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Development of new biological adhesive based on chitin derivatives and chitin nanofibers

Research Project

Project/Area Number 25410227
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Polymer/Textile materials
Research InstitutionTottori University

Principal Investigator

SAIMOTO HIROYUKI  鳥取大学, 工学(系)研究科(研究院), 教授 (20186977)

Co-Investigator(Renkei-kenkyūsha) OKAMOTO Yoshiharu  鳥取大学, 農学部, 教授 (50194410)
MORIMOTO Minoru  鳥取大学, 生命機能研究支援センター, 准教授 (10273880)
IFUKU Shinsuke  鳥取大学, 大学院工学研究科, 准教授 (70402980)
OSAKI Tomohiro  鳥取大学, 農学部, 准教授 (40431332)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsキチン / キトサン / 医用接着剤 / シーリング材料 / 生体適合性 / 医用材料 / 生体接着剤 / ナノファイバー
Outline of Final Research Achievements

Novel composite materials were made from chitin methacrylate derivatives and various chitin nanofibers. The adhesive strength of the chitin methacrylate derivatives was much improved when they were blended with chitin nanofibers or surface-deacetylated chitin nanofibers. Moreover, these composite materials showed good biocompatibility. These findings indicate that the composites prepared in this study are promising materials as new biological adhesives.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (39 results)

All 2015 2014 2013

All Journal Article (26 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 26 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (13 results)

  • [Journal Article] Biological adhesive based on carboxymethyl chitin derivatives and chitin nanofibers2015

    • Author(s)
      Kazuo Azuma, Masahiro Nishihara, Haruki Shimizu, Yoshiki Ito, Osamu Takashima, Tomohiro Osaki, Norihiko Ito, Tomohiro Imagawa, Yusuke Murahata, Takeshi Tsuka, Hironori Izawa, Shinsuke Ifuku, Saburo Minami, Hiroyuki Saimoto, Yoshiharu Okamoto, Minoru Morimoto
    • Journal Title

      Biomaterials

      Volume: 42 Pages: 20-29

    • DOI

      10.1016/j.biomaterials.2014.11.043

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Green Approach to Endow Chitin Nanofiber with Fluorescence2015

    • Author(s)
      Ajoy Kumar Dutta, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      Journal of Chitin and Chitosan Science

      Volume: 3 Issue: 1 Pages: 53-56

    • DOI

      10.1166/jcc.2015.1085

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials2015

    • Author(s)
      Kazuo Azuma, Ryotaro Izumi, Tomohiro Osaki, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki Saimoto, Saburo Minami, Yoshiharu Okamoto
    • Journal Title

      Journal Functional Biomaterials

      Volume: 6 Issue: 1 Pages: 104-142

    • DOI

      10.3390/jfb6010104

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Preparation of zwitterionically charged nanocrystals by surface TEMPO-mediated oxidation and partial deacetylation of alpha-chitin2015

    • Author(s)
      S. Ifuku, T. Hori, H. Izawa, M. Morimoto, H. Saimoto
    • Journal Title

      Carbohydrate Polymers

      Volume: 122 Pages: 1-4

    • DOI

      10.1016/j.carbpol.2014.12.060

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of surface-deacetylated chitin nanofibers in an experimental model of hypercholesterolemia2015

    • Author(s)
      K. Azuma, T. Nagae, T. Nagai, H. Izawa, M. Morimoto, Y. Murahata, T. Osaki, T. Tsuka, T. Imagawa, N. Ito, Y. Okamoto, H. Saimoto, S. Ifuku
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 16 Issue: 8 Pages: 17445-17455

    • DOI

      10.3390/ijms160817445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterizaion of chitosan nanofiber Sheets for Antifungal Application2015

    • Author(s)
      Mayumi Egusa, Ryo Iwamoto, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Hironori Kaminaka, Shinsuke Ifuku
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 16 Pages: 26202-26210

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effect of chitin urocanate nanofibers against ultraviolet radiation2015

    • Author(s)
      Ikuko Ito, Toshikazu Yoneda, Yoshihiko Omura, Tomohiro Osaki*, Shinsuke Ifuku, Hiroyuki Saimoto, Kazuo Azuma, Tomohiro Imagawa, Takeshi Tsuka, Yusuke Murahata, Norihiko Ito, Yoshiharu Okamoto, Saburo Minami
    • Journal Title

