| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
1. We newly generated an adenoviral vector expressing antisense RNA of Wnt7b. The adenoviral vector suppressed successfully Wnt7b-expression in vitro and in vivo. Using the adenoviral vector, we suppressed Wnt7b-expression in neurons born on embryonic day (E)11.5, selectively. Wnt7b-suppression caused underdevelopment, neocortex hypoplasia, cerebellar vermis hypoplasia, autism-like abnormal behavior, and abnormal EEG.
2. We newly made two kinds of optical-stimulators that were small enough to mount the device on a mouse head.One was controlled by infrared wireless communication and another one was controlled bywireless communication of Bluetooth 4.0 (Bluetooth Low Energy) . The Bluetooth-device could be modulated by an iPad or iPhone application.
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