Mechanism of heme transfer and metabolism by pathogenic bacteria
| Project/Area Number |
25410176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Azakami Hiroyuki 山口大学, 農学部, 教授 (40263850)
Nagano Shingo 鳥取大学, 工学研究科, 教授 (60286440)
Migita Catharina T 山口大学, 農学部, 教授 (90159161)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ヘム / 鉄 / 構造解析 / 機能解析 / 病原性細菌 |
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| Outline of Final Research Achievements |
Iron is a metal element essential for pathogenic bacteria, but the iron in host cells is tightly bound to proteins such as ferritin or transferrin. Under such circumstances, host heme could be a major source of iron. Some Gram-negative pathogens utilize an extracellular heme-binding protein called hemophore to satisfy their needs for iron. We elucidated heme transport in Pseudomonas aeruginosa, Yersinia pseudotuberculosis, and Eikenella corrodens by spectroscopic and crystallographic methods.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] An in vivo Inhibitory Effect on the Heme Uptake of Pseudomonas aeruginosa by its Hemophore (HasAp) Carrying Synthetic Metal Complexes2014
Author(s)
Shirataki, C., Shoji, O., Terada, M., Ozaki, S., Sugimoto, H., Shiro, Y., Watanabe, Y.
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Journal Title
Angew. Chem. Int. Ed.
Volume: 53
Pages: 1-6
Related Report
Peer Reviewed
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