Development of a microliter-scale high-throughput screening system with quantum-dot for amyloid-beta aggregation inhibitors
| Project/Area Number |
25350974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Muroran Institute of Technology |
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Principal Investigator |
TOKURAKU Kiyotaka 室蘭工業大学, 工学(系)研究科(研究院), 准教授 (00332106)
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| Co-Investigator(Renkei-kenkyūsha) |
UWAI Koji 室蘭工業大学, 工学研究科, 准教授 (80347905)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アミロイド / アルツハイマー / 凝集阻害物質 / スクリーニング / ハイスループット / 量子ドット / イメージング / 認知症 / 凝集阻害 / アルツハイマー病 / シソ科 / 香辛料 / 海藻 / ロスマリン酸 / ポリフェノール / Qdot / アミロイドβ |
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| Outline of Final Research Achievements |
The aggregation and accumulation of amyloid β protein (Aβ) is a key step in the pathogenesis of Alzheimer’s disease (AD), and therefore Aβ aggregation inhibitors may have preventive and/or therapeutic potential for AD. In this study, we developed a novel microliter-scale high-throughput screening (MSHTS) system for Aβ aggregation inhibitors using quantum-dot. Moreover, we tried to screen Aβ aggregation inhibitors by the MSHTS system from spice and seaweed extracts.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] A Microliter-Scale High-throughput Screening System with Quantum-Dot Nanoprobes for Amyloid-β Aggregation Inhibitors2013
Author(s)
Ishigaki, Y., Tanaka, H., Akama, H., Ogara, T., Uwai, K., and Tokuraku, K.
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Journal Title
PLoS ONE
Volume: 8
Issue: 8
Pages: e72992-e72992
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 海藻抽出物のAβ凝集阻害効果2015
Author(s)
高橋倫人、大柄俊貴、安井肇、上井幸司、徳楽清孝
Organizer
日本海水学会若手会第6回学生研究発表会
Place of Presentation
登別グランドホテル（北海道・登別）
Year and Date
2015-03-09 – 2015-03-10
Related Report
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[Presentation] 海藻類のアミロイド凝集阻害活性の評価2014
Author(s)
大柄俊貴、上井幸司、安井肇、徳楽清孝
Organizer
日本食品化学学会第20回総会・学術大会
Place of Presentation
東京ビッグサイト（東京都・江東区）
Year and Date
2014-05-21 – 2014-05-23
Related Report
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