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Augmentation of tumor immune response by depletion of regulatory T cells

Research Project

Project/Area Number 25430161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor therapeutics
Research InstitutionKawasaki University of Medical Welfare

Principal Investigator

NAKAYAMA EIICHI  川崎医療福祉大学, 医療福祉学部, 教授 (60180428)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsがん免疫 / 腫瘍内浸潤リンパ球 / 制御性T細胞 / ケモカイン受容体CCR4 / ケモカインCCL22/MDC / 抗体依存性細胞障害性(ADCC) / ヒト化抗CCR4単クローン抗体 / 制御性T細胞除去 / ADCC活性 / 遊走 / 肺癌 / 肺がん / ケモカイン受容体
Outline of Final Research Achievements

Augmentation of tumor immune response by depletion of regulatory T cells (Tregs) was pursued by the following studies. 1. On three Treg subpopulations, resting Tregs, activated Tregs and nonTregs, difference of the expression of CCR4 chemokine receptor on their surface and of their distribution in PBMC and TIL was demonstrated. 2. The presence of CCR4-expressing Tregs and CCL22/MDC in the local tumor site was shown by immunohistochemistry. 3. CD25 CD4 Tregs with migratory activity were shown to be eliminated by CCR4(KM2760)mAb with antibody-dependent cell-mediated cytotoxicity(ADCC). 4. Efficient depletion of Tregs by injection of humanized anti-CCR4( KW-0761)mAb in solid cancer patients was demonstrated.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (73 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (25 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 19 results,  Open Access: 8 results,  Acknowledgement Compliant: 5 results) Presentation (47 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Immune Responses to the Cancer Testis Antigen XAGE-1b in Non Small Cell Lung Cancer Caucasian Patients.2016

    • Author(s)
      Saito K, Nakayama E, Valmori D.
    • Journal Title

      PLOS ONE

      Volume: 11(3) Issue: 3 Pages: e0150623-e0150623

    • DOI

      10.1371/journal.pone.0150623

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] モガムリズマブの新しい展開2016

    • Author(s)
      鈴木 進、中山睿一、黒瀬浩史、上田龍三
    • Journal Title

      最新医学

      Volume: 71(1) Pages: 126-133

    • NAID

      40020708354

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 2015 Guidance on cancer immunotherapy development in early-phase clinical studies.2015

    • Author(s)
      Kageyama S, et al. (他 50名)
    • Journal Title

      Cancer Sci.

      Volume: 106(12) Pages: 1761-1771

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensitive multiplexed quantitative analysis of autoantibodies to cancer antigens with chemically S-cationized full-length and water-soluble denatured proteins.2015

    • Author(s)
      Futami J, Nonomura H, Kido M, Niidoi N, Fujieda N, Hosoi A, Fujita K, Mandai K, Atago Y, Kinoshita R, Honjo T, Matsushita H, Uenaka A, Nakayama E, and Kakimi K.
    • Journal Title

      Bioconjugate Chem.

      Volume: 26(10) Issue: 10 Pages: 2076-2084

    • DOI

      10.1021/acs.bioconjchem.5b00328

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrasting effects of the cytotoxic anticancer drug Gemcitabine and the EGFR tyrosine kinase inhibitor Gefitinib on NK cell-mediated cytotoxicity via regulation of NKG2D ligand in non-small-cell lung cancer cells.2015

    • Author(s)
      Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, Shimizu K, Yamaguchi Y, Oka M, Nakayama E, Lundqvist A, Kiessling R, Seliger B, Nakata M.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: e0139809-e0139809

    • DOI

      10.1371/journal.pone.0139809

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients.2015

    • Author(s)
      2.Kurose K, Ohue Y, Wada H, Iida S, Ishida T, Kojima T, Doi T, Suzuki S, Isobe M, Funakoshi T, Kakimi K, Nishikawa H, Udono H, Oka M, Ueda R, Nakayama E.
    • Journal Title

      Clin Cancer Res.