      Marine Drugs

      Volume: 13 Issue: 12 Pages: 7463-7475

    • DOI

      10.3390/md13127076

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation of a protein-chitin nanofiber complex from crab shells and its application as a reinforcement filler or substrate for biomineralization2015

    • Author(s)
      S. Ifuku, T. Urakami, H. Izawa, M. Morimoto, H. Saimoto
    • Journal Title

      RSC Advances

      Volume: 5 Issue: 79 Pages: 64196-64201

    • DOI

      10.1039/c5ra12761k

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile preparation of silver nanoparticles immobilized on chitin nanofiber surfaces to endow antifungal activities2015

    • Author(s)
      S. Ifuku, Y. Tsukiyama, T. Yukawa, M. Egusa, H. Kaminaka, H. Izawa, M. Morimoto, H. Saimoto
    • Journal Title

      Carbohydrate Polymers

      Volume: 117 Pages: 813-817

    • DOI

      10.1016/j.carbpol.2014.10.042

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preparation of chitosan nanofibers from completely deacetylated chitosan powder by a downsizing process2015

    • Author(s)
      Yihun Fantahun Akilog, Ajoy Kumar Dutta, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      International Journal Biological Macromolecules

      Volume: 72 Pages: 1191-1195

    • DOI

      10.1016/j.ijbiomac.2014.10.042

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Facile preparation of surface N-halamine chitin nanofiber to endow antibacterial and antifungal activities2015

    • Author(s)
      Ajoy Kumar Dutta, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      Carbohydrate Polymers

      Volume: 115 Pages: 342-347

    • DOI

      10.1016/j.carbpol.2014.08.094

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and functionality of chitin and chitosan derivatives2014

    • Author(s)
      M. Morimoto, H. Izawa, S. Ifuku, H. Saimoto
    • Journal Title

      Chitin and Chitosan Res.

      Volume: 20 Pages: 204-211

    • NAID

      40020252142

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surface maleylation and naphthaloylation of chitin nanofibers for property enhancement2014

    • Author(s)
      S. Ifuku, N. Suzuki, H. Izawa, M. Morimoto, H. Saimoto
    • Journal Title

      Reactive & Functional Polymers

      Volume: 85 Pages: 121-125

    • DOI

      10.1016/j.reactfunctpolym.2014.06.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel preparation of chitin nanocrystals by H2SO4 and H3PO4 hydrolysis followed by high-pressure water jet treatments2014

    • Author(s)
      A. K. Dutta, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku
    • Journal Title

      Journal of Chitin and Chitosan Science

      Volume: 2 Issue: 3 Pages: 179-184

    • DOI

      10.1166/jcc.2014.1067

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Facile preparation of aramid nanofibers from Twaron fibers by a downsizing process2014

    • Author(s)
      S. Ifuku, H. Maeta, H. Izawa, M. Morimoto, H. Saimoto
    • Journal Title

      RSC Advances

      Volume: 4 Issue: 76 Pages: 40377-40380

    • DOI

      10.1039/c4ra06924b

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of chitin nanofibril combined in rayon animal bedding on hairless mouse skin and on a three dimensional culture human skin model2014

    • Author(s)
      I. Ito, T. Osaki, K. Tokuda, T. Asami, Y. Takamori, S. Kurozum, S. Ifuku, H. Saimoto, T. Imagawa, K. Azuma, T. Tsuka, Y. Okamoto, S. Minami
    • Journal Title

      Journal of Chitin and Chitosan Science

      Volume: 2 Issue: 2 Pages: 82-88

    • DOI

      10.1166/jcc.2014.1040

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surface phthaloylation of chitin nanofiber in aqueous media to improve solubility in aromatic solvents and give thermo-responsive and ultraviolet protection protperties2014

    • Author(s)
      S. Ifuku, N. Suzuki, H. Izawa, M. Morimoto, H. Saimoto
    • Journal Title

      RSC Advances

      Volume: 4 Issue: 37 Pages: 19246-19250

    • DOI

      10.1039/c4ra01975j

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Depolymerization of sulfated polysaccharides under hydrothermal conditions2014

    • Author(s)
      Minoru Morimoto, Masaaki Takatori, Tetsuya Hayashi, Daiki Mori, Osamu Takashima, Shinichi Yoshida, Kimihiko Sato, Hitoshi Kawamoto, Jun-ichi Tamura, Hironori Izawa, Shinsuke Ifuku, Hiroyuki Saimoto
    • Journal Title

