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Study on depresive symptoms and metabolic symdrome in community-dwelling older adults

Research Project

Project/Area Number 25350883
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKanazawa University

Principal Investigator

TSUBOI HIROHITO  金沢大学, 薬学系, 准教授 (20319338)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsうつ / 高齢者 / 社会的サポート / 慢性炎症 / 酸化 / 抑うつ / サポートの授受 / 社会経済的要因 / 地域高齢者 / 心身 / 社会経済的状況 / 男女差 / 年齢
Outline of Final Research Achievements

[Study 1] We analyzed epidemiological data, which consists of healthy elderly residents (1,869 male and 12,763 female). Although age, having serious diseases, SES, living alone (only among men) and social supports were important factors to predict higher or lower depressive symptoms, the former three variables are difficult to change. By contrast, social supports are ameliorable factors. We found an important factor: giving support to outside family can be a better buffer against depression than receiving support in both men and women. In the relation to husband and wife, spousal supports were significant factors against depressive symptoms, though there were some, if any, differences between receiving and giving supports against depressive symptoms.
[Study 2] We also carried out a study on 128 female workers of a hospital and nursing homes. Depressive symptoms were significantly correlated with serum IL-6 levels and oxidation rate of LDL-cholesterol.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Giving social supports to outside family can be a desirable buffer against depressive symptoms in community-dwelling older adults: Japan Gerontological Evaluation Study2016

    • Author(s)
      Hirohito Tsuboi, Hiroshi Hirai, Katsunori Kondo
    • Journal Title

      BioPsychoSocial Medicine

      Volume: in press Issue: 1 Pages: 18-28

    • DOI

      10.1186/s13030-016-0064-6

    • NAID

      130005399418

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Depressive symptoms and their association with serum creatine kinase and lactate dehydrogenase in female nursing staff working under stressful environment - A preliminary study2014

    • Author(s)
      Ayako Kato Hiroyuki Sakakibara Hirohito Tsuboi Asami Tatsumi, Masanobu Akimoto Kayoko Shimoi Takeshi Ishii Hiroshi Kaneko Tsutomu Nakayama, Norio Ohashi.
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 8 Issue: 1

    • DOI

      10.1186/1751-0759-8-21

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antibiotic utilization in a dental teaching hospital in Yogyakarta, Indonesia.2014

    • Author(s)
      Mayu Winnie Rachmawati, Naoko Yoshida, Hirohito Tsuboi, Kazuko Kimura
    • Journal Title

      Science Journal of Clinical Medicine

      Volume: 3 Pages: 37-42

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of Antibiotic Use at a Dental Teaching Hospital in Yogyakarta, Indonesia: A Review from Guidelines.2014

    • Author(s)
      Mayu Winnie Rachmawati, Naoko Yoshida, Hirohito Tsuboi, Kazuko Kimura
    • Journal Title

      Pharmacology & Pharmacy

      Volume: 5 Issue: 05 Pages: 524-531

    • DOI

      10.4236/pp.2014.55062

    • NAID

      120006580762

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A cross-sectional investigation of the quality of selected medicines in Cambodia in 2010.2014

    • Author(s)
      Naoko Yoshida, Mohiuddin Hussain Khan, Hitomi Tabata, Eav Dararath, Tey Sovannarith, Heng Bun-Kiet, Nam Nivanna, Manabu Akazawa, Hirohito Tsuboi, Tsuyoshi Tanimoto, Kazuko Kimura
    • Journal Title

      BMC Pharmacol Toxicol

      Volume: 15 Issue: 1

    • DOI

      10.1186/2050-6511-15-13

    • NAID

      120005516435

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] やぶにらみ心身医学2014

    • Author(s)
      坪井宏仁
    • Journal Title

      心身医学

      Volume: 54 Pages: 395-396

    • NAID

      110009816744

    • Related Report
      2013 Research-status Report
  • [Journal Article] Analysis on Awareness of Functional Dyspepsia and Rome Criteria Among Japanese Internists by the Self-administered Questionnaires. ournal of Neurogastroenterology and Motility.2013

    • Author(s)
      Hiroshi Kaneko, Hirohito Tsuboi
    • Journal Title

      Journal of Neurogastroenterology and Motility

      Volume: 20 Issue: 1 Pages: 64-103

    • DOI

      10.5056/jnm.2014.20.1.94

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population - a preliminary study.2013

    • Author(s)
      Hirohito Tsuboi, Misuzu Watanabe, Fumio Kobayashi, Kazuko Kimura, Naohide Kinae
    • Journal Title

      Clinical Nutrition

      Volume: 32 Issue: 2 Pages: 289-293

    • DOI

      10.1016/j.clnu.2012.07.011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 地域高齢者における伴侶死別前後の抑うつと社会的サポートの男女差2015

    • Author(s)
      坪井宏仁
    • Organizer
      第39回 生命情報科学シンポジウム総会
    • Place of Presentation
      (東邦大学大森キャンパス)東京
    • Year and Date
      2015-03-17 – 2015-03-18
    • Related Report
      2014 Research-status Report
  • [Presentation] The serum levels of n-3 fatty acids and IL-6 were independently associated with depressive symptoms in female population.2014

    • Author(s)
      Hirohito Tsuboi, Hiroyuki Sakakibara, Asami Tatsumi, Kimiko Yamakawa-Kobayashi, Hiroshi Kaneko, Masahiro Matsunaga, Kayoko Shimoi.
    • Organizer
      The 21st Annual Meeting of the Psychoneuroimmunology Research Society
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2014-05-28 – 2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 機能性消化管障害診療からの提言(社会のニーズにこたえる消化器疾患の診療)2013

    • Author(s)
      金子宏、坪井宏仁
    • Organizer
      第17回日本心療内科学会総会・学術大会
    • Place of Presentation
      九州大学(福岡)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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