| Project/Area Number |
25350974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Muroran Institute of Technology |
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Principal Investigator |
TOKURAKU Kiyotaka 室蘭工業大学, 工学(系)研究科(研究院), 准教授 (00332106)
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| Co-Investigator(Renkei-kenkyūsha) |
UWAI Koji 室蘭工業大学, 工学研究科, 准教授 (80347905)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アミロイド / アルツハイマー / 凝集阻害物質 / スクリーニング / ハイスループット / 量子ドット / イメージング / 認知症 / 凝集阻害 / アルツハイマー病 / シソ科 / 香辛料 / 海藻 / ロスマリン酸 / ポリフェノール / Qdot / アミロイドβ |
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| Outline of Final Research Achievements |
The aggregation and accumulation of amyloid β protein (Aβ) is a key step in the pathogenesis of Alzheimer’s disease (AD), and therefore Aβ aggregation inhibitors may have preventive and/or therapeutic potential for AD. In this study, we developed a novel microliter-scale high-throughput screening (MSHTS) system for Aβ aggregation inhibitors using quantum-dot. Moreover, we tried to screen Aβ aggregation inhibitors by the MSHTS system from spice and seaweed extracts.
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