| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Outline of Final Research Achievements |
Iron is a metal element essential for pathogenic bacteria, but the iron in host cells is tightly bound to proteins such as ferritin or transferrin. Under such circumstances, host heme could be a major source of iron. Some Gram-negative pathogens utilize an extracellular heme-binding protein called hemophore to satisfy their needs for iron. We elucidated heme transport in Pseudomonas aeruginosa, Yersinia pseudotuberculosis, and Eikenella corrodens by spectroscopic and crystallographic methods.
|
