The biological meaning of neurite outgrowth via bisphenol A and its receptor
Project/Area Number |
25340104
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Environmental risk control and evaluation
|
Research Institution | Kansai University |
Principal Investigator |
SHIMOKE KOJI 関西大学, 化学生命工学部, 教授 (10351496)
|
Co-Investigator(Kenkyū-buntansha) |
IKEUCHI Toshihiko 関西大学, 化学生命工学部, 教授 (20093362)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | bisphenol A / PC12細胞 / 大脳皮質神経細胞 / エピジェネティクス / 環境ホルモン / 生態評価 / 神経突起 / 神経細胞 / ビスフェノールA / 甲虫モデル / 極性 / 発生 |
Outline of Final Research Achievements |
This research has been performed because of finding the neurite extending effect of bisphenol A(BPA), which belongs to endocrine disrupting chemicals. The research by others has been remitted to the sexual effect although ours focus on neurons. The results are that BPA induced neurite outgrowth with bipolarization on soma through histone H3 modification (acetylation) on specific lysine residue.
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Report
(4 results)
Research Products
(14 results)