Significance of specific antibodies against chemical substances as health effect markers

• Project/Area Number: 25340064
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental impact assessment
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Kawamoto Toshihiro 産業医科大学, 医学部, 教授 (60177748)
• Co-Investigator(Kenkyū-buntansha): 辻 真弓 産業医科大学, 医学部, 准教授 (40457601)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 環境 / アレルギー / 健康影響評価委 / 特異的抗体 / 化学物質 / タンパク質 / プラスチック / 樹脂 / 健康影響評価

Outline of Final Research Achievements

研究成果の概要（英文）：A new method to semi-quantitatively measure serum antibodies against plastic resin materials were developed by using western-dot blotting. The method was highly reproducible and reliable. Existing allergy markers other than the serum antibodies against plastic resin materials were not related to the dermatitis caused by epoxy resins. The antibodies from chemical allergy patient reacted with all chemico-human serum albumin complexes.

Research Products

• [Journal Article] Comparative study on three different methods for arm-span measurement: the Japan environment and Children’s study pilot. (2017)
  • Author(s): Tsuji M, Ayabe T, Tanaka R, Senj A, Shibata E, Araki S, Morokuma S, Sanefuji M, Kusuhara K, Kawamoto T.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 22 Issue: 1 Pages: 28-28
  • DOI: 10.1186/s12199-017-0632-9
  • NAID: 210000130200
  • Peer Reviewed / Open Access
• [Journal Article] Heme oxygenase 1 protects ethanol-administered liver tissue in Aldh2 knockout mice (2016)
  • Author(s): Akiko Matsumoto, David Thompson, Ying Chenc, Vasilis Vasiliouc, Toshihiro Kawamoto, Masayoshi Ichiba
  • Journal Title: Alcohol Volume: 52 Pages: 49-54
  • DOI: 10.1016/j.alcohol.2016.02.004
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury (2016)
  • Author(s): Ishihara Y, Tsuji T, Kawamoto T, Yamazaki T.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 59 Issue: 3 Pages: 182-190
  • DOI: 10.3164/jcbn.16-19
  • NAID: 130005268734
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment and Children's Study (JECS). (2016)
  • Author(s): Morokuma S, Shimokawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Senju A, Kawamoto T, Kusuhara K; Japan Environment & Children’s Study Group..
  • Journal Title: BMC Pregnancy Childbirth. Volume: 26;16:247. Issue: 1 Pages: 247-247
  • DOI: 10.1186/s12884-016-1041-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The association between maternal psychological stress and inflammatory cytokines in allergic young children. (2016)
  • Author(s): Tsuji M, Koriyama C, Yamamoto M, Anan A, Shibata E, Kawamoto T
  • Journal Title: PeerJ Volume: 4 Pages: 1585-1596
  • DOI: 10.7717/peerj.1585
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of IgG against plastic resin in workers with and without chemical dermatitis (2015)
  • Author(s): Kawamoto T, Tsuji M, Isse T.
  • Journal Title: BMC Public Health Volume: 15 Issue: 1 Pages: 93-93
  • DOI: 10.1186/s12889-015-2302-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives (2015)
  • Author(s): Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ
  • Journal Title: Endocrinology Volume: 156 (10) Issue: 10 Pages: 3408-3415
  • DOI: 10.1210/en.2015-1350
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium (2015)
  • Author(s): Amanuma Y, Ohashi S, Itatani Y, Tsurumaki M, Matsuda S, Kikuchi1 O, Naka Y, Miyamoto S, Oyama T, Kawamoto T, Whelan KA, Nakagawa H, Chiba T, Matsuda T, Muto M
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 14142-14142
  • DOI: 10.1038/srep14142
  • NAID: 120005678158
  • Peer Reviewed / Open Access
• [Journal Article] Association of PCBs and allergies in children. (2015)
  • Author(s): Tsuji M, Kawamoto T, Koriyama C, Yamamoto M, Tsuchiya T, Matsumura F
  • Journal Title: Pesticide Biochemistry and Physiology Volume: 120 Pages: 21-26
  • DOI: 10.1016/j.pestbp.2014.10.014
  • Peer Reviewed
• [Journal Article] The Japan Environment and Children’s Study (JECS): A Preliminary Report on Selected Characteristics of Approximately 10 000 Pregnant Women Recruited During the First Year of the Study (2015)
  • Author(s): Michikawa T, Nitta H, Nakayama SF, Ono M, Yonemoto J, Tamura K, Suda E, Ito H, Takeuchi A, Kawamoto T, for the Japan Environment and Children’s Study Group
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 6 Pages: 452-458
  • DOI: 10.2188/jea.JE20140186
  • NAID: 130005074463
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR (2014)
  • Author(s): Aiko Y, Askew DJ, Aramaki S, Myoga M, Tomonaga C, Hachsuga H, Suga R, Kawamoto T, Tsuji T, Shibata E
  • Journal Title: BMC Pregnancy and Childbirth Volume: 14 Pages: 181-181
  • Peer Reviewed / Open Access
• [Journal Article] Ethanol reduces Lifespan, body weight and serum alanine aminotransferase level of aldehysde dehydrogenase 2 knockout mouse (2014)
  • Author(s): Matsumoto A, Vasiliou V, Kawamoto T, Tanaka K, Ichiba M
