| Project/Area Number |
25430002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kobe Pharmaceutical University (2015-2016)
University of Tsukuba (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KANAHO Yasunori 筑波大学, 医学医療系, 教授 (00214437)
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| Research Collaborator |
SUZUKI Atsushi
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞膜脂質 / 神経突起 / 神経科学 / 生体脂質 / シグナル伝達 / 発生 |
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| Outline of Final Research Achievements |
In this research, we have investigated the functional roles and molecular mechanisms of intramembranous movement of phosphatidylethanolamine (PE) in cellular membrane on axon regeneration of peripheral nerve. In primary cell culture experiments, we revealed that intracellular calcium upregulation is a critical mediator for the intramembranous movement of PE. In addition, we have investigated the expression of tissue inhibitor of metalloproteinase (Timp) family proteins, which are regulators of matrix metalloproteinases and bind to membrane phospholipid. The results indicated that Timp-3 is upregulated in peripheral axon injury, although Timp-1 is specifically upregulated in brain ischemic stroke.
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