA
    • Related Report
      2013 Annual Research Report
    • Invited

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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