      Carbohydrate Research

      Volume: 384 Pages: 56-60

    • DOI

      10.1016/j.carres.2013.11.017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the effect of chitin nanofibris on skin functions using skin models2014

    • Author(s)
      Ikuko Ito, Tomohiro Osaki, Shinsuke Ifuku, Hiroyuki Saimoto, Yoshimori Takamori, Seiji Kurozumi, Tomohiro Imagawa, Kazuo Azuma, Takeshi Tsuka, Yoshiharu Okamoto, Saburo Minami
    • Journal Title

      Carbohydrate Polymers

      Volume: 101 Pages: 464-470

    • DOI

      10.1016/j.carbpol.2013.09.074

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Control of mechanical properties of chitin nanofiber film using glycerol without losing its characteristics2014

    • Author(s)
      Shinsuke Ifuku, Akiko Ikuta, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto
    • Journal Title

      Carbohydrate Polymers

      Volume: 101 Pages: 714-717

    • DOI

      10.1016/j.carbpol.2013.09.076

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of cellulose nanofiber made from pear in inflammatory bowel disease model2014

    • Author(s)
      Kazuo Azuma, Tomohiro Osaki, Shinsuke Ifuku, Hiroyuki Saimoto, Osamu Takashima, Takeshi Tsuka, Tomohiro Imagawa, Yoshiharu Okamoto, Saburo Minami
    • Journal Title

      Bioactive Carbohydrates and Dietary Fibre

      Volume: 3 Issue: 1 Pages: 1-10

    • DOI

      10.1016/j.bcdf.2013.11.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fiber width and molecular weight studies of alpha-chitin nanofibers2013

    • Author(s)
      Ajoy Kumar Dutta, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      Jouranl of Chitin and Chitosan Science

      Volume: 1 Issue: 3 Pages: 192-196

    • DOI

      10.1166/jcc.2013.1024

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simple Preparation of Chitin Nanofibers from Dry Squid Pen β-chitin Powder by the Star Burst System2013

    • Author(s)
      Ajoy Kumar Dutta, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      Jouranl of Chitin and Chitosan Science

      Volume: 1 Issue: 3 Pages: 186-191

    • DOI

      10.1166/jcc.2013.1023

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preparation of high-strength and transparent chitosan film reinforced with surface deacetylated chitin nanofibers2013

    • Author(s)
      Ifuku, S., Ikuta, A., Egusa, M., Kaminaka, H., Izawa, H., Morimoto, M., Saimoto, H.
    • Journal Title

      Carbohydrate Polymymers

      Volume: 98 Issue: 1 Pages: 1198-1202

    • DOI

      10.1016/j.carbpol.2013.07.033

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simple preparation of chitosan nanofibers from dry chitosan powder by the Star Burst system2013

    • Author(s)
      Ajoy Kumar Dutta, Naoki Kawamoto, Gaku Sugino, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Journal Title

      Carbohydrate Polymers

      Volume: 97 Issue: 2 Pages: 363-367

    • DOI

      10.1016/j.carbpol.2013.05.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Comparative Study Analysis of alpha-Chitin and beta-Chitin Nanofibrils by Using an Inflammatory-Bowel Disease Mouse Model2013

    • Author(s)
      Kazuo Azuma, Tomohiro Osaki, Shinsuke Ifuku, Hiroyuki Saimoto, Takeshi Tsuka, Tomohiro Imagawa, Yoshiharu Okamoto, and Saburo Minami
    • Journal Title

      Journal of Chitin and Chitosan Science

      Volume: 1 Issue: 2 Pages: 144-149

    • DOI

      10.1166/jcc.2013.1020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 表面脱アセチル化キチンナノファイバーの創傷治癒促進効果2015

    • Author(s)
      泉良太郎, 東和生, 井澤浩則, 森本稔, 斎本博之, 伊福伸介
    • Organizer
      第29回日本キチン・キトサン学会大会
    • Place of Presentation
      東海大学熊本キャンパス
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] N-硫酸化シクロデキストリングラフトキトサンの調製2015

    • Author(s)
      吉橋雅, 伊福伸介, 森本稔, 斎本博之, 井澤浩則
    • Organizer
      第29回日本キチン・キトサン学会大会
    • Place of Presentation
      東海大学熊本キャンパス
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 完全脱アセチル化キトサンからの粉砕によるナノファイバーの調製2015

