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Multisynaptic pathway from retinal ganglion cells to visual areas V4 and MT

Research Project

Project/Area Number 25430004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Tokyo

Principal Investigator

SAWAMURA Hiromasa  東京大学, 医学部附属病院, 助教 (70444081)

Co-Investigator(Renkei-kenkyūsha) NINOMIYA TAIHEI  京都大学霊長類研究所, 統合脳システム分野, 研究員 (40586343)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords狂犬病ウイルス
Outline of Final Research Achievements

Employing retrograde transsynaptic transport of rabies virus, we analyzed the architecture of bottom-up pathways from retinal ganglion cells to ventral stream area V4 (visual area 4) and dorsal stream area MT /V5 (middle temporal area/visual area 5). Labeled cells were observed in reina. It was supposed that the connection from retinal ganglion cells to V4 or MT/V5 might have minimally trisyanptic or disyanptic manner, respectively.
In addition, from the side of pathophysiology, we investigated the case of higher visual dysfunction of dyschromatopsia and lack of stereopsis due to the rare encephalitis and reported the relationship between retina and higher visual areas. The retina and macular were not damaged even if cortical visual areas were functionally damaged.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Anti-NMDA receptor encephalitis associated with transient cerebral dyschromatopsia, prosopagnosia, and lack of stereopsis2014

    • Author(s)
      Sawamura H, Yamamoto T, Ohtomo R, Bannai T, Wakakura M, and Tsuji S
    • Journal Title

      J. Neuro-Ophthalmol.

      Volume: 34 Issue: 2 Pages: 144

    • DOI

      10.1097/wno.0000000000000117

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrent optic neuropathy caused by a mucocele of the anterior clinoid process after a 5-year remission: A case report and literature review2014

    • Author(s)
      Aoyama Y, Ohtomo K, and Sawamura H *
    • Journal Title

      Neuro-Ophthalmology

      Volume: 38 Issue: 5 Pages: 281

    • DOI

      10.3109/01658107.2014.938274

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Temporal changes in a giant macular hole formed secondary to toxoplasmic retinochoroiditis2014

    • Author(s)
      Tanaka R, Obata R, Sawamura H, Ohtomo K, Kaburaki T
    • Journal Title

      Can J Ophthalmol

      Volume: 49 Issue: 5 Pages: e115-e118

    • DOI

      10.1016/j.jcjo.2014.06.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Juvenile onset of ocular hypertension associated with de novo nail-patellar syndrome2014

    • Author(s)
      Sawamura H, Aihara M, Araie M.
    • Journal Title

      J Glaucoma

      Volume: 23 Issue: 2 Pages: e122-e125

    • DOI

      10.1097/ijg.0b013e3182953b08

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大脳生理における最近の知見2013

    • Author(s)
      澤村裕正
    • Journal Title

      神経眼科

      Volume: 30 Pages: 399-405

    • Related Report
      2013 Research-status Report
  • [Presentation] 末期緑内障に巨細胞性動脈炎から生じた​後部虚血性視神経症を呈した一例2015

    • Author(s)
      澤村裕正
    • Organizer
      第53回日本神経眼科学会
    • Place of Presentation
      大宮
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高次視覚野における多シナプス性ニューロンネットワーク2015

    • Author(s)
      澤村裕正
    • Organizer
      第24回海馬と高次脳機能学会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 視神経炎の病型と臨床像の検討2015

    • Author(s)
      白濱 新多朗、 蕪城 俊克、 澤村 裕正 他 4名
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 5年間の緩寛を経て再発した、前床状突起粘液嚢胞による視神経症の一例2014

    • Author(s)
      青山裕加、大友一義、澤村裕正
    • Organizer
      第52回日本神経眼科学会
    • Place of Presentation
      千葉
    • Year and Date
      2014-12-12 – 2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 内頸動脈海綿静脈洞部の動脈瘤に対しコイル塞栓術施行後に外転神経麻痺の悪化をきたした一例2014

    • Author(s)
      乾 博子、澤村 裕正、若倉 雅登、保手濱 充啓、花川 一郎
    • Organizer
      第52回日本神経眼科学会
    • Place of Presentation
      千葉
    • Year and Date
      2014-12-12 – 2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 小児斜視患者における視差以外の手掛かりを用いた飛び出し知覚2014

    • Author(s)
      澤村 裕正, C. Gillebert, J.T. Todd, R. Vandenberghe, G.A. Orban
    • Organizer
      第70回日本弱視斜視学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 3D shape perception in strabismus subjects.2014

    • Author(s)
      H. Sawamura, C.R. Gillebert, J.T. Todd, R. Vandenberghe, G.A. Orban
    • Organizer
      EUROPEAN ASSOCIATION FOR VISION AND EYE RESEARCH
    • Place of Presentation
      Nice, France
    • Year and Date
      2014-10-01 – 2014-10-04
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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