Inhibiting effect of blood flow restriction on skeletal muscle atrophy and investigation of related genes
| Project/Area Number |
25350899
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKEI Saori 順天堂大学, 大学院医学(系)研究科(研究院), 特任助教 (00450560)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血流制限 / 筋萎縮 / 遺伝子発現 |
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| Outline of Final Research Achievements |
Expression levels of genes influencing skeletal muscle protein synthesis and breakdown were analyzed after immobilizing the human lower extremity in a cast as a model of muscle atrophy and weakness to clarify the mechanisms of the preventing effect of repeated local blood flow restriction on muscle atrophy and weakness. It was suggested that the regulation of gene expression level such as MuRF1, FoxO3, p70S6K may be involved in the mechanisms.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet2016
Author(s)
1.Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 310(1)
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study2014
Author(s)
Watanabe T, Tamura Y, Kakehi S, Funayama T, Takeno K, Kawaguchi M, Yamamoto L, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R, Watada H
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Journal Title
J Diabetes Invest
Volume: Mar;6(2)
Issue: 2
Pages: 164-72
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular-lipid-accumulated non-obese men2014
Author(s)
Kawaguchi M, Tamura Y, Kakehi S, Takeno K, Sakurai Y, Watanabe T, Funayama T, Sato F, Ikeda S, Ogura Y, Saga N, Naito H, Fujitani Y, Kanazawa A, Kawamori R, Watada
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Journal Title
J Clin Endocrinol Metab
Volume: Sep;99(9)
Issue: 9
Pages: 3343-52
DOI
Related Report
Peer Reviewed
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[Presentation] Intramyocellular lipid accumulation after high-fat diet is associated with the gene expression involved in lipid metabolism in skeletal muscle of non-obese men2015
Author(s)
3.Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H
Organizer
2nd Congress, International Academy of Sportology
Place of Presentation
Tokyo, Japan
Year and Date
2015-09-12
Related Report
Int'l Joint Research
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[Presentation] Accumulation of intramyocellular lipid after high-fat diet is associated with the expression of genes involved in lipid metabolism in non-obese men2014
Author(s)
Kakehi S, Tamura Y, TakenoK, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, and Watada H
Organizer
3rd international conference on Recent Advances and Controversies in Measuring Energy Metabolism
Place of Presentation
Tokyo, Japan
Year and Date
2014-10-10 – 2014-10-12
Related Report
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