Effect of probiotics on Nonalcholic fatty liver disease

• Project/Area Number: 25350132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Okayama Prefectural University
• Principal Investigator: Kawakami Takayo 岡山県立大学, 保健福祉学部, 教授 (10254567)
• Co-Investigator(Kenkyū-buntansha): 田淵 真愉美 岡山県立大学, 保健福祉学部, 准教授 (60389020) ; 湯浅 明子 (小島明子 / 小島 明子 / 湯浅 明子(小島明子)) 大阪市立大学, 大学院生活科学研究科, 准教授 (90295709)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: NAFLD / プロバイオティクス / 肥満 / 機能性食品 / NASH / n-3系脂肪酸

Outline of Final Research Achievements

We focused on anti-obesity effect of probiotics on progression of nonalcoholic fatty liver disease (NAFLD). In this study, we observed that visceral fat accumulation and NAS (NAFLD activity score) in obese mice fed with probiothics (Lactobacillus plantarum 301102) and prebiotics was significantly lower than control mice. We also showed that omega 3 fatty acid rich seal oil supplementation on NASH model mouse decreased NAS significantly. This study suggests that the anti-inflammatory and anti-obesity effect of L.plantaram and/or seal oil might be preservation of hepatic function in NAFLD. Further examination including mechanism of mediators from intestinal bacterial flora or adipose tissue on chronic liver disease should be performed.

Research Products

• [Journal Article] NAFLDにおける緑色野菜ジュースの飲用が血清ALT値に及ぼす影響 (2015)
  • Author(s): 田淵真愉美、久保木真、水道裕久、河原和枝、冨岡加代子、川上貴代、平松智子、塚本幾代
  • Journal Title: 岡山県立大学保健福祉学部紀要 Volume: 22 Pages: 27-38
  • NAID: 120005714084
  • Peer Reviewed
• [Presentation] 非アルコール性脂肪性肝炎モデルマウス肝における血小板型12S-リポキシゲナーゼの発現 (2016)
  • Author(s): 森 香子、大槻 朱美、川上 祐生、神崎 圭太、山本 登志子、川上 貴代、木本 眞順美、 山下 広美、高橋 吉孝
  • Organizer: 第89回日本生化学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] Seal oil attenuates hepatic inflammation in NASH model mice. (2015)
  • Author(s): Kawakami T, Murakami Y, Tabuchi M, Hiramatsu S, Mihara M
  • Organizer: 12th Asian Congress of Nutrition (12th ACN2015)
  • Place of Presentation: Minatomirai, Yokohama
  • Year and Date: 2015-05-15 – 2015-05-17
• [Presentation] Seal oil attenuates hepatic inflammation in NASH model mice (2015)
  • Author(s): Takayo Kawakami, Yasuko Murakami, Mayumi Tabuchi, Satoko Hiramatsu, Miho Mihara
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Pacifico Yokohama, Yokohama
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Rｅｌａｔｉｏｎｓｈｉｐ ｂｅｔｗｅｅｎ ｏｘｉｄａｔｉｖｅ ｓｔｒｅｓｓ ｍａｒｋｅｒｓ ａｎｄ ｆａｔｔｙ ａｃｉｄ ｃｏｍｐｏｓｉｔｉｏｎｓ ｏｆ ｓｅｒｕｍ ｐｈｏｓｐｈｏｌｉｐｉｄｓ． (2013)
  • Author(s): Tomioka K, Mizote T, Tabuchi M, Kawakami T, Haisa S , Takahashi Y
  • Organizer: Asia Pacific Conference on Clinical Nutrition (APCCN2013)
  • Place of Presentation: Tokyo Bay Maihama Hotel Club Resorｔ，Ｔｏｋｙｏ
• [Presentation] Rｅｌａｔｉｏｎｓｈｉｐ ｂｅｔｗｅｅｎ ｄｉｅｔａｒｙ ｎｕｔｉｒｉｅｎｔｓ ａｎｄ ｏｘｉｄａｔｉｖｅ ｓｔｒｅｓｓ ｍａｒｋｅｒｓ． (2013)
  • Author(s): Tomioka K, Mizote T, Tabuchi M, Kawakami T, Haisa S , Takahashi Y
  • Organizer: IUNS 20th International Conference of Nutrition
  • Place of Presentation: GranadaCongress Centre，Granada，Ｓｐａｉｎ