    • Author(s)
      Yihun F. Akilog, Ajoy K. Dutta, 井澤浩則, 森本稔, 斎本博之, 伊福伸介
    • Organizer
      第29回日本キチン・キトサン学会大会
    • Place of Presentation
      東海大学熊本キャンパス
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 表面脱アセチル化キチンナノファイバーの抗肥満効果2014

    • Author(s)
      東和生、大崎智弘、今川智敬、柄武志、伊藤典彦、村端悠介、井澤浩則、斎本博之、南三郎、岡本芳晴、伊福伸介
    • Organizer
      第28回キチン・キトサンシンポジウム
    • Place of Presentation
      順天堂大学
    • Year and Date
      2014-08-07 – 2014-08-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Fascile N-chlorination of chitin nanofibers for endowing anti-hungal and bacterial properties2014

    • Author(s)
      A. K. Dutta, 江草真由美、井澤浩則、森本 稔、斎本博之、伊福伸介
    • Organizer
      第28回キチン・キトサンシンポジウム
    • Place of Presentation
      順天堂大学
    • Year and Date
      2014-08-07 – 2014-08-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 生物材料由来の新規細胞培養基質2014

    • Author(s)
      小川陽子、斎本博之、井澤浩則、森本 稔、伊藤典彦、伊福伸介
    • Organizer
      第28回キチン・キトサンシンポジウム
    • Place of Presentation
      順天堂大学
    • Year and Date
      2014-08-07 – 2014-08-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of tissue adhesive using carboxymethyl chitin derivatives2013

    • Author(s)
      Yoshiki Ito, Haruki Shimizu, Masahiro Nishihar, Osamu Takashima, Hironori Izawa, Shinsuke Ifuku, Minoru Morimoto, Tomohiro Osaki, Yoshiharu Okamoto, Saburo Minami, Hiroyuki Saimoto
    • Organizer
      10th Asia-Pacific Chitin & Chitosan Symposium
    • Place of Presentation
      Yonago Convention Center, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of biological adhesive agents by using chitin nanofibers2013

    • Author(s)
      Masahiro Nishihara, Tomohiro Osaki, Yoshiki Itoh, Haruki Shimizu, Osamu Takashima, Hironori Izawa, Minoru Morimoto, Shinsuke Ifuku, Hiroyuki Saimoto, Kazuo Azuma, Tomohiro Imagawa, Takeshi Tsuka, Yoshiharu Okamoto, Saburo Minami
    • Organizer
      10th Asia-Pacific Chitin & Chitosan Symposium
    • Place of Presentation
      Yonago Convention Center, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Preparation of high-strength transparent film reinforced with surface-deacetylated chitin nanofibers2013

    • Author(s)
      Shinsuke Ifuku, Akiko Ikuta, Mayumi Egusa, Hironori Kaminaka, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto
    • Organizer
      10th Asia-Pacific Chitin & Chitosan Symposium
    • Place of Presentation
      Yonago Convention Center, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Preparation of chitin and chitosan nanofibers from dry chitin and chitosan powder by using star burst system2013

    • Author(s)
      Ajoy Dutta, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
    • Organizer
      10th Asia-Pacific Chitin & Chitosan Symposium
    • Place of Presentation
      Yonago Convention Center, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Method for replacing water in chitin nanofibers suspension with organic solvent2013

    • Author(s)
      Toshikazu Yoneda, Shinsuke Ifuku, Hiroyuki Saimoto, Yoshihiko Omura
    • Organizer
      10th Asia-Pacific Chitin & Chitosan Symposium
    • Place of Presentation
      Yonago Convention Center, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Preparation of N-phthaloylated chitin nanofibers and its characterization2013

    • Author(s)
      Nana Suzuki, Akihiro Matsui, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki Saimoto
    • Organizer
      10th Asia-Pacific Chitin & Chitosan Symposium
    • Place of Presentation
      Yonago Convention Center, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] A comparative study between α-chitin nanofibrils and β-chitin nanofibrils using an inflammatory bowel disease mouse model2013

    • Author(s)
      Kazuo Azuma, Tomohiro Osaki, Tomohiro Imagawa, Takeshi Tsuka, Shinsuke Ifuku, Hiroyuki Saimoto, Yoshiharu Okamoto, Saburo Minami
    • Organizer
      10th Asia-Pacific Chitin & Chitosan Symposium
    • Place of Presentation
      Yonago Convention Center, Japan
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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