2015 Fiscal Year Final Research Report
Analysis of hydrogen effects on oxidative stress defense mechanisms and redox dynamics in the brain
Project/Area Number |
25350907
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Nippon Medical School |
Principal Investigator |
Nishimaki Kiyomi 日本医科大学, 先端医学研究所, マネージメントサポートスタッフ (00465345)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 酸化ストレス / 水素 / トランスジェニックマウス |
Outline of Final Research Achievements |
Accumulation of oxidative stress associated with aging is one of causative factors in the pathogenesis of major neurodegenerative diseases including Alzheimer’ and Parkinson diseases (AD and PD). In animal experiments using mitochondrial oxidative stress enhanced mice (DAL mouse), hydrogen molecules revealed that it is effective in removing oxidative stress associated with aging. In this study, we developed a transgenic mouse that can quantitatively evaluate the oxidative stress in the body and crossed with DAL mouse. We tried to visualize removal of oxidative stress using this double transgenic mouse.
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Free Research Field |
分子生物学 生化学
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