Synthesis of novel inhibitors of the Hedgehog signaling pathway based on natural products
| Project/Area Number |
25350967
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomolecular chemistry
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ISHIBASHI MASAMI 千葉大学, 薬学研究科, 教授 (90212927)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ヘッジホッグシグナル / タエペエニンD / 構造活性相関 / 天然有機化合物 / シグナル伝達 / ケミカルバイオロジー / 天然物 |
|---|
| Outline of Final Research Achievements |
Synthesis of taepeenin D, an novel inhibitor of the Hedgehog (Hh) signaling pathway, was attempted. Considering the structure of taepeenin D, the synthesis commenced with easily available Wieland-Miescher ketone. First, selective functionalization at C19 methyl group was attempted as a key reaction. The reaction proceeded with high stereoselectivity. Second, short-step construction of benzofuran rings, a characteristic structure of taepeenin D, was accomplished.
|
Report
(4 results)
Research Products
(4 results)
