| Project/Area Number |
25380926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical psychology
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| Research Institution | Osaka University |
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Principal Investigator |
IMURA OSAMU 大阪大学, 人間科学研究科, 教授 (20176506)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO TOSHIO 国立病院機構刀根山病院, 臨床研究部, 医師 (60538776)
MATSMURA TSUYOSHI 国立病院機構刀根山病院, 臨床研究部, 医師 (30549366)
FUJIMURA HARUTOSHI 国立病院機構刀根山病院, 臨床研究部, 医師 (20263246)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 筋ジストロフィー / 自閉スペクトラム症（ASD) / PARS-SF / SRS / エクソン / アイソフォーム / ジストロフィン遺伝子 / 自閉傾向 / ジストロフィン異常 / 心理的支援 / 自閉的傾向 / 発達障害 / PARS / CNS障害 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the association between the location of mutations in the dystrophin gene and autistic characteristics.Patients with dystrophinopathies (n = 56; mean age = 12.9, SD = 5.2) participated in this study. Autistic characteristics were assessed using PARS-SF and SRS.Eighteen patients (32.1%) showed autistic characteristics by the PARS-SF infantile rating, while 11 patients (19.6%) also scored above the cut-off value on the PARS-SF current rating. Two of seven patients (29%) with mutations in exon 30-44 and five of 25 patients (20%) with mutations in exon 45-55 exceeded the cut-off value in both the infantile and current ratings of PARS-SF, whereas none of the patients with mutations in the exons upstream of exon 30 did so.
We found significantly higher ASD characteristics in patients with mutations in exon 45-55 compared to patients with mutations upstream of exon 30.
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