      Volume: 21 Issue: 19 Pages: 4327-36

    • DOI

      10.1158/1078-0432.ccr-15-0357

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient.2015

    • Author(s)
      Miyai M, Eikawa S, Hosoi A, Iino T, Matsushita H, Isobe M, Uenaka A, Udono H, Nakajima J, Nakayama E, Kakimi K.
    • Journal Title

      PLoS One

      Volume: 10(8) Issue: 8 Pages: e0136086-e0136086

    • DOI

      10.1371/journal.pone.0136086

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] がん抗原(第7章)The Frontiers in Life Sciences「がんと免疫」2015

    • Author(s)
      中山睿一
    • Journal Title

      がん免疫療法のメカニズム解明と臨床への展開

      Volume: 1 Pages: 51-59

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Immune-mediated anti-tumor effect by type 2 diabetes drug, metformin.2015

    • Author(s)
      Eikawa S, Nishida M, Mizukami S, Yamazaki C, Nakayama E and Udono H.
    • Journal Title

      Pros Natl Acd Sci USA

      Volume: 112 (6) Issue: 6 Pages: 1809-1814

    • DOI

      10.1073/pnas.1417636112

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increase of activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an anti-human CCR4 mAb (KM2760).2015

    • Author(s)
      Koji Kurose, Yoshihiro Ohue, Eiichi Sato Akira Yamauchi, Shingo Eikawa, Midori Isobe, Yumi Nishio, Akiko Uenaka, Mikio Oka, and Eiichi Nakayama.
    • Journal Title

      J Thorac Oncol.

      Volume: 10 Issue: 1 Pages: 74-83

    • DOI

      10.1097/jto.0000000000000364

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 基礎:抗CCR4抗体の制御性T細胞への影響と臨床応用の可能性2015

    • Author(s)
      黒瀬浩史、岡 三喜男、中山睿一
    • Journal Title

      最新医学

      Volume: 70 (3) Pages: 393-398

    • Related Report
      2014 Research-status Report
  • [Journal Article] がん精巣抗原に対する免疫応答とその臨床的意義2015

    • Author(s)
      岡 三喜男、大植祥弘、黒瀬浩史、中山睿一
    • Journal Title

      BIO Clinica

      Volume: 30 (3) Pages: 31-35

    • Related Report
      2014 Research-status Report
  • [Journal Article] Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody.2014

    • Author(s)
      Ohue Y, Kurose K, Mizote Y, Matsumoto H, Nishio Y, Isobe M, Fukuda M, Uenaka A, Oka M and Nakayama E.
    • Journal Title

      Clin. Cancer Res.

      Volume: 20 (19) Issue: 19 Pages: 5052-5063

    • DOI

      10.1158/1078-0432.ccr-14-0742

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antibody response to cancer/testis (CT) antigens: A prognostic marker in cancer patients.2014

    • Author(s)
      Ohue Y, Wada H, Oka M and Nakayama E.
    • Journal Title

      OncoImmunology

      Volume: 3 Pages: 11-11

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genetic variants of immunoglobulin γ and κ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer.2014

    • Author(s)
      Pandey JP, Namboodiri AM, Ohue Y, Oka M, Nakayama E.
    • Journal Title

      Clinical Experimental Immunology

      Volume: 176 Issue: 1 Pages: 78-83

    • DOI

      10.1111/cei.12247

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vaccination With NY-ESO-1 Overlapping Peptides Mixed With Picibanil OK-432 and Montanide ISA-51 in Patients With Cancers Expressing the NY-ESO-1 Antigen2014

    • Author(s)
      Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Yamasaki M, Miyata H, Matsushita H, Udono H, Seto Y, Yamada K, Nishikawa H, Pan L, Venhaus R, Oka M, Doki Y, Nakayama E.
    • Journal Title

      J Immunother

      Volume: 37(2) Issue: 2 Pages: 84-92

    • DOI

      10.1097/cji.0000000000000017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of NY-ESO-1 peptide/DRB1*08:03 tetramers and ex vivo detection of CD4 T-cell responses in vaccinated cancer patients.2014

    • Author(s)
      Mizote Y, Uenaka A, Isobe M, Wada H, Kakimi K, Saika T, Kita S, Koide Y, Oka M, Nakayama E.
    • Journal Title

      Vaccine.

