Visualization of in vivo mouse coronary arteries using high intensity quasi-monochromatic x-rays generated by an x-ray mirror
Project/Area Number |
25350547
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Japan Synchrotron Radiation Research Institute |
Principal Investigator |
Keiji Umetani 公益財団法人高輝度光科学研究センター, 利用研究促進部門, 主幹研究員 (50344396)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | マウス冠状動脈撮影 / 血管造影 / 放射光 / X線ミラー / 準単色X線 / 心臓疾患診断 / マウス冠状動脈 / 心臓疾患 |
Outline of Final Research Achievements |
Rat coronary microangiography at the SPring-8 synchrotron radiation facility has been applied to numerous pre-clinical studies by visualization of fine angioarchitectures comparable with those of human angiographic anatomy. Next, we undertook new studies on visualization of mouse coronary arteries because a lot of disease model mice can be produced by gene recombination. We developed a new high-speed imaging system using a combination of high intensity quasi-monochromatic x-rays generated by an x-ray mirror and a sub-millisecond precision x-ray shutter because mouse bodies are smaller than those of rats and mouse heart rates are faster than those of rats. The new system will be an effective tool for pharmacometrics and studies on disease mechanisms using various types of disease model mice.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Sympathetic hyper-excitation in obesity and pulmonary hypertension - physiological relevance to the 'Obesity Paradox'2016
Author(s)
Crystal Diong, Peter Jones, Hirotsugu Tsuchimochi, Emily Gray, Gillian Hughes, Tadakatsu Inagaki, Carol Bussey, Yutaka Fujii, Keiji Umetani, Mikiyasu Shirai, Daryl Schwenke
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Journal Title
International Journal of Obesity
Volume: 40
Issue: 6
Pages: 938-946
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of pro-angiogenic microRNAs2016
Author(s)
Rajesh Katare, Shruti Rawal, Pujika E Munasinghe, Parul Dixit, Hirotsugu Tsuchimochi, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Kenji Kangawa, Mikiyasu Shirai, Daryl Schwenke
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Journal Title
Endocrinology
Volume: 157
Issue: 2
Pages: 432-445
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Altered blood flow in cerebral perforating arteries of rat models of diabetes: A synchrotron radiation microangiographic study toward clinical evaluation of white matter hyperintensities2015
Author(s)
Naoto Fukuyama, Yuko Tsukamoto, Shunya Takizawa, Yoshimori Ikeya, Toshiharu Fujii, Yoshiro Shinozaki, Yoko Takahari, Noboru Kawabe, Noriaki Wakana, Keiji Umetani, Kikue Todoroki, Sayato Fukui, Chiharu Tanaka, Etsuro Tanaka, Hidezo Mori
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Journal Title
Geriatrics & Gerontology International Supplement
Volume: 15
Issue: S1
Pages: 74-80
DOI
Related Report
Peer Reviewed
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[Journal Article] Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia2015
Author(s)
Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Sayoko Ogura, Takashi Sonobe, Tadakatsu Inagaki, Yutaka Fujii, Rutsuko Yamaguchi, Lisa Wingenfeld, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, Koichi Uemura, James T. Pearson, Mikiyasu Shirai
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Journal Title
PLoS ONE
Volume: 10
Issue: 7
Pages: 1-20
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart.2015
Author(s)
Kainuma S, Miyagawa S, Fukushima S, Pearson J, Chen YC, Saito A, Harada A, Shiozaki M, Iseoka H, Watabe T, Watabe H, Horitsugi G, Ishibashi M, Ikeda H, Tsuchimochi H, Sonobe T, Fujii Y, Naito H, Umetani K, Shimizu T, Okano T, Kobayashi E, Daimon T, Ueno T, Kuratani T, Toda K, Takakura N, Hatazawa J, Shirai M, Sawa Y.
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Journal Title
Mol Ther
Volume: 23
Issue: 2
Pages: 374-386
DOI
Related Report
Peer Reviewed
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[Journal Article] Beta2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats2014
Author(s)
Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Tadakatsu Inagaki, Sayoko Ogura, Yutaka Fujii, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, James T. Pearson, Koichi Uemura, Mikiyasu Shirai
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Journal Title
PLOS ONE
Volume: 10
Issue: 10
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia2014
Author(s)
Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hisashi Nagai, Emily Gray, James Todd Pearson, Takashi Sonobe, Misa Yoshimoto, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Ichiro Kuwahira, Daryl Schwenke
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Journal Title
Basic Research in Cardiology
Volume: 109
Issue: 5
Pages: 432-432
DOI
Related Report
Peer Reviewed
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[Presentation] Microstructure analysis of the pulmonary acinus using a synchrotron radiation CT2015
Author(s)
Yoshitaka Tokumoto, Koichi Minami, Yoshiki Kawata, Noboru Niki, Keiji Umetani, Yasutaka Nakano, Hiroaki Sakai, Hironobu Ohmatsu, Harumi Itoh
Organizer
SPIE Medical Imaging
Place of Presentation
Renaissance Orlando (Orlando, Florida, USA)
Year and Date
2015-02-21 – 2015-02-26
Related Report
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