Analysis of hydrogen effects on oxidative stress defense mechanisms and redox dynamics in the brain
Project/Area Number |
25350907
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Nippon Medical School |
Principal Investigator |
Nishimaki Kiyomi 日本医科大学, 先端医学研究所, マネージメントサポートスタッフ (00465345)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 酸化ストレス / 水素 / トランスジェニックマウス |
Outline of Final Research Achievements |
Accumulation of oxidative stress associated with aging is one of causative factors in the pathogenesis of major neurodegenerative diseases including Alzheimer’ and Parkinson diseases (AD and PD). In animal experiments using mitochondrial oxidative stress enhanced mice (DAL mouse), hydrogen molecules revealed that it is effective in removing oxidative stress associated with aging. In this study, we developed a transgenic mouse that can quantitatively evaluate the oxidative stress in the body and crossed with DAL mouse. We tried to visualize removal of oxidative stress using this double transgenic mouse.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease.2015
Author(s)
Kanamaru T, Kamimura N, Yokota T, Iuchi K, Nishimaki K, Takami S, Akashiba H, Shitaka Y, Katsura K, Kimura K, Ohta S.
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Journal Title
Neurosci Lett.
Volume: 587
Pages: 126-131
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease.2015
Author(s)
Kanamaru T, Kamimura N, Yokota T, Nishimaki K, Iuchi K, Lee H, Takami S, Akashiba H, Shitaka Y, Ueda M, Katsura K, Kimura K, Ohta S.
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Journal Title
Brain Res.
Volume: 1605
Pages: 49-58
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Accelerated Alzheimer-type Phenotype in transgenic mice carrying both mutant amyloid precursor protein and dominant-negative form of mitochondrial aldehyde dehydrogenase 22013
Author(s)
Naomi Kamimura, Kiyomi Nishimaki,Takuya Kanamaru, Takashi Yokota, Katsuya Iuchi, Shinya Takami, Hiroki Akashiba, Yoshitsugu Shitaka, Ken-ichiro Katsura, Yasuo Katayama, and Shigeo Ohta
Organizer
International Symposium on Mitochondria 2013
Place of Presentation
東京(六本木ヒルズ)
Related Report
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