      Volume: Epub 2014 Jan 5. Issue: 8 Pages: 957-964

    • DOI

      10.1016/j.vaccine.2013.12.042

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD).2014

    • Author(s)
      Mizote, Y., Wakamatsu, K., Ito, S., Uenaka, A., Ohue, Y., Kurose, K., Isobe, M., Ito, A., Tamura, Y., Honda, H., Yamashita, T., Nohara, S., Oka, M., Jimbow, K., Nakayama, E.
    • Journal Title

      J. Dermatol. Sci.

      Volume: 73 Issue: 3 Pages: 76-87

    • DOI

      10.1016/j.jdermsci.2013.11.006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Melanoma-targeted chemo-thermotherapy and in situ peptide immunotherapy through HSP production by using melanogenesis substrate, NPrCAP and magnetite nanoparticles.2013

    • Author(s)
      Jimbow, K.
    • Journal Title

      J. Skin Cancer

      Volume: 2013 Pages: 174-180

    • DOI

      10.1155/2013/742925

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8+ T cells2013

    • Author(s)
      Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
    • Journal Title

      Vaccine

      Volume: 31(17) Issue: 17 Pages: 2110-2118

    • DOI

      10.1016/j.vaccine.2013.02.056

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein.2013

    • Author(s)
      Reis BS, Jungbluth AA, Frosina D, Holz M, Ritter E, Nakayama E, Ishida T, Obata Y, Carver B, Scher H, Scardino P, Slovin S, Subudhi SK, Reuter VE, Savage C, Allison JP, Melamed JM, Jager E, Ritter G, Old LJ, Gnjatic S.
    • Journal Title

      Clin. Cancer Res.

      Volume: 19(22) Issue: 22 Pages: 6112-6125

    • DOI

      10.1158/1078-0432.ccr-12-3580

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013

    • Author(s)
      Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K
    • Journal Title

      J Gastroenterol

      Volume: 48(12) Issue: 12 Pages: 1373-1383

    • DOI

      10.1007/s00535-013-0763-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] がん患者における免疫モニタリング―評価法と国際標準化2013

    • Author(s)
      和田 尚、中山睿一
    • Journal Title

      週刊 医学のあゆみ がんの免疫制御―研究と臨床の最前線

      Volume: 244(9) Pages: 871-877

    • Related Report
      2013 Research-status Report
  • [Journal Article] 免疫バイオマーカーと抗腫瘍効果2013

    • Author(s)
      和田 尚、中山睿一
    • Journal Title

      実験医学 増刊 腫瘍免疫学とがん免疫療法

      Volume: 31(12) Pages: 204-208

    • Related Report
      2013 Research-status Report
  • [Journal Article] T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles2012

    • Author(s)
      Ito A, Yamaguchi M, Okamoto N, Sanematsu Y,Kawabe Y, Wakamatsu K, Ito S, Honda H, Kobayashi T, Nakayama E, Tamura Y, Okura M, Yamashita T, Jimbow K, Kamihara M
    • Journal Title

      Nanomedicine

      Volume: (epub ahead of print) Issue: 6 Pages: 891-902

    • DOI

      10.2217/nnm.12.142

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Phase Ⅰa study of FoxP3+ CD4 Treg depletion by infusion of anti-CCR4 antibody in cancer patients2015

    • Author(s)
      黒瀬浩史, 大植祥弘, 西尾祐美, 磯辺みどり, 上中明子, 中山睿一, 岡三喜男
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腫瘍PD-L1, Gal-9, XAGE1発現及びT細胞浸潤を指標とした肺腺癌の予後予測2015

    • Author(s)
      大植祥弘, 黒瀬浩史, 西尾祐美, 磯辺みどり, 上中明子, 中山睿一, 岡三喜男
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Phase I a study of FoxP3+ CD4 Treg depletion by infusion of a humanized anti-CCR4 antibody, KW-0761, in cancer patients2015

