Comprehensive analysis of gene expression induced by muscle contraction in three-dimensional tissue-engineered muscle.
| Project/Area Number |
25350830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Osaka Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Fujisato Toshia 大阪工業大学, 工学部, 教授 (60270732)
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| Co-Investigator(Renkei-kenkyūsha) |
Okuzaki Daisuke 大阪大学, 微生物病研究所, 助教 (00346131)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ３次元培養筋 / 網羅的解析 / マイオカイン / 三次元培養筋 / マイクロアレイ / 三次元培養骨格筋 / 電気刺激 / バイオインフォマテックス / 身体活動意義 |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate a novel role of muscle contraction by comprehensive gene analysis using three-dimensional tissue-engineered muscle.
Comprehensive gene analysis indicated that many genes encoding secretory proteins upregulated with muscle contraction. Furthermore, a gene associated feeding behavior included within the gene pool. Taken together, It is likely that skeletal muscles actively communicate and regulate remote organs through the production of secretory proteins by muscle contraction.
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Report
(4 results)
Research Products
(10 results)