  • Journal Title: Alocoholism: Clinical and Experimental Research Volume: 38 Issue: 7 Pages: 1883-1893
  • DOI: 10.1111/acer.12462
  • Peer Reviewed
• [Journal Article] Harmonizing Biomarker Measurements in Longitudinal Studies of Children’s Health and the Environment. (2014)
  • Author(s): Etzel R, Charles M-A, Dellarco M, Gajeski K, Jockel K-H, SHirschfeld S, Kamijima M, Kawamoto T, Kolossa-Gehring M, Nakayama S, Schmidt B, Tian Y, Wolz B, Zaros C, Zhang J
  • Journal Title: Biomonitoring Volume: 1 Pages: 50-62
  • Peer Reviewed
• [Journal Article] Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice (2014)
  • Author(s): Hyo-Jung Kwon, Young-Suk Won, Ogyi Park, Binxia Chang, Michael J. Duryee, Geoffrey E. Thiele, Akiko Matsumoto, Surendra Singh, Mohamed A. Abdelmegeed, Byoung-Joon Song, Toshihiro Kawamoto, Vasilis Vasiliou, Geoffrey M. Thiele, Bin Gao
  • Journal Title: Hepatology . Volume: 60 Issue: 1 Pages: 146-157
  • DOI: 10.1002/hep.27036
  • Peer Reviewed
• [Journal Article] Rationale and study design of the Japan (2014)
  • Author(s): Kawamoto T, Nitta H, Murata K, et al.
  • Journal Title: BMC Public Health Volume: 14 Pages: 25-25
  • Peer Reviewed
• [Journal Article] Polychlorinated Biphenyls (PCBs) decrease the Placental Syncytiotrophoblast Volume and increase Placental Growth Factor (PIGF) in the placenta of normal pregnancy (2013)
  • Author(s): Mayumi Tsuji; Yukiyo Aiko; David J Askew; Toshiro Kawamoto; Tohru Hachisuka;Chihaya Kooriyama;Mai Myoga; Chiharu Tomonaga; Fumio Matsumura; Ayumi Anan; Masayuki Tanaka; Hsu-Sheng Yu; Yasuko Fujisawa; Reiko Suga; Eiji Shibata
  • Journal Title: PLACENTA Volume: (In press) Issue: 7 Pages: 1-5
  • DOI: 10.1016/j.placenta.2013.03.007
  • Peer Reviewed
• [Journal Article] ubchronic exposure to ethyl tertiary butyl ether resulting in genetic damage in Aldh2 knockout mice (2013)
  • Author(s): Weng Z,Suda M,Ohtani K,Mei N,Kawamoto T,Nakajima T,Wang RS
  • Journal Title: Toxicology Volume: 311 Issue: 3 Pages: 107-114
  • DOI: 10.1016/j.tox.2013.06.005
  • Peer Reviewed
• [Presentation] Diagnostic significance of specific immunoglobulin G against plastic resins. (2017)
  • Author(s): Kawamoto T.
  • Organizer: The 8th National Conference on Occupational and Environmental Diseases & The 1st International Conference on Occupational and Environmental Diseases.
  • Place of Presentation: Miracle Grand Convention Hotel, Bangkok, Thailand.
  • Year and Date: 2017-03-01
  • Int'l Joint Research / Invited
• [Presentation] Present status and preliminary results of JECS (Japan Environment and Children’s Study) (2016)
  • Author(s): Kawamoto T, Nitta H, Nakayama SF, Michikawa T, Suzuki K, Yamamoto-Harada K.
  • Organizer: ISEE-ISES AC2016, Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter 2016.
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26
  • Int'l Joint Research / Invited
• [Presentation] Detection of specific immunoglobulin G against plastic resin in workers with dermatitis (2015)
  • Author(s): Kawamoto T, Tsuji M, Tsuchiya T
  • Organizer: International Symposium of Environmental Science 25th Meeting
  • Place of Presentation: Henderson, Nevada、USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] 環境中の化学物質と小児の健康 (2015)
  • Author(s): 川本俊弘
  • Organizer: 第29回日本医学会総会
  • Place of Presentation: 京都大学百周年時計台記念館 （京都府・京都市）
  • Year and Date: 2015-04-12
  • Invited
• [Presentation] Present status of JECS (Japan Environment and Children’s Study) and its utilization as an individual researcher (2014)
  • Author(s): Kawamoto T.
  • Organizer: International Symposium of Environmental Medicine. NTUH Environmental Medicine Collaboration Center (EMC2)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-10-16 – 2014-10-17
  • Invited
• [Presentation] Challenges of Connecting Environmental Toxicology and the Epidemiology of Childhood Allergies (2014)
  • Author(s): Tsuji M, T Kawamoto T, Matsumura F
  • Organizer: 248th ACS National Meeting
  • Place of Presentation: San Francisco, CA
  • Year and Date: 2014-08-10
• [Presentation] 環境中化学物質が小児に与える影響の検討 (2014)
  • Author(s): 辻 真弓、川本俊弘、Fumio Matsumura
  • Organizer: 第41回日本毒性学会学術年会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2014-07-02 – 2014-07-04
• [Presentation] Specific antibodies against plastic resins (2013)
  • Author(s): Kawamoto T, Tsuji M
  • Organizer: Conference of ISEE, ISES and ISIAQ
  • Place of Presentation: Basel, Switzerland
• [Presentation] Development of evaluating methods for sensitizing chemicals by using chemico-protein adducts (2013)
  • Author(s): Kawamoto T, Tsuji M
  • Organizer: The XIII International Congress of Toxicology
  • Place of Presentation: Seoul, Korea
• [Patent(Industrial Property Rights)] 合成樹脂原料モノマーまたは合成樹脂前駆体への曝露の検出方法 (2013)
  • Inventor(s): 川本俊弘 吉田安宏 一瀬豊日
  • Industrial Property Rights Holder: 学校法人産業医科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-19
  • Acquisition Date: 2015-06-12