    • Author(s)
      黒瀬浩史, 大植祥弘, 和田尚, 飯田真介, 石田高司, 鈴木進, 垣見和宏, 西川博嘉, 上田龍三, 岡三喜男, 中山睿一
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Augmentation of anti-tumor immune responses by N-propionyl cysteaminylphenol-maleimid-dextran (NPCMD)2015

    • Author(s)
      西尾祐美, 溝手雄, 上中明子, 黒瀬浩史, 大植祥弘, 野原聡, 岡三喜男, 中山睿一
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Survival prediciting discriminant function with immune parameters for lung adenocarcinoma patients2015

    • Author(s)
      大植祥弘, 黒瀬浩史, 西尾祐美, 磯辺みどり, 上中明子, 岡三喜男, 中山睿一
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Immunotherapy for solid tumors based on regulation of regulatory T lymphocyte2015

    • Author(s)
      鈴木進, 石田高司, 黒瀬浩史, 大植祥弘, 西川博嘉, 飯田真介, 和田尚, 岡三喜男, 中山睿一, 上田龍三
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Inaugural International Cancer Immunotherapy Conference、New York2015

    • Author(s)
      Ohue Y, Kurose K, Oka M, Nakayama E
    • Organizer
      The Inaugural International Cancer Immunotherapy Conference
    • Place of Presentation
      Sheraton New York Times Square Hotel (New York, USA)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Augmentation of anti-tumor immune responses by N-propionyl cysteaminylphenol-maleimid-dextran (NPCMD)2015

    • Author(s)
      Yumi Nishio, Yu Mizote, Akiko Uenaka, Koji Kurose, Yoshihiro Ohue, Satoshi Nohara, Mikio Oka, Kowichi Jimbow, Eiichi Nakayama
    • Organizer
      第19回日本がん免疫学会総会
    • Place of Presentation
      伊藤国際学術研究センター 伊藤謝恩ホール(東京)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非小細胞肺がん患者で、免疫グロブリンの遺伝的変異がXAGE1免疫に及ぼす影響2015

    • Author(s)
      堅田洋佑, 大植祥弘, 黒瀬浩史, 福田実, 上中明子, JP Pandey, 中山睿一, 岡三喜男
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺癌の腫瘍浸潤リンパ球(TIL)における活性化・抑制性分子の解析2015

    • Author(s)
      黒瀬浩史, 大植祥弘, 西尾祐美, 磯辺みどり, 上中明子, 中山睿一, 岡三喜男
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinical effect of XAGE1 (GAGED2a) antigen expression and antibody response in EGFR mutated and wild-type advanced lung adenocarcinoma2015

    • Author(s)
      Yoshihiro Ohue, Koji Kurose, Yu Mizote, Hirofumi Matsumoto, Yumi Nishio, Midori Isobe, Minoru Fukuda, Akiko Uenaka, Eiichi Nakayama, Mikio Oka
    • Organizer
      55th Annual Meeting of The Japanese Respiratory Society
    • Place of Presentation
      Tokyo Internatuinal Forum (Tokyo)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺腺癌でXAGE1に対する宿主免疫応答の解析と予後延長効果の証明2015

    • Author(s)
      大植祥弘, 黒瀬浩史, 磯辺みどり, 上中明子, 福田実, 中山睿一, 岡三喜男
    • Organizer
      第112回日本内科学会講演会
    • Place of Presentation
      みやこめっせ(京都)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 進行期肺腺癌におけるXAGE1(GAGED2a)免疫と予後2015

    • Author(s)
      大植祥弘, 黒瀬浩史, 岡 三喜男, 中山睿一
    • Organizer
      第12回日本免疫治療学研究会学術集会
    • Place of Presentation
      東京ガーデンパレス(東京都文京区)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Clinical effect of XAGE1(GAGED2a) immunity in advanced lung adenocarcinoma.2015

