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Screening and evaluation studies of the blood glucose level-regulatory compound through hepatic portal circulation system

Research Project

Project/Area Number 25350963
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomolecular chemistry
Research InstitutionTokyo University of Marine Science and Technology

Principal Investigator

KOYAMA TOMOYUKI  東京海洋大学, その他部局等, 准教授 (00377904)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords血糖値上昇抑制成分 / 消化器系疾患予防 / 血糖値上昇抑制 / 食品の機能性探索 / 栄養素の吸収調節 / 天然物有機化学 / 門脈血流量測定 / in vitro評価試験 / 消化器系疾患の予防 / 機能性食品素材 / in vivo評価試験
Outline of Final Research Achievements

This study is aimed to find a food material that regulates the absorption of nutritional components by changing the portal blood flow. Hence the screening study for food materials inhibiting elevation of the blood glucose level in glucose loading mice, and, the methods for evaluation on the portal blood flow rate and absorption of nutrients in mice were investigated. In the screening research, four active compounds were isolated from natural crude extract, and its activity and structure were determined. Then, the evaluation methods monitoring the blood flow using ultra sonic flow meter, and quantifying the blood components using clinical diagnostic kit were established in mice. As the results of evaluation with the purified compounds, I have not yet found the active compound suppressing an blood glucose levels by reducing the portal blood flow. These evaluation method can be useful and expected to be also applied for the evaluation of various digestive diseases.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds.2016

    • Author(s)
      Koyama T, Kawazoe Y, Iwasaki A, Ohno O, Suenaga K, Uemura D.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 69 Issue: 4 Pages: 348-351

    • DOI

      10.1038/ja.2016.19

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zonarol, a sesquiterpene from the brown algae Dictyopteris undulata, provides neuroprotection by activating the Nrf2/ARE pathway2015

    • Author(s)
      Hiroya Shimizu, Tomoyuki Koyama, Sohsuke Yamada, Stuart A Lipton, Takumi Satoh
    • Journal Title

      BBRC

      Volume: 457 Issue: 4 Pages: 718-722

    • DOI

      10.1016/j.bbrc.2015.01.059

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro.2014

    • Author(s)
      *Mukudai, Y, Kondo, S., Koyama, T., Li C., Banka, S., Kogure, A., Yazawa, K., Shintani, S.
    • Journal Title

      BMC Complement Altern Med.

      Volume: 14 Issue: 1 Pages: 29-29

    • DOI

      10.1186/1472-6882-14-29

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Marine hydroquinone zonarol prevents inflammation and apoptosis in dextran sulfate sodium-induced mice ulcerative colitis.2014

    • Author(s)
      Sohsuke Yamada*, Tomoyuki Koyama*, Hirotsugu Noguchi, Yuki Ueda, Ryo Kitsuyama, Hiroya Shimizu, Akihide Tanimoto, Ke-Yong Wang, Aya Nawata, Toshiyuki Nakayama, Yasuyuki Sasaguri, and Takumi Satoh.
    • Journal Title

      PLOS ONE

      Volume: 9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Root bark extracts of Juncus effusus and Paeonia suffruticosa protect salivary gland acinar cells from apoptotic cell death induced by cis-platinum (II) diammine dichloride2013

    • Author(s)
      Yoshiki Mukudai, Seiji Kondo, Sunao Shiogama, Tomoyuki Koyama, Chunnan Li, Kazunaga Yazawa, Satoru Shintani
    • Journal Title

      Oncology Reports

      Volume: 30 Issue: 6 Pages: 2665-2671

    • DOI

      10.3892/or.2013.2744

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大豆由来乳酸発酵物の脂質吸収抑制作用.2013

    • Author(s)
      小山智之、城﨑美幸.
    • Journal Title

      FOOD Style 21

      Volume: 17 Pages: 54-57

    • Related Report
      2013 Research-status Report
  • [Presentation] Marine hydroquinone zonarol prevents inflammation and apoptosis in dextran sulfate sodium-induced mice ulcerative colitis.2015

    • Author(s)
      Tomoyuki Koyama, Sohsuke Yamada, and Takumi Satoh.
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-hyperglycemic compounds isolated from Acer spp2015

    • Author(s)
      Fu Yun, Atsushi Honma, Toshiaki Ohshima, Tomoyuki Koyama
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 褐藻類シワヤハズ由来のゾナロールは潰瘍性大腸炎を抑制する2015

    • Author(s)
      山田壮亮、野口紘嗣、小山智之、名和田 彩、中山敏幸、佐藤拓己、笹栗靖之
    • Organizer
      第104 回日本病理学会総会(名古屋市、2015.4.30)
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Book] 植物工場野菜の栄養・機能性成分の分析・評価法,「植物工場経営の重要課題と対策2013

    • Author(s)
      高辻正基、古在豊樹、丸尾達、伊藤保、小山智之ほか
    • Total Pages
      464
    • Publisher
      情報機構
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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