| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Synthesis of taepeenin D, an novel inhibitor of the Hedgehog (Hh) signaling pathway, was attempted. Considering the structure of taepeenin D, the synthesis commenced with easily available Wieland-Miescher ketone. First, selective functionalization at C19 methyl group was attempted as a key reaction. The reaction proceeded with high stereoselectivity. Second, short-step construction of benzofuran rings, a characteristic structure of taepeenin D, was accomplished.
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