    • Author(s)
      大植祥弘, 黒瀬浩史, 岡 三喜男, 中山睿一
    • Organizer
      第12回日本免疫治療学研究会学術集会
    • Place of Presentation
      東京ガーデンパレス(東京都文京区)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 非小細胞肺がん患者で、免疫グロブリンγ鎖およびκ鎖の遺伝的変異がXAGE1免疫に及ぼす影響2014

    • Author(s)
      大植祥弘, Janardan Pandey, Aryan Namboodiri, 中山睿一, 岡 三喜男
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 非小細胞肺癌におけるXAGE1免疫の予後延長効果2014

    • Author(s)
      大植祥弘, 黒瀬浩史, 溝手 雄, 松本博文, 西尾祐美, 磯辺みどり, 上中明子, 福田 実, 中山睿一, 岡 三喜男
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Increase of activated Tregs in TIL in lung cancer and depletion of Tregs using anti-human CCR4 mAb.2014

    • Author(s)
      黒瀬浩史, 大植祥弘, 西尾祐美, 磯辺みどり, 堅田洋佑, 阿部公亮, 上中明子, 中山睿一, 岡 三喜男
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical effect of XAGE1 (GAGED2a) antigen expression and antibody response in EGFR mutated and wild-type advanced lung adenocarcinoma.2014

    • Author(s)
      Yoshihiro Ohue, Koji Kurose, Yu Mizote, Hirofumi Matsumoto, Yumi Nishio, Midori Isobe, Minoru Fukuda, Akiko Uenaka, Mikio Oka, and Eiichi Nakayama.
    • Organizer
      22nd Annual International Cancer Immunotherapy Symposium
    • Place of Presentation
      New York (USA)
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Increase of activated Tregs in TIL in lung cancer and in vitro depletion of Tregs by ADCC using anti-human CCR4 mAb (KM2760).2014

    • Author(s)
      Koji Kurose, Yoshihiro Ohue, Shingo Eikawa, Yumi Nishio, Midori Isobe, Akiko Uenaka, Mikio Oka, and Eiichi Nakayama.
    • Organizer
      22nd Annual International Cancer Immunotherapy Symposium
    • Place of Presentation
      New York (USA)
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Increase of activated Tregs in TIL in Lung cancer and in vitro depletion of Tregs by ADCC using anti-human CCR4 mAb2014

    • Author(s)
      Koji Kurose, Yoshihiro Ohue, Shingo Eikawa, Yumi Nishio, Midori Isobe, Akiko Uenaka, Mikio Oka, Eiichi Nakayama
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical effect of XAGE1 immune response in EGFR mutated and wild-type advanced lung adenocarcinoma2014

    • Author(s)
      Yoshihiro Ohue, Koji Kurose, Hirofumi Matsumoto, Yu Mizote, Yumi Nishio, Midori Isobe, Minoru Fukuda, Akiko Uenaka, Mikio Oka, Eiichi Nakayama
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Targeted immunotherapy strategy for non-small cell lung cancer2014

    • Author(s)
      Mikio Oka, Koji Kurose, Yoshihiro Ohue, Eiichi Nakayama
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Monitoring multifunctionality of exhausted CD8 T-cells in cancer patients2014

    • Author(s)
      Mami Negawa, Shingo Eikawa, Takenori Uehara, Yuki Kunisada, Yoshihiro Ohue, Koji Kurose, Midori Isobe, Akiko Uenaka, Eiichi Nakayama, Heiichiro Udono
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Increase of activated Tregs in TIL in lung cancer and in vitro depletion of Tregs by ADCC using anti-human CCR4 mAb (KM2760)2014

    • Author(s)
      黒瀬浩史、大植祥弘、榮川伸吾、西尾祐美、磯辺みどり、上中明子、岡 三喜男、中山睿一
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 制御性T細胞解析方法の標準化に向けた多施設共同研究2014

    • Author(s)
      長瀬博次、和田 尚、西川博嘉、鈴木 進、平家勇司、小嶋隆嗣、垣見和宏、舩越 健、飯田真介、石田高司、佐藤永一、鵜殿平一郎、岡 三喜男、中山睿一、土岐祐一郎、上田龍三
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical effect of XAGE-1 (GAGED2a) antigen expression and antibody response in EGFR mutated and wild-type advanced lung adenocarcinoma.2014

    • Author(s)
      Yoshihiro Ohue, Koji Kurose, Yu Mizote, Hirofumi Matsumoto, Yumi Nishio, Midori Isobe, Minoru Fukuda, Akiko Uenaka, Mikio Oka, Eiichi Nakayama
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] TCRディープシーケンスによるNY-ESO-1特異的T細胞のモニタリング2014

    • Author(s)
      垣見和宏、榮川伸吾、磯辺みどり、松下博和、宮井まなみ、細井亮宏、藤枝奈緒、鵜殿平一郎、上中明子、中山睿一
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Prolonged overall survival in XAGE-1b (GAGED2a) antibody positive NSCLC patients.2014

    • Author(s)
      大植祥弘、黒瀬浩史、溝手 雄、松本博文、磯辺みどり、上中明子、福田 実、中山睿一、岡 三喜男
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.2014

    • Author(s)
      黒瀬浩史、大植祥弘、西尾祐美、磯辺みどり、上中明子、岡 三喜男、中山睿一
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.2013

    • Author(s)
      Kurose K, Eikawa S, Mizote Y, Ohue Y, Isobe M, Uenaka A, Oka M, Nakayama E.
    • Organizer
      104nd Annual Meeting of American Association of Cancer Research (AACR)
    • Place of Presentation
      Walter E. Washington Convention Center (801 Mt. Vernon Place NW, Washington, DC, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Immune response to XAGE-1b (GAGED2a) in NSCLC patients and its clinical relevance.2013

    • Author(s)
      Ohue Y, Kurose K, Eikawa S, Mizote Y, Matsumoto H, Isobe M, Uenaka A, Fukuda M, Nakayama E, Oka M.
    • Organizer
      104nd Annual Meeting of American Association of Cancer Research (AACR)
    • Place of Presentation
      Walter E. Washington Convention Center (801 Mt. Vernon Place NW, Washington, DC, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 非小細胞肺癌患者における癌精巣抗原XAGE-1dに対する免疫応答2013

    • Author(s)
      黒瀬浩史、松本博文、大植祥弘、阿部公亮、榮川伸吾、溝手 雄、磯辺みどり、上中明子、永安 武、中山睿一、岡 三喜男
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区丸の内3丁目5)
    • Related Report
      2013 Research-status Report
  • [Presentation] がん精巣抗原XAGE-1bを標的にしたがん免疫療法の開発2013

    • Author(s)
      大植祥弘、橘髙 誠、黒瀬浩史、池田征樹、阿部公亮、清水大樹、毛利圭二、加藤茂樹、尾長谷靖、小橋吉博、福田 実、中山睿一、岡 三喜男
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区丸の内3丁目5)
    • Related Report
      2013 Research-status Report
  • [Presentation] A phase I study of vaccination with 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.2013

    • Author(s)
      Isobe M, Eikawa S, Kakimi K, Wada H, Mizote Y, Ohue Y, Kurose K, Uenaka A, Oka M, Nakayama E.
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部(山口県宇部市相生町8-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.2013

    • Author(s)
      Kurose K, Eikawa S, Mizote Y, Ohue Y, Isobe M, Uenaka A, Oka M, Nakayama E.
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部(山口県宇部市相生町8-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] Immune response to XAGE-1b (GAGED2a) in NSCLC patients and its clinical relevance.2013

    • Author(s)
      Ohue Y, Kurose K, Mizote Y, Matsumoto Y, Isobe M, Uenaka A, Fukuda M, Oka M, Nakayama E.
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部(山口県宇部市相生町8-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規製剤N-propionyl cysteaminylphenol-maleimid-dextran(NPCMD)による免疫応答賦活効果2013

    • Author(s)
      溝手 雄、若松一雅、伊藤祥輔、上中明子、黒瀬浩史、大植祥弘、西尾祐美、岡 三喜男、神保孝一、中山睿一
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部(山口県宇部市相生町8-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.2013

    • Author(s)
      Kurose K, Ohue Y, Mizote Y, Isobe M, Uenaka A, Oka M, Nakayama E.
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市青葉区青葉山無番地)
    • Related Report
      2013 Research-status Report
  • [Presentation] Immune response to XAGE-1b (GAGED2a) in NSCLC patients and its clinical relevance.2013

    • Author(s)
      Ohue Y, Kurose K, Mizote Y, Matsumoto Y, Isobe M, Fukuda M, Uenaka A, Nakayama E, Oka M.
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市青葉区青葉山無番地)
    • Related Report
      2013 Research-status Report
  • [Presentation] Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.2013

    • Author(s)
      Kurose K, Ohue Y, Mizote Y, Isobe M, Uenaka A, Oka M, Nakayama E.
    • Organizer
      21st Annual Cancer Research Institute International Cancer Immunotherapy Symposium
    • Place of Presentation
      Grand Hyatt Hotel New York (109 East 42nd Street New York, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Prolonged overall survival in XAGE-1b(GAGED2a) antibody positive NSCLC patients.2013

    • Author(s)
      Ohue Y, Kurose K, Mizote Y, Matsumoto H, Isobe M, Uenaka A, Fukuda M, Oka M, Nakayama E.
    • Organizer
      21st Annual Cancer Research Institute International Cancer Immunotherapy Symposium
    • Place of Presentation
      Grand Hyatt Hotel New York (109 East 42nd Street New York, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] NY-ESO-1重複長ペプチドを用いたがんワクチン第I相臨床試験2013

    • Author(s)
      西塔拓郎、和田 尚、磯辺みどり、垣見和宏、榮川伸吾、大植祥弘、西川博嘉、岡 三喜男、森 正樹、土岐祐一郎、中山睿一
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市西区みなとみらい1-1-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] NY-ESO-1(NY-ESO-1 91-110)ペプチドワクチンによる抗体CD4・CD8 T細胞免疫応答の誘導2013

    • Author(s)
      榮川伸吾、垣見和宏、磯辺みどり、和田 尚、上中明子、葛島清隆、西川博嘉、鵜殿平一郎、岡 三喜男、中山睿一
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市西区みなとみらい1-1-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規製剤NPCMDによるTLR4、NLRP3の活性化とT細胞免疫応答の賦活化2013

    • Author(s)
      溝手 雄、若松一雅、伊藤祥輔、上中明子、黒瀬浩史、大植祥弘、西尾祐美、岡 三喜男、神保孝一、中山睿一
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市西区みなとみらい1-1-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] ホジキンリンパ腫におけるNY-ESO-1 に対する液性および細胞性免疫応答2013

    • Author(s)
      鈴木 進、石田高司、森 芙美子、伊藤 旭、楠本 茂、小松弘和、吉川和宏、中山睿一、飯田真介、新実彰男、上田龍三
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市西区みなとみらい1-1-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.2013

    • Author(s)
      黒瀬浩史、大植祥弘、堅田洋佑、阿部公亮、磯辺みどり、松本博文、上中明子、中山睿一、岡 三喜男
    • Organizer
      第54回日本肺癌学会総会
    • Place of Presentation
      ホテルニューオータニ東京(東京都千代田区紀尾井町4-1)
    • Related Report
      2013 Research-status Report
  • [Presentation] Immune response to XAGE-1b (GAGED2a) in NSCLC patients and its clinical relevance.2013

    • Author(s)
      大植祥弘、黒瀬浩史、松本博文、阿部公亮、堅田洋佑、磯辺みどり、上中明子、福田 実、中山睿一、岡 三喜男
    • Organizer
      第54回日本肺癌学会総会
    • Place of Presentation
      ホテルニューオータニ東京(東京都千代田区紀尾井町4-1)
    • Related Report
      2013 Research-status Report
  • [Remarks] 免疫研究室

    • URL

      http://www.med-gakkai.org/kmsrd/igakukyoiku.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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