| Project/Area Number |
25350914
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIFUNE Hiroharu 久留米大学, 医学部, 准教授 (70174117)
TAJIRI Yuji 久留米大学, 医学部, 准教授 (80469361)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062)
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| Research Collaborator |
HARA Kento
SAKAI Yusuke
OKABE Yuri
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グレリン / グレリン遺伝子欠損マウス / 日内リズム / 自発運動 / 時限制限給餌 / 探索行動 / Shift worker / 肥満 / 糖尿病 / 自律神経活動 / 心拍周期変動 / 周波数成分 / 運動療法 |
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| Outline of Final Research Achievements |
This study was undertaken to clarify a mechanism for the control of feeding rhythm or voluntary exercise by ghrelin, an appetite-promoting hormone, and a putative role of hits peptide in the crosstalk of feeding and exercise. Furthermore, we evaluated autonomic nervous activity in obese patients in relation to abnormal binge eating behavior often observed in these subjects. As a result, we demonstrated a crucial role of ghrelin surge in the maintenance of diurnal rhythm of either feeding or energy metabolism and in the formation of motivation for voluntary exercise. In obese patients, parasympathetic activity was suppressed during night, suggesting a possible contribution to blunted quality of life in these subjects.
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