Effect of probiotics on Nonalcholic fatty liver disease
Project/Area Number |
25350132
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
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Research Institution | Okayama Prefectural University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
田淵 真愉美 岡山県立大学, 保健福祉学部, 准教授 (60389020)
湯浅 明子 (小島明子 / 小島 明子 / 湯浅 明子(小島明子)) 大阪市立大学, 大学院生活科学研究科, 准教授 (90295709)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | NAFLD / プロバイオティクス / 肥満 / 機能性食品 / NASH / n-3系脂肪酸 |
Outline of Final Research Achievements |
We focused on anti-obesity effect of probiotics on progression of nonalcoholic fatty liver disease (NAFLD). In this study, we observed that visceral fat accumulation and NAS (NAFLD activity score) in obese mice fed with probiothics (Lactobacillus plantarum 301102) and prebiotics was significantly lower than control mice. We also showed that omega 3 fatty acid rich seal oil supplementation on NASH model mouse decreased NAS significantly. This study suggests that the anti-inflammatory and anti-obesity effect of L.plantaram and/or seal oil might be preservation of hepatic function in NAFLD. Further examination including mechanism of mediators from intestinal bacterial flora or adipose tissue on chronic liver disease should be performed.
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Report
(5 results)
Research Products
(6 results)