| Project/Area Number |
25350904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kagawa Nutrition University |
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Principal Investigator |
Kagawa Yasuo 女子栄養大学, 栄養学部, 教授 (30048962)
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| Co-Investigator(Kenkyū-buntansha) |
IWAMOTO Sadahiko 自治医科大学, 医学部, 教授 (10232711)
KAMACHI Keiko 女子栄養大学, 付属研究所, 教授 (20365810)
TANAKA Akira 女子栄養大学, 栄養学部, 教授 (70171733)
KAWABATA Terue 女子栄養大学, 栄養学部, 教授 (80190932)
NAKAYAM Kazuhiro 自治医科大学, 医学部, 講師 (90433581)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 菜食者 / 遺伝子多型 / ドコサヘキサエン酸 / エイコサペンタエン酸 / アラキドン酸 / 脂肪酸不飽和化酵素 / 純菜食者 / 魚菜食者 / 菜食主義者 / 魚菜食 / 循環器疾患 / 和食 / ステアリドン酸 / 脂肪酸不飽和化酵素多型 / 血清脂肪酸 |
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| Outline of Final Research Achievements |
Purpose: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are needed to maintain health, but vegetarians hardly take them. Conversion of the plant-derived -linolenic acid (ALA) to EPA and DHA, and linoleic acid to arachidonic acid (AA) requires 5 desaturase, and the ability is lower in carriers of its genetic polymorphism (rs174547) C allele than those with T allele. Thus, the health status of the C allele carriers were surveyed.
Results: DHA intake of vegans + lactovegetarians was 0, and their serum and erythrocyte ALA was higher, and serum EPA and DHA were lower, and ω3 index was as low as 3.2 in TC/CC genotypes, and serum AA was much lower compared with those of TT genotype. The health indices of vegans + lactovegetarians were better than that of omnivores studied by Japanese National Nutrition Survey. The C carriers may keep health by their high EPA+DHA/AA ratio and preferentially preserve EPA/DHA to compensate low DHA intake.
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