| Project/Area Number |
25350956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
AMASAKI YOSHIKO 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 研究員(任非) (80435700)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKINUMA SHIZUKO 国立研究開発法人 量子化学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 部長 (20392219)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 胎児期 / 放射線 / 複合曝露 / 胸腺リンパ腫 / 胎児 / がん / Ikaros / 化学発がん |
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| Outline of Final Research Achievements |
We studied the combined effect of radiation exposure in utero, with ENU treatment at various times after birth, on T-cell lymphoma development using B6C3F1 mice. Combined radiation exposure with ENU treatment increased the T-cell lymphomas incidence significantly compared to irradiation at either 5 weeks old or E17.
ENU was more efficient at inducing T-cell lymphomas with shorter intervals following irradiation, at either age. These results suggest the effects of in utero irradiation may persist, and that sub-carcinogenic doses may still pose a risk with additional environmental exposures in later life.
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