Development of novel tumor markers for renal cell carcinoma by evaluating small nuclear acid in blood
Project/Area Number |
25430137
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor diagnostics
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Research Institution | Kagoshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOJIMA SATOKO 帝京大学, 医学部, 准教授 (10345019)
SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
ENOKIDA HIDEKI 鹿児島大学, 医歯学域医学系, 准教授 (80347103)
NAKAGAWA MASAYUKI 鹿児島大学, 医歯学域医学系, 教授 (90164144)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
Keywords | マイクロRNA / 腎細胞癌 / 腫瘍マーカー / microRNA |
Outline of Final Research Achievements |
We focused on miR-200s (miR-200a/miR-200b/miR-429 cluster and miR-200c/miR-141cluster). ZEB1/2 genes that are key molecules for EMT were repressed by miR-200s transfection. miR-138 targeted Vimentin which was under stream of ZEB1/2. Tumor suppressive miR-29s repressed LOXL2 and lead to instability of ECM. These microRNAs could be a biomarker of renal cell carcinoma.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Expression of the tumor suppressive miRNA-23b/27b cluster is a good prognostic marker in clear cell renal cell carcinoma.2014
Author(s)
Ishihara T, Seki N, Inoguchi S, Yoshino H, Tatarano S, Yamada Y, Itesako T, Goto Y, Nishikawa R, Nakagawa M, Enokida H.
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Journal Title
The Journal of Urology
Volume: 192
Issue: 6
Pages: 1822-1830
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] MicroRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway.2013
Author(s)
Yamasaki T, Seki N, Yoshino H, Itesako T, Hidaka H, Yamada Y, Tatarano S, Yonezawa T, Kinoshita T, Nakagawa M, Enokida H.
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Journal Title
Journal of Urology
Volume: 190
Pages: 1059-2068
Related Report
Peer Reviewed
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