Opposing functions of chondroitin sulfate and heparan sulfate in the neural network formation
| Project/Area Number |
25430081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
MAEDA Nobuaki 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, プロジェクトリーダー (90202308)
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| Co-Investigator(Kenkyū-buntansha) |
神村 圭亮 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 (30529524)
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| Research Collaborator |
MARUYAMA Chiaki (OHTAKA Chiaki)
SAEGUSA Chika
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | コンドロイチン硫酸 / ヘパラン硫酸 / プロテオグリカン / 神経筋接合部 / 神経細胞移動 / ショウジョウバエ / 神経回路形成 / グリピカン / シンデカン / シナプス / 神経回路 / 子宮内胎仔電気穿孔法 |
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| Outline of Final Research Achievements |
We analyzed the functions of proteoglycans in the nervous system using two model organisms: Drosophila melanogaster and mouse. We revealed that syndecan (Sdc) and glypican (Dlp) play opposing roles in the neurotransmission at Drosophila neuromuscular junction and in the locomotion of larvae. We also found that Dlp regulates synaptic plasticity at the neuromuscular junction. Furthermore, we found that chondroitin sulfate proteoglycans play critical roles in the neuronal migration and polarization of excitatory neurons in the developing mouse neocortex
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Structural and biochemical characterization of O-mannose-linked HNK-1 glycan expressed on phosphacan in developing mouse brains.2014
Author(s)
Morise J, Kizuka Y, Yabuno K, Tonoyama Y, Hashii N, Kawasaki N, Manya H, Miyagoe-Suzuki Y, Takeda S, Endo T, Maeda N, Takematsu H, and Oka S.
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Journal Title
Glycobiology
Volume: 24
Issue: 3
Pages: 314-324
DOI
Related Report
Peer Reviewed / Open Access
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