Kinetics of synaptic vesicle filling with neurotransmitter GABA
| Project/Area Number |
25430016
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | Doshisha University |
|---|
Principal Investigator |
Hori Tetsuya 同志社大学, 生命医科学部, 准教授 (70396703)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | シナプス小胞 / 前シナプス / GABA / 抑制性シナプス / 小脳 / マウス |
|---|
| Outline of Final Research Achievements |
After releasing neurotransmitter, synaptic vesicles are retrieved by endocytosis and recycled vir fast and slow pathways to be reused for synaptic transmission. To maintai the synaptic efficacy, vesicles must be refilled with neurotransmitter during recycling. We examined the vesicle refilling rate directry at central GABAergic synapses, using caged GABA photolysis. The refilling of vesicles with GABA was about 1 min.
|
Report
(4 results)
Research Products
